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IL-12p35 suppresses lymphocyte proliferation, induces expansion of IL-10 (show IL10 Proteins)-expressing and IL-35-expressing B cells and ameliorates autoimmune uveitis.
IL-35-transduced adipocyte-derived mesenchymal stem cells in vivo can enhance proliferation of CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) Treg cells and suppress the function of effector T cells such as T helper (Th) 1 (show TH1L Proteins), Th2 and Th17 cells and may reduce the development of allograft rejection.
findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.
this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
These results suggest a correlation between CRMP2 (show DPYSL2 Proteins) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (show APP Proteins) accumulation stage in AD model mice.
Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.
Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.
Deficiency of IL-12p35 limited AMI (show CFD Proteins)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes
IL-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.
There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.
baseline serum IL-12 levels were significantly higher in those pediatric hematopoietic stem cell transplantation recipients who did not develop acute graft versus host disease
circulating mir-21 and expression of the IL-12p35 gene were observed significantly downregulated in current smokers with CAD.
Simultaneous elevated circulating levels of IL-18 (show IL18 Proteins) and IL-12 increased the event rate after 2 years in Coronary Artery Disease patients, independent of hyperglycemia
Epstein Barr Virus miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of naive CD4 (show CD4 Proteins)(+) T cells to Th1 (show TH1L Proteins) cells.
HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.
assembly-induced folding is key in IL-12 family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 cytokine
The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.
Importantly, treatment of NK cells from HIV-infected patients with IL-12 reversed the multiple defects in binding, granule polarization, perforin (show PRF1 Proteins) content, and perforin (show PRF1 Proteins) release and restored anticryptococcal activity.
Our results from a large-scale population-based study suggest that there are differences in levels of adiponectin, IL-10 (show IL10 Proteins) and IL-12 between neonates that later develop T1D compared to their healthy controls
this study shows that that IL-12 and IL-4 (show IL4 Proteins) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation
The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6 (show IL6 Proteins), IL-12]
This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12a p35 subunit
, interleukin-12 subunit alpha
, interleukin 12 p35 subunit
, IL-12, subunit p35
, IL35 subunit
, NF cell stimulatory factor chain 1
, NK cell stimulatory factor chain 1
, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12, p35
, interleukin-12 alpha chain
, natural killer cell stimulatory factor 1, 35 kD subunit
, interleukin 12 35kDa subunit
, interleukin 12 polypeptide 35
, natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35
, interleukin 12B
, interleukin-12 p35 subunit
, IL-12 p35
, interleukin 12
, Cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12 35kD subunit
, IL-12p35 subunit