anti-Human IL-6 Receptor antibody for Intracellular Flow Cytometry

Recommended IL-6 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin-6 Receptor (IL6R) Antibodies
  • IL6R
  • il-6ra
  • CD126
  • IL-6R-1
  • IL-6RA
  • IL6Q
  • IL6RA
  • IL6RQ
  • gp80
  • IL6R1
  • Il6ra
  • IL-6Ralpha
  • IL-6R
  • Il6r
  • interleukin 6 receptor
  • interleukin 6 receptor-like
  • interleukin 6 receptor, alpha
  • IL6R
  • il6r
  • Il6r
  • LOC100347752
  • Il6ra
Reactivity
Human
199
88
45
1
Host
Mouse
145
95
45
21
2
Clonality
Monoclonal
Conjugate
This IL-6 Receptor antibody is conjugated to Biotin
25
17
15
12
10
9
7
7
5
5
5
5
4
4
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Intracellular Flow Cytometry (ICFC)
136
135
102
71
40
24
24
22
19
13
11
10
10
8
8
7
4
2
2
2
2
2
1
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Catalog No. ABIN2660807
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2664187 ICFC Mouse IgG1 kappa Log in to see UV4 3
1 ABIN2660808 ICFC Biotin Mouse IgG1 kappa Log in to see UV4 3
1 ABIN2664188 ICFC Mouse IgG1 kappa Log in to see UV4 3

General

Antigen Interleukin-6 Receptor (IL6R) Antibodies
Reactivity Human
(199), (88), (45), (1)
Host Mouse
(145), (95), (45), (21), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL-6 Receptor antibody is conjugated to Biotin
(25), (17), (15), (12), (10), (9), (7), (7), (5), (5), (5), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Intracellular Flow Cytometry (ICFC)
(136), (135), (102), (71), (40), (24), (24), (22), (19), (13), (11), (10), (10), (8), (8), (7), (4), (2), (2), (2), (2), (2), (1)
Pubmed 3 references available
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Product Details anti-IL-6 Receptor Antibody

Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2660807) Images
Purification The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.
Clone UV4
Isotype IgG1 kappa

Target Details IL-6 Receptor

Product Details anti-IL-6 Receptor Antibody Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2660807) Images back to top
Antigen
Alternative Name CD126 (IL6R Antibody Abstract)
Background CD126 is an 80 kD IL-6 receptor α chain also known as IL-6R. It is a member of the immunoglobulin superfamily that is expressed on plasma cells, T cells, activated B cells, monocytes, granulocytes, hepatocytes, epithelial cells, and fibroblasts. Functional IL-6 receptors are formed by the non-covalent association of CD126 and the IL-6 receptor β chain (CD130 or gp130). CD126 binds IL-6 with low affinity but does not signal. The β chain (gp130, CD130) does not bind IL-6 by itself but associates with the α-chain/IL-6 complex to initiate signal transduction. IL-6 binding to the receptor complex results in the stimulation of B and T cells, and hematopoietic precursor proliferation and differentiation. A soluble form of CD126 has been found in human serum.
Pathways JAK-STAT Signaling, Autophagy, Growth Factor Binding

Application Details

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Handling References for anti-IL-6 Receptor antibody (ABIN2660807) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details References for anti-IL-6 Receptor antibody (ABIN2660807) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL-6 Receptor antibody (ABIN2660807)

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling Images back to top
Background publications

Boulanger, Chow, Brevnova, Garcia: "Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." in: Science (New York, N.Y.), Vol. 300, Issue 5628, pp. 2101-4, 2003

Taga, Kishimoto: "Gp130 and the interleukin-6 family of cytokines." in: Annual review of immunology, Vol. 15, pp. 797-819, 1997

Gaillard, Bataille, Brailly, Zuber, Yasukawa, Attal, Maruo, Taga, Kishimoto, Klein: "Increased and highly stable levels of functional soluble interleukin-6 receptor in sera of patients with monoclonal gammopathy." in: European journal of immunology, Vol. 23, Issue 4, pp. 820-4, 1993

Images

Product Details anti-IL-6 Receptor Antibody Target Details IL-6 Receptor Application Details Handling References for anti-IL-6 Receptor antibody (ABIN2660807) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin-6 Receptor (IL6R) antibody (Biotin) (ABIN2660807) anti-Interleukin-6 Receptor (IL6R) antibody (Biotin)
Flow Cytometry (FACS) image for anti-Interleukin-6 Receptor (IL6R) antibody (Biotin) (ABIN2660807) anti-Interleukin-6 Receptor (IL6R) antibody (Biotin) (Image 2)