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Mouse (Murine) IL-4 ELISA Kit for Sandwich ELISA - ABIN411300
Wang, Deng, Jiang, Yao: The natural plant product sophocarpine ameliorates dextran sodium sulfate-induced colitis in mice by regulating cytokine balance. in International journal of colorectal disease 2012
Show all 21 Pubmed References
Human IL-4 ELISA Kit for Sandwich ELISA - ABIN411299
Wang, Feng, Shi, Hao, Yang, Zhang, Kong: Silencing of miR155 promotes the production of inflammatory mediators in Guillain-Barré syndrome in vitro. in Inflammation 2013
Show all 23 Pubmed References
Rat (Rattus) IL-4 ELISA Kit for Sandwich ELISA - ABIN411301
Arai, Nomura, Villaret, DeWaal Malefijt, Seiki, Yoshida, Minoshima, Fukuyama, Maekawa, Kudoh: Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. in Journal of immunology (Baltimore, Md. : 1950) 1989
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Mouse (Murine) IL-4 ELISA Kit for Sandwich ELISA - ABIN625147
Herrmann, Andreeff, Gruss, Brach, Lübbert, Mertelsmann: Interleukin-4 inhibits growth of multiple myelomas by suppressing interleukin-6 expression. in Blood 1991
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Rat (Rattus) IL-4 ELISA Kit for Sandwich ELISA - ABIN625203
Arafa, Mohammad, Atteia: Fenugreek seed powder mitigates cadmium-induced testicular damage and hepatotoxicity in male rats. in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2014
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Mouse (Murine) IL-4 ELISA Kit for Sandwich ELISA - ABIN415512
Mandhane, Shah, Bahekar, Mehetre, Pawar, Bagad, Chidrewar, Rao, Rajamannar: Characterization of anti-inflammatory properties and evidence for no sedation liability for the novel antihistamine SUN-1334H. in International archives of allergy and immunology 2009
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Human IL-4 ELISA Kit for Sandwich ELISA - ABIN625024
Meltzer, Standley: Modeled repetitive motion strain and indirect osteopathic manipulative techniques in regulation of human fibroblast proliferation and interleukin secretion. in The Journal of the American Osteopathic Association 2008
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Human IL-4 ELISA Kit for Sandwich ELISA - ABIN1446053
Mohapatra, Saxena, Gandhi, Koner, Singh, Ray: Does vitamin D mediate inhibition of epithelial ovarian cancer by modulating cytokines? in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2015
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Chicken IL-4 ELISA Kit for Sandwich ELISA - ABIN414103
Lu, Wu, Zhang, Feng, Dong, Chu, Liu, Peng, Liu, Ma, Hou, Tang: Immunopotentiators Improve the Efficacy of Oil-Emulsion-Inactivated Avian Influenza Vaccine in Chickens, Ducks and Geese. in PLoS ONE 2016
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Dog (Canine) IL-4 ELISA Kit for Sandwich ELISA - ABIN414169
Pantaleo, Piccinno, Roncetti, Mutinati, Rizzo, Sciorsci: Evaluation of serum concentrations of interleukin (IL)-4, IL-10, and IL-12 during pregnancy in bitches. in Theriogenology 2013
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Results from these two large randomized aerobic exercise intervention trials suggest that aerobic exercise does not alter IL-10 (show IL10 ELISA Kits) or IL-4 in a manner consistent with chronic disease and cancer prevention.
The results highlight the importance of the inflammatory mediators, IFN-gamma (show IFNG ELISA Kits) and TLR4 (show TLR4 ELISA Kits), in the pathogenesis of aseptic loosening; increased pro-inflammatory status was associated with early time to revision, whereas IL-4 correlated with longer implant survival
upon ligation of the T-cell antigen receptor (TCR), the TCR associates with and transactivates CXCR4 (show CXCR4 ELISA Kits) via phosphorylation of S339-CXCR4 (show CXCR4 ELISA Kits) in order to activate a PREX1 (show PREX1 ELISA Kits)-Rac1-signaling pathway that stabilizes interleukin-2(IL-2 (show IL2 ELISA Kits)), IL-4, and IL-10 (show IL10 ELISA Kits) messenger RNA (mRNA) transcripts.
IL-4 signaling up-regulates the IL-25 (show IL25 ELISA Kits) axis in human monocytic cells, and IL-25 (show IL25 ELISA Kits) may provide autocrine signals in monocytes and macrophages to sustain IL-17Rb expression and predispose to alternative activation.
IL4 VNTR B2 allele was only significantly associated with overall adiposity status before adjusting for ethnicity.
Our results showed the role of IL4 in promoting breast cancer aggressiveness
These data identified the IL-4/CXCL12 (show CXCL12 ELISA Kits) loop as a previously unrecognized pathway involved in lymphoid stroma polarization and as a potential therapeutic target in Follicular lymphoma patients.
IL-4 genetic variations associated with susceptibility to or protection against chronic periodontitis are directly associated with influencing the response of immune cells to periodontopathogens
in HIV/AIDS patients under antiretroviral therapy, IL-4 and IL-10 (show IL10 ELISA Kits) levels were significantly lower in lipodystrophy vs. non-lipodystrophy
autologous CD4 (show CD4 ELISA Kits)(+) T cells that are exposed to EVs from CD40 (show CD40 ELISA Kits)/IL-4-stimulated CLL cells exhibit enhanced migration, immunological synapse signaling, and interactions with tumor cells.
