Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Show all synonyms
this study shows that a systemic IL-12 (show IL12A Antibodies) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (show IL12A Antibodies) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (show IL6 Antibodies) can decrease IL-12 (show IL12A Antibodies) production through the inhibition of C-Rel (show NFkBP65 Antibodies) phosphorylation by the IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway.
The IL-12 (show IL12A Antibodies) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (show IL12A Antibodies) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Antibodies) or stimulation of IL-10 (show IL10 Antibodies).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 Antibodies) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 Antibodies) (TLR3 (show TLR3 Antibodies)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 Antibodies) [TRIF (show RNF138 Antibodies)] responsive), C/EBPbeta (show CEBPB Antibodies) (TLR7 (show TLR7 Antibodies)-MyD88 (show MYD88 Antibodies) responsive), and JunB (show JUNB Antibodies) (all responsive).
These findings reveal a critical role for IL-12 (show IL12A Antibodies) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
The systemic IL-10 (show IL10 Antibodies)/IL