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|Application / Reactivity||Human|
|Biochemical Assay (BCA)||2 Antibodies|
|Blocking Antibody (Inhibition)||7 Antibodies|
|Dot Blot (DB)||5 Antibodies|
|ELISA (Capture)||3 Antibodies|
|ELISA (Detection)||4 Antibodies|
|ELISpot (Capture) (ELISPOT (Capture))||2 Antibodies|
|ELISpot (Detection) (ELISPOT (Detection))||2 Antibodies|
|Enzyme Immunoassay (EIA)||8 Antibodies|
|Flow Cytometry (FACS)||90 Antibodies|
|Functional Studies (Func)||11 Antibodies|
|Immunoassay (IA)||2 Antibodies|
|Immunocytochemistry (ICC)||4 Antibodies|
|Immunofluorescence (IF)||9 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||1 Antibodies|
|Immunohistochemistry (IHC)||61 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||10 Antibodies|
|Antigen||Interleukin 4 (IL4) Antibodies|
|Conjugate||This IL-4 antibody is un-conjugated Alternatives|
Biochemical Assay (BCA)
|10 references available|
|Supplier||Log in to see|
Product Details anti-IL-4 AntibodyTarget Details IL-4 Application Details Handling References for anti-IL-4 Antibody (ABIN2665173) Images
|Cross-Reactivity||Chimpanzee, Cynomolgus, Rhesus Monkey, Baboon|
|Purification||The antibody was purified by affinity chromatography.|
Target Details IL-4Product Details anti-IL-4 Antibody Application Details Handling References for anti-IL-4 Antibody (ABIN2665173) Images back to top
|Alternative Name||IL-4 (IL4 Antibody Abstract)|
|Background||IL-4 is a pleiotropic cytokine that is produced by activated T cells mast cells and basophils. IL-4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naive CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10 and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. The 8D4-8 antibody can neutralize the bioactivity of natural or recombinant IL-4.|
|Research Area||Cytokines, Immunology, Virology, Inflammation, Cancer|
Application DetailsProduct Details anti-IL-4 Antibody Target Details IL-4 Handling References for anti-IL-4 Antibody (ABIN2665173) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-4 Antibody Target Details IL-4 Application Details References for anti-IL-4 Antibody (ABIN2665173) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL-4 Antibody (ABIN2665173)Product Details anti-IL-4 Antibody Target Details IL-4 Application Details Handling Images back to top
Gong, Shao, Wang et al.: "Phosphoantigen-activated V gamma 2V delta 2 T cells antagonize IL-2-induced CD4+CD25+Foxp3+ T regulatory cells in mycobacterial infection." in: Blood, Vol. 113, Issue 4, pp. 837-45, 2009 (PubMed).
Hickie, Bansal, Kirk et al.: "A twin study of the etiology of prolonged fatigue and immune activation." in: Twin research : the official journal of the International Society for Twin Studies, Vol. 4, Issue 2, pp. 94-102, 2001 (PubMed).
Yoshino, Ami, Terao et al.: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, 2000 (PubMed).
Heeger, Greenspan, Kuhlenschmidt et al.: "Pretransplant frequency of donor-specific, IFN-gamma-producing lymphocytes is a manifestation of immunologic memory and correlates with the risk of posttransplant rejection episodes." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 4, pp. 2267-75, 1999 (PubMed).
Jason, Archibald, McDonald et al.: "Immune determinants of organism and outcome in febrile hospitalized Thai patients with bloodstream infections." in: Clinical and diagnostic laboratory immunology, Vol. 6, Issue 1, pp. 73-8, 1999 (PubMed).
Prussin, Metcalfe: "Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies." in: Journal of immunological methods, Vol. 188, Issue 1, pp. 117-28, 1996 (PubMed).
Paul: "Interleukin-4: a prototypic immunoregulatory lymphokine." in: Blood, Vol. 77, Issue 9, pp. 1859-70, 1991 (PubMed).
Dullens, De Wit: "Cancer treatment with interleukins 1, 4 and 6 and combinations of cytokines: a review." in: In vivo (Athens, Greece), Vol. 5, Issue 6, pp. 567-70, 1992 (PubMed).
Bird, Wadhwa, Thorpe: "Development of immunoassays for human interleukin 3 and interleukin 4, some of which discriminate between different recombinant DNA-derived molecules." in: Cytokine, Vol. 3, Issue 6, pp. 562-7, 1992 (PubMed).
Boulay, Paul: "The interleukin-4 family of lymphokines." in: Current opinion in immunology, Vol. 4, Issue 3, pp. 294-8, 1992 (PubMed).
ImagesProduct Details anti-IL-4 Antibody Target Details IL-4 Application Details Handling References for anti-IL-4 Antibody (ABIN2665173) back to top