anti-Human IL-4 antibody for Biochemical Assay

Recommended IL-4 Antibody (supplied by: Log in to see )

Antigen
Interleukin 4 (IL4) Antibodies
  • IL4
  • IL-4
  • BCGF-1
  • BCGF1
  • BSF-1
  • BSF1
  • Il-4
  • Il4e12
  • IL2
  • interleukin 4
  • IL4
  • Il4
  • Il-4
Reactivity
Human
392
208
50
34
24
20
19
14
11
11
9
9
6
6
6
6
5
2
2
1
1
Host
Mouse
266
217
204
7
6
4
Clonality
Monoclonal
Conjugate
This IL-4 antibody is un-conjugated
85
52
32
22
21
12
12
8
8
8
8
8
6
6
6
6
6
4
4
4
4
4
3
2
2
2
2
1
1
Application
Biochemical Assay (BCA)
387
374
255
126
56
46
43
39
39
23
22
22
15
10
9
8
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
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Catalog No. ABIN2665173
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2665172 BCA Mouse IgG1 kappa Log in to see 8D4-8 10

General

Antigen Interleukin 4 (IL4) Antibodies
Reactivity Human
(392), (208), (50), (34), (24), (20), (19), (14), (11), (11), (9), (9), (6), (6), (6), (6), (5), (2), (2), (1), (1)
Host Mouse
(266), (217), (204), (7), (6), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-4 antibody is un-conjugated
(85), (52), (32), (22), (21), (12), (12), (8), (8), (8), (8), (8), (6), (6), (6), (6), (6), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (1), (1)
Application Biochemical Assay (BCA)
(387), (374), (255), (126), (56), (46), (43), (39), (39), (23), (22), (22), (15), (10), (9), (8), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Pubmed 10 references available
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Product Details anti-IL-4 Antibody

Target Details IL-4 Application Details Handling ProductDetails: References for anti-IL-4 antibody (ABIN2665173) Images
Cross-Reactivity Chimpanzee, Cynomolgus, Rhesus Monkey, Baboon
Purification The antibody was purified by affinity chromatography.
Clone 8D4-8
Isotype IgG1 kappa

Target Details IL-4

Product Details anti-IL-4 Antibody Application Details Handling ProductDetails: References for anti-IL-4 antibody (ABIN2665173) Images back to top
Antigen
Alternative Name IL-4 (IL4 Antibody Abstract)
Background IL-4 is a pleiotropic cytokine that is produced by activated T cells mast cells and basophils. IL-4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naive CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10 and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. The 8D4-8 antibody can neutralize the bioactivity of natural or recombinant IL-4.
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation

Application Details

Product Details anti-IL-4 Antibody Target Details IL-4 Handling ProductDetails: References for anti-IL-4 antibody (ABIN2665173) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL-4 Antibody Target Details IL-4 Application Details ProductDetails: References for anti-IL-4 antibody (ABIN2665173) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

ProductDetails: References for anti-IL-4 antibody (ABIN2665173)

Product Details anti-IL-4 Antibody Target Details IL-4 Application Details Handling Images back to top
Background publications

Gong, Shao, Wang, Chen, Huang, Yao, Zhan, Sicard, Wang, Chen: "Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection." in: Blood, Vol. 113, Issue 4, pp. 837-45, 2009

Hickie, Bansal, Kirk, Lloyd, Martin: "A twin study of the etiology of prolonged fatigue and immune activation." in: Twin research : the official journal of the International Society for Twin Studies, Vol. 4, Issue 2, pp. 94-102, 2001

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000

Heeger, Greenspan, Kuhlenschmidt, Dejelo, Hricik, Schulak, Tary-Lehmann: "Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 2267-75, 1999

Jason, Archibald, McDonald, Hart, Rheanppumikankit, Tansuphwaswadikul, Byrd, Larned, Han, Green, Jarvis: "Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections." in: Clinical and diagnostic laboratory immunology, Vol. 6, Issue 1, pp. 73-8, 1999

Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, 1996

Boulay, Paul: "The interleukin-4 family of lymphokines." in: Current opinion in immunology, Vol. 4, Issue 3, pp. 294-8, 1992

Dullens, De Wit: "Cancer treatment with interleukins 1, 4 and 6 and combinations of cytokines: a review." in: In vivo (Athens, Greece), Vol. 5, Issue 6, pp. 567-70, 1992

Bird, Wadhwa, Thorpe: "Development of immunoassays for human interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived molecules." in: Cytokine, Vol. 3, Issue 6, pp. 562-7, 1992

Paul: "Interleukin-4: a prototypic immunoregulatory lymphokine." in: Blood, Vol. 77, Issue 9, pp. 1859-70, 1991

Images

Product Details anti-IL-4 Antibody Target Details IL-4 Application Details Handling ProductDetails: References for anti-IL-4 antibody (ABIN2665173) back to top
Supplier Images
ELISA image for anti-Interleukin 4 (IL4) antibody (ABIN2665173) anti-Interleukin 4 (IL4) antibody