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|Antigen||Interleukin 4 (IL4) Antibodies|
|Reactivity||Cow (Bovine), Dog (Canine), Goat, Mustelid, Pig (Porcine), Sheep (Ovine) Alternatives|
|Conjugate||This IL-4 antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|2 references available|
|Supplier||Log in to see|
Product Details anti-IL-4 AntibodyTarget Details IL-4 Application Details Handling References for anti-IL-4 Antibody (ABIN317378) Images
|Specificity||This antibody recognises bovine interleukin 4.|
|Characteristics||Synonyms: IL-4, BSF1, Lymphocyte stimulatory factor 1, Binetrakin, Pitrakinra, B-cell stimulatory factor1|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
Target Details IL-4Product Details anti-IL-4 Antibody Application Details Handling References for anti-IL-4 Antibody (ABIN317378) Images back to top
|Alternative Name||Interleukin-4 / IL4 (IL4 Antibody Abstract)|
|Background||IL4 is a pleiotropic cytokine produced by activated T cells, mast cells and basophils. It is a ligand for Interleukin 4 receptor. The Interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. IL4 elicits many different biological responses, but has two dominant functions. The first is regulating differentiation of naive CD4+ T cell to the Th2 type. Th2 cells produce IL4, IL5, IL10 and IL13, which tend to favor a humoral immune response while suppressing a cell mediated immune response controlled by Th1 cells. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. The second is regulating IgE and IgG1 production by B cells. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Synonyms: B-cell stimulatory factor 1, BSF1, Binetrakin, IL-4, Lymphocyte stimulatory factor 1, Pitrakinra|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Proton Transport, Activated T Cell Proliferation|
Application DetailsProduct Details anti-IL-4 Antibody Target Details IL-4 Handling References for anti-IL-4 Antibody (ABIN317378) Images back to top
Flow Cytometry: 1/5.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-4 Antibody Target Details IL-4 Application Details References for anti-IL-4 Antibody (ABIN317378) Images back to top
|Reconstitution||Reconstitute with 1 mL distilled water|
|Buffer||Phosphate buffered saline pH 7.4 containing 0.09 % Sodium Azide, 1 % Bovine Serum Albumin|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
|Expiry Date||12 months|
References for anti-IL-4 Antibody (ABIN317378)Product Details anti-IL-4 Antibody Target Details IL-4 Application Details Handling Images back to top
Pedersen, Castelruiz, Jacobsen, Aasted: "Identification of monoclonal antibodies that cross-react with cytokines from different animal species." in: Veterinary immunology and immunopathology, Vol. 88, Issue 3-4, pp. 111-22, 2002
Aasted, Bach, Nielsen, Lind: "Cytokine profiles in peripheral blood mononuclear cells and lymph node cells from piglets infected in utero with porcine reproductive and respiratory syndrome virus." in: Clinical and diagnostic laboratory immunology, Vol. 9, Issue 6, pp. 1229-34, 2002