anti-Human IL-6 Receptor antibody for ELISA

Recommended IL-6 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin-6 Receptor (IL6R) Antibodies
  • IL6R
  • il-6ra
  • CD126
  • IL-6R-1
  • IL-6RA
  • IL6Q
  • IL6RA
  • IL6RQ
  • gp80
  • IL6R1
  • Il6ra
  • IL-6Ralpha
  • IL-6R
  • Il6r
  • interleukin 6 receptor
  • interleukin 6 receptor-like
  • interleukin 6 receptor, alpha
  • IL6R
  • il6r
  • Il6r
  • LOC100347752
  • Il6ra
Epitope
AA 21-121
24
19
17
15
12
7
7
6
6
6
5
5
5
5
5
3
3
2
2
1
1
1
1
1
1
1
1
Reactivity
Human
182
97
46
1
Host
Mouse
130
93
52
23
2
Clonality
Monoclonal
Conjugate
This IL-6 Receptor antibody is un-conjugated
26
15
15
10
10
9
7
7
5
5
5
5
4
3
3
3
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
131
128
102
71
40
24
24
22
17
13
10
10
9
8
8
6
4
2
2
2
2
2
1
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Catalog No. ABIN395681
$ 450.00
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
12.499065 ABIN561464 ELISA WB Mouse IgG2b kappa AA 21-120, partial Log in to see 2G6
12.499065 ABIN517054 ELISA WB Mouse IgG1 kappa AA 21-120, partial Log in to see 1E11
1 ABIN185570 ELISA WB Goat Internal Region Log in to see Polyclonal 1
1 ABIN959335 IHC (p) ELISA WB Rabbit IgG Log in to see Polyclonal
1 ABIN1996689 ELISA Rabbit IgG AA 1-365, Extracellular Domain Log in to see Polyclonal 1
1 ABIN1996691 ELISA Rabbit IgG AA 1-365, Extracellular Domain Log in to see Polyclonal 1
1 ABIN255790 ICC FACS IHC (fro) IF IP IHC ELISA Mouse IgG1 Log in to see B-R6
1 ABIN2656901 ELISA WB APC Mouse IgG1 kappa Log in to see UV4 4
1 ABIN2688946 ELISA Biotin Mouse IgG1, kappa Log in to see M182 15
1 ABIN206746 FACS IHC (fro) IP ELISA Mouse IgG1 Log in to see B-R6
1 ABIN208781 FACS Neut ELISA Mouse IgG1, kappa Log in to see B-R6
1 ABIN2877896 Func FACS IHC (fro) IP ELISA Mouse IgG1 Log in to see B-R6
1 ABIN1828212 ELISA WB Mouse IgG2b, kappa AA 21-120 Log in to see 2G6
1 ABIN208181 FACS IHC (fro) IP ELISA Mouse IgG1 Log in to see
1 ABIN2688945 FACS ELISA Mouse IgG1, kappa Log in to see M5 12
1 ABIN2465845 ELISA WB Goat Internal Region Log in to see Polyclonal
1 ABIN327362 FACS Neut ELISA WB Mouse IgG1 Log in to see 17506
1 ABIN2624201 ELISA WB Biotin Rabbit IgG AA 216-356 Log in to see Polyclonal
1 ABIN2624206 ELISA WB FITC Rabbit IgG AA 216-356 Log in to see Polyclonal
1 ABIN208780 ICC FACS ELISA Mouse IgG1, kappa Log in to see

General

Antigen Interleukin-6 Receptor (IL6R) Antibodies
Epitope AA 21-121
(24), (19), (17), (15), (12), (7), (7), (6), (6), (6), (5), (5), (5), (5), (5), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(182), (97), (46), (1)
Host Mouse
(130), (93), (52), (23), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-6 Receptor antibody is un-conjugated
(26), (15), (15), (10), (10), (9), (7), (7), (5), (5), (5), (5), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application ELISA, Western Blotting (WB)
(131), (128), (102), (71), (40), (24), (24), (22), (17), (13), (10), (10), (9), (8), (8), (6), (4), (2), (2), (2), (2), (2), (1)
Pubmed 5 references available
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Product Details anti-IL-6 Receptor Antibody

Target Details IL-6 Receptor Application Details Handling ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681) Images
Specificity IL6R (NP_000556, 21 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Purification This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen IL6R (NP_000556, 21 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K
Clone 2G6
Isotype IgG2b kappa

Target Details IL-6 Receptor

Product Details anti-IL-6 Receptor Antibody Application Details Handling ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681) Images back to top
Antigen
Alternative Name IL6R (IL6R Antibody Abstract)
Background Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1
Molecular Weight 51548 DA
Gene ID 12406
NCBI Accession NP_000556
Research Area Cancer, Cell Structure
Pathways JAK-STAT Signaling, Autophagy, Growth Factor Binding

Application Details

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681) Images back to top
Application Notes ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000
Comment

Background: Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Restrictions For Research Use only

Handling

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681) Images back to top
Buffer PBS with 0.09% (w/v) sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Expiry Date 6 months

ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681)

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Background publications

Rodríguez-Rodríguez, Lamas, Varadé, López-Romero, Tornero-Esteban, Abasolo, de la Concha, Jover, Urcelay, Fernández-Gutiérrez: "Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity." in: Rheumatology international, Vol. 31, Issue 3, pp. 409-13, 2011

Romero, Friel, Velez Edwards, Kusanovic, Hassan, Mazaki-Tovi, Vaisbuch, Kim, Erez, Chaiworapongsa, Pearce, Bartlett, Salisbury, Anant, Vovis, Lee, Gomez, Behnke, Oyarzun, Tromp, Williams, Menon: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010

Bottema, Kerkhof, Reijmerink, Thijs, Smit, van Schayck, Brunekreef, van Oosterhout, Postma, Koppelman: "Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 2, pp. 338-46, 346.e1-10, 2010

Lamas, Rodríguez-Rodríguez, Varadé, López-Romero, Tornero-Esteban, Abasolo, Urcelay, Fernández-Gutiérrez: "Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis." in: The Journal of rheumatology, Vol. 37, Issue 8, pp. 1579-81, 2010

Images

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling ProductDetails: References for anti-IL-6 Receptor antibody (ABIN395681) back to top
Supplier Images
ELISA image for anti-Interleukin-6 Receptor (IL6R) (AA 21-121) antibody (ABIN395681) Detection limit for recombinant GST tagged IL6R is approximately 0.1 ng/mL as a captu...