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Browse our IL12A Proteins (IL12A)

Full name:
Interleukin 12 alpha Proteins (IL12A)
On www.antibodies-online.com are 34 Interleukin 12 alpha (IL12A) Proteins from 11 different suppliers available. Additionally we are shipping IL12A Antibodies (94) and IL12A Kits (39) and many more products for this protein. A total of 176 IL12A products are currently listed.
Synonyms:
CLMF, Il-12 p35, IL-12A, IL-12p35, IL12, IL12p35, Ll12a, NFSK, NKSF1, P35
list all proteins Gene Name GeneID UniProt
IL12A 16159 P43431
IL12A 84405 Q9R103
IL12A 3592 P29459

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IL12A Proteins (IL12A) by Origin

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Top referenced IL12A Proteins

  1. Human IL12A Protein expressed in Human Cells - ABIN2001929 : Sieburth, Jabs, Warrington, Li, Lasota, LaForgia, Kelleher, Huebner, Wasmuth, Wolf: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. in Genomics 1992 (PubMed)
    Show all 5 references for ABIN2001929

  2. Human IL12A Protein expressed in Human Cells - ABIN2001928 : Gearing, Cosman: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. in Cell 1991 (PubMed)
    Show all 5 references for ABIN2001928

  3. Cynomolgus IL12A Protein expressed in Human Cells - ABIN2010104 : Thierfelder, van Deursen, Yamamoto, Tripp, Sarawar, Carson, Sangster, Vignali, Doherty, Grosveld, Ihle: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. in Nature 1996 (PubMed)
    Show all 5 references for ABIN2010104

More Proteins for IL12A Interaction Partners

Mouse (Murine) Interleukin 12 alpha (IL12A) interaction partners

  1. IL-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  2. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  3. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  4. The IL-12 response by dendritic cells against S. aureus is highly growth phase dependent.

  5. These results provide a new pathway of Th1 (show HAND1 Proteins) response regulation where IL-12 secreted by dendritic cellss is consumed by a sub-population of IL-12Rbeta2-expressing Treg cells.

  6. IL-12p35 has a protective role against pulmonary infection with methicillin-resistant Staphylococcus aureus.

  7. TBI (show TBPL1 Proteins)-induced IL12 augments Tc17 cell-mediated tumor immunity and underline the substantial implications of in vitro preparation of antitumor Tc17 cells with IL12 in the design of T-cell immunotherapies

  8. Interleukin-12-producing CD103 (show ITGAE Proteins)+ CD11b (show ITGAM Proteins)- CD8 (show CD8A Proteins)+ dendritic cells are responsible for eliciting gut (show GUSB Proteins) intraepithelial lymphocyte response against Encephalitozoon cuniculi.

  9. the PI3K pathway mediated IL-12 inhibition but did not interfere with the inhibition of IL-23 (show IL23A Proteins) or stimulation of IL-10 (show IL10 Proteins).

  10. Interferon-gamma (IFN-gamma (show IFNG Proteins)) and interleukin-12 (IL-12) levels in the tumors and plasma were significantly enhanced after processing with recombinant mouse CCL19 (show CCL19 Proteins).

Human Interleukin 12 alpha (IL12A) interaction partners

  1. the functional single nucleotide polymorphism IL-12A rs2243115 GG genotype may increase the risk of rheumatoid arthritis in rheumatoid factor negative patients

  2. Low IL12 expression levels are associated with Acute Leukemia.

  3. Study indicated that the rs568408 variation in IL-12A gene could influence disease susceptibility, and was associated with the severity of oral lichen planus in our East Chinese cohort.

  4. These results for the first time demonstrate a role of Cdk5 (show CDK5 Proteins)/p35 (show ANXA1 Proteins) in the regulation of cell cycle progression modulated by TGF-beta1 (show TGFB1 Proteins).

  5. IL-35 was elevated in bone marrow of adult AML (show RUNX1 Proteins) patients and this increase was correlated with the clinical stages of malignancy, suggesting that IL-35 is involved in pathogenesis of AML (show RUNX1 Proteins).

  6. p41 (show EPB41 Proteins) fragment is also shown to reduce the secretion of interleukin-12 (IL-12/p70 (show ANXA6 Proteins)) during the subsequent maturation of treated dendritic cells.

  7. Peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 and IL-4 (show IL4 Proteins) after LPS (show IRF6 Proteins) stimulation.

  8. Findings demonstrate that IL-12 is increased significantly in chronic hepatitis B patients and that viral protein HBx induces IL-12 expression in hepatocytes through the activation of the PI3K (show PIK3CA Proteins)/Akt (show AKT1 Proteins) pathway.

  9. IL-35 Is Involved in the Pathogenesis of Guillain-Barre Syndrome Through Its Influence on the Function of CD4 (show CD4 Proteins)+ T Cells

  10. Gene-gene interaction analysis showed that subjects carrying the IL-12A rs568408AG/AA and IL-12B (show IL12B Proteins) rs3212227AA genotypes had a 2.40-fold increased risk of CRC (show CALR Proteins) (OR = 2.40; 95 % CI, 1.14-5.07)

Cow (Bovine) Interleukin 12 alpha (IL12A) interaction partners

  1. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6 (show IL6 Proteins), IL-12]

IL12A Protein Profile

Protein Summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

Alternative names and synonyms associated with IL12A

  • interleukin 12a (Il12a)
  • interleukin 12A (Il12a)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • CLMF protein
  • Il-12 p35 protein
  • IL-12A protein
  • IL-12p35 protein
  • IL12 protein
  • IL12p35 protein
  • Ll12a protein
  • NFSK protein
  • NKSF1 protein
  • P35 protein

Protein level used designations for Interleukin 12 alpha Proteins (IL12A)

CLMF p35 , IL-12 subunit p35 , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12a p35 subunit , interleukin-12 subunit alpha , IL-12A , interleukin 12 p35 subunit , IL-12, subunit p35 , IL35 subunit , NF cell stimulatory factor chain 1 , NK cell stimulatory factor chain 1 , cytotoxic lymphocyte maturation factor 1, p35 , interleukin 12, p35 , interleukin-12 alpha chain , natural killer cell stimulatory factor 1, 35 kD subunit , interleukin 12 35kDa subunit , interleukin 12 polypeptide 35 , natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35 , interleukin 12B , interleukin-12 p35 subunit , IL-12 p35 , interleukin 12 , Cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12 35kD subunit , IL-12p35 subunit

GENE ID SPECIES
16159 Mus musculus
84405 Rattus norvegicus
3592 Homo sapiens
281856 Bos taurus
403977 Canis lupus familiaris
397053 Sus scrofa
100034215 Equus caballus
493741 Felis catus
100861293 Capra hircus
703205 Macaca mulatta
407090 Gallus gallus
443064 Ovis aries
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