Browse our IL12A Proteins (IL12A)

Full name:
Interleukin 12 alpha Proteins (IL12A)
On www.antibodies-online.com are 35 Interleukin 12 alpha (IL12A) Proteins from 11 different suppliers available. Additionally we are shipping IL12A Antibodies (92) and IL12A Kits (42) and many more products for this protein. A total of 179 IL12A products are currently listed.
Synonyms:
CLMF, Il-12 p35, IL-12A, IL-12p35, IL12, IL12p35, Ll12a, NFSK, NKSF1, P35
list all proteins Gene Name GeneID UniProt
IL12A 16159 P43431
IL12A 84405 Q9R103
IL12A 3592 P29459

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IL12A Proteins (IL12A) by Origin

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Top referenced IL12A Proteins

  1. Human IL12A Protein expressed in Human Cells - ABIN2001929 : Sieburth, Jabs, Warrington, Li, Lasota, LaForgia, Kelleher, Huebner, Wasmuth, Wolf: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. in Genomics 1992 (PubMed)
    Show all 5 references for 2001929

  2. Rhesus Monkey IL12A Protein expressed in Human Cells - ABIN2010104 : Gearing, Cosman: Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor. in Cell 1991 (PubMed)
    Show all 5 references for 2010104

  3. Human IL12A Protein expressed in Human Cells - ABIN2001928 : Thierfelder, van Deursen, Yamamoto, Tripp, Sarawar, Carson, Sangster, Vignali, Doherty, Grosveld, Ihle: Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. in Nature 1996 (PubMed)
    Show all 5 references for 2001928

More Proteins for IL12A Interaction Partners

Mouse (Murine) Interleukin 12 alpha (IL12A) interaction partners

  1. findings show that IL-12 and other proinflammatory cytokines transduce signals through the TCR signalosome in a manner that requires Fyn activity and self-peptide-MHC (self-pMHC) interactions.

  2. this study shows that a systemic IL-12 primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis

  3. These results suggest a correlation between CRMP2 (show DPYSL2 Proteins) phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta (show APP Proteins) accumulation stage in AD model mice.

  4. Data show that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) expressing plasmid downregulates the expression of pro-inflammatory cytokines and upregulates the expression of anti-inflammatory cytokines.

  5. Data suggest that interleukin-35 (Epstein-Barr virus-induced gene 3 (EBI3) and the interleukin-12 Subunit p35 (p35) subunit) contributes to the increased susceptibility to secondary pneumococcal pneumonia.

  6. Deficiency of IL-12p35 limited AMI (show CFD Proteins)-induced cardiac injury by promoting pro-angiogenesis and anti-inflammatory functions of monocytes

  7. IL-12 immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  8. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet.

  9. Irradiation-induced IL-6 (show IL6 Proteins) can decrease IL-12 production through the inhibition of C-Rel (show NFkBP65 Proteins) phosphorylation by the IL-6 (show IL6 Proteins)/STAT3 (show STAT3 Proteins) signaling pathway.

  10. The IL-12 response by dendritic cells against S. aureus is highly growth phase dependent.

Human Interleukin 12 alpha (IL12A) interaction partners

  1. Epstein Barr Virus miRNAs collectively and specifically suppress release of proinflammatory cytokines such as IL-12, repress differentiation of naive CD4 (show CD4 Proteins)(+) T cells to Th1 (show TH1L Proteins) cells.

  2. HLA-B51 is a primary association marker in predisposition to Behcet disease, with IL-23R and IL12A being the additional strongest loci.

  3. assembly-induced folding is key in IL-12 family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 cytokine

  4. The plasma levels of interleukin-35 were significantly higher in the hepatocellular carcinoma patients than the controls.

  5. Importantly, treatment of NK cells from HIV-infected patients with IL-12 reversed the multiple defects in binding, granule polarization, perforin (show PRF1 Proteins) content, and perforin (show PRF1 Proteins) release and restored anticryptococcal activity.

  6. Our results from a large-scale population-based study suggest that there are differences in levels of adiponectin (show ADIPOQ Proteins), IL-10 (show IL10 Proteins) and IL-12 between neonates that later develop T1D compared to their healthy controls

  7. this study shows that that IL-12 and IL-4 (show IL4 Proteins) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation

  8. The results of this case-control study suggest that IL-12A, IL-12B (show IL12B Proteins), IL12RB1 (show IL12RB1 Proteins), IL12RB2 (show IL12RB2 Proteins) and IL23R (show IL23R Proteins) make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations

  9. suberoylanilide hydroxamic acid significantly inhibited IL-12p40 and IL-23p19 mRNA synthesis and did not change IL-12p35 mRNA transcription.

  10. this study shows that IL-12A gene polymorphism contributes to the risk of hepatocellular carcinoma on top of chronic hepatitis C virus infection in Egyptian patients

Cow (Bovine) Interleukin 12 alpha (IL12A) interaction partners

  1. The results showed that the expression of TNF-alpha (show TNF Proteins), iNOS (show NOS2 Proteins), and IL-6 (show IL6 Proteins) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 was unaffected.[IL-6 (show IL6 Proteins), IL-12]

IL12A Protein Profile

Protein Summary

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity.

Alternative names and synonyms associated with IL12A

  • interleukin 12a (Il12a)
  • interleukin 12A (Il12a)
  • interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35) (IL12A)
  • CLMF protein
  • Il-12 p35 protein
  • IL-12A protein
  • IL-12p35 protein
  • IL12 protein
  • IL12p35 protein
  • Ll12a protein
  • NFSK protein
  • NKSF1 protein
  • P35 protein

Protein level used designations for Interleukin 12 alpha Proteins (IL12A)

CLMF p35 , IL-12 subunit p35 , cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12a p35 subunit , interleukin-12 subunit alpha , IL-12A , interleukin 12 p35 subunit , IL-12, subunit p35 , IL35 subunit , NF cell stimulatory factor chain 1 , NK cell stimulatory factor chain 1 , cytotoxic lymphocyte maturation factor 1, p35 , interleukin 12, p35 , interleukin-12 alpha chain , natural killer cell stimulatory factor 1, 35 kD subunit , interleukin 12 35kDa subunit , interleukin 12 polypeptide 35 , natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35 , interleukin 12B , interleukin-12 p35 subunit , IL-12 p35 , interleukin 12 , Cytotoxic lymphocyte maturation factor 35 kDa subunit , interleukin 12 35kD subunit , IL-12p35 subunit

GENE ID SPECIES
16159 Mus musculus
84405 Rattus norvegicus
3592 Homo sapiens
281856 Bos taurus
403977 Canis lupus familiaris
397053 Sus scrofa
100034215 Equus caballus
493741 Felis catus
100861293 Capra hircus
703205 Macaca mulatta
407090 Gallus gallus
443064 Ovis aries
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