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|Application / Reactivity||Human|
|ELISA (Capture)||2 Antibodies|
|ELISA (Detection)||1 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies|
|Flow Cytometry (FACS)||60 Antibodies|
|Functional Studies (Func)||8 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies|
|Immunofluorescence (IF)||9 Antibodies|
|Immunohistochemistry (IHC)||22 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||14 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||5 Antibodies|
|Immunoprecipitation (IP)||13 Antibodies|
|Intracellular Flow Cytometry (ICFC)||4 Antibodies|
|Mass Cytometry (CyTOF)||1 Antibodies|
|Neutralization (Neut)||10 Antibodies|
|Western Blotting (WB)||48 Antibodies|
|Antigen||Interleukin-6 Receptor (IL6R) Antibodies|
|Epitope||AA 21-121 Alternatives|
|Conjugate||This IL-6 Receptor antibody is un-conjugated Alternatives|
ELISA, Western Blotting (WB)
|5 references available|
|Supplier||Log in to see|
Product Details anti-IL-6 Receptor AntibodyTarget Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN395681) Images
|Specificity||IL6R (NP_000556, 21 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.|
|Purification||This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||IL6R (NP_000556, 21 a.a. ~ 121 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K|
Target Details IL-6 ReceptorProduct Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN395681) Images back to top
|Alternative Name||IL6R (IL6R Antibody Abstract)|
|Background||Synonyms: Serine protease inhibitor J6, 47 kDa heat shock protein, Collagen-binding protein, Colligin, Serpin H1,Hsp47, Cbp1, Serpinh1|
|Molecular Weight||51548 DA|
|Research Area||Cancer, Cell Structure|
Application DetailsProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor Antibody (ABIN395681) Images back to top
|Application Notes||ELISA ~~ 1ug/ml~3ng/ml Western blot ~~ 1:500~1000|
Background: Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. The protein encoded by this gene is a subunit of the receptor complex for IL6. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor Antibody (ABIN395681) Images back to top
|Buffer||PBS with 0.09% (w/v) sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles|
|Expiry Date||6 months|
References for anti-IL-6 Receptor Antibody (ABIN395681)Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).
Rodríguez-Rodríguez, Lamas, Varadé et al.: "Plasma soluble IL-6 receptor concentration in rheumatoid arthritis: associations with the rs8192284 IL6R polymorphism and with disease activity." in: Rheumatology international, Vol. 31, Issue 3, pp. 409-13, 2011 (PubMed).
Bailey, Xie, Do et al.: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, 2010 (PubMed).
Bottema, Kerkhof, Reijmerink et al.: "Gene-gene interaction in regulatory T-cell function in atopy and asthma development in childhood." in: The Journal of allergy and clinical immunology, Vol. 126, Issue 2, pp. 338-46, 346.e1-10, 2010 (PubMed).
Lamas, Rodríguez-Rodríguez, Varadé et al.: "Influence of IL6R rs8192284 polymorphism status in disease activity in rheumatoid arthritis." in: The Journal of rheumatology, Vol. 37, Issue 8, pp. 1579-81, 2010 (PubMed).
ImagesProduct Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor Antibody (ABIN395681) back to top