Findings suggest that interleukin 4 (IL-4) affects anti-tumor immunity and constitutes an attractive therapeutic target to reduce immune suppression in the tumor microenvironment.
this study shows that environmental IL-4 plays a role in conditioning early thymic progenitors lineage choice, which would impact T cell development
IL-4 and IL-13 (show IL13 ELISA Kits) are required to effectively polarize macrophages/dendritic cells to an M2a phenotype and to promote recovery from acute kidney injury.
These observations suggest that IL-4 and IL-13 (show IL13 ELISA Kits) likely operate through the Heteroreceptor and influence Th17 cells to convert to Th1 (show HAND1 ELISA Kits) cells and to acquire increased sensitivity to suppression, leading to control of immune-mediated CNS inflammation.
this study shows that eosinophils subvert host resistance to an intracellular pathogen by instigating non-protective IL-4 in CCR2(-/-) mice
findings show that during intestinal helminth infection, IL-4 derived from T follicular helper cells is required for IgE class switching and plasmablast formation
Data suggest that Il4 (usually released from helper T-cells) induces Cox1 (show COX1 ELISA Kits) in macrophages at post-transcriptional level; activation of Ampk (show PRKAA1 ELISA Kits) (catalytic subunit Prkaa1 (show PRKAA1 ELISA Kits)) by metformin blocks Il4-dependent induction of Cox1 (show COX1 ELISA Kits) and blocks macrophage polarization/activation. (Il4 = interleukin-4; Cox1 (show COX1 ELISA Kits) = cyclooxygenase 1 (show PTGS1 ELISA Kits); Ampk (show PRKAA1 ELISA Kits) = AMP-activated protein kinase (show PRKAA2 ELISA Kits))
IL-4 is required for the development of ex-Foxp3 (show FOXP3 ELISA Kits) T helper 2 cells.
conclude that a state of haploinsufficiency for the Il4 gene locus is specifically relevant for IL-4-dependent IgE responses to allergens with the amount of IL-4 produced in the hemizygous condition falling close to the threshold required for switching to IgE production
priming of T helper cells by IL-6 (show IL6 ELISA Kits)-deficient antigen-presenting dendritic cells preferentially leads to accumulation of a subset of Follicular helper T cells characterized by high expression of GATA3 (show GATA3 ELISA Kits) and IL-4.
These results support pregnancy as type 2 immune response biased, with increases of IFN-gamma (show IFNG ELISA Kits) occurring after parturition and an increase in IL-4 production before calving.
IL-4 may play a role in coordinating the adrenal response to inflammatory stress.
T helper (Th) type 2 cell cytokine IL-4 modulates airway contraction by secreting matrix metalloproteinase-1 (show MMP1 ELISA Kits) from the smooth muscle cells via phosphatidylinositol 3-kinase activation and changing cell-to-matrix interactions.
IL-4- and IL-10 (show IL10 ELISA Kits)-producing invariant NKT (show SLC22A6 ELISA Kits) cells inhibit the Th1 (show TH1L ELISA Kits) cell response, but not the Th17 cell response
IL-4 induced activation of Akt/SREBP-1/lipid biosynthesis in EC, resulting in protection against membrane attack complex and melittin, in association with mitochondrial protection.
There was no significant difference of IL-4 production between fresh and frozen peripheral blood mononuclear cells.
The endothelium and subendothelium of porcine iliac arteries that are transduced with recombinant pig IL-4 are effectively protected from complement-dependent immediate injury after perfusion with human blood.
unlike in humans and mice, porcine IL-4 blocks antibody and IL-6 (show IL6 ELISA Kits) secretion and suppresses antigen-stimulated proliferation of B cells
Data indicate that animals exposed to high lead concentration, the levels of IFNgamma and IFNgamma/IL-4 ratio were significantly lower than those exposed to its low concentration.
IL-4 and STAT6 (show STAT6 ELISA Kits) are related to the pathogenesis of allergic rhinitis and may be the main factors for eosinophil infiltration in allergic rhinitis.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 (show TH1L ELISA Kits) biased, interferon-gamma (show IFNG ELISA Kits) production is qualitatively similar to adult horses, and regulatory IL-10 (show IL10 ELISA Kits) production by T cells is mature.
This study showed that pronounced lung eosinophilia in horses can be transient, abate without specific treatment, and in this instance, lack correlation to upregulation of expression of either IL-4 or IL-5 (show IL5 ELISA Kits).
Low Sociable animals showed alterations in lymph node expression of the immunoregulatory cytokine genes IL4.
Mycobacterial infections of macaques induce mRNA encoding a variant IL-4 that functions as a growth factor to promote expansion of 4-hydroxy-3-methyl-but-2-enyl pyrophosphate-specific Vgamma2Vdelta2 T effector cells.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
, B cell growth factor 1
, B_cell stimulatory factor 1
, lymphocyte stimulatory factor 1
, B-cell IgG differentiation factor
, B-cell growth factor 1
, B-cell stimulatory factor 1
, IGG1 induction factor
, B-cell IGG differentiation factor
, Lymphocyte stimulatory factor 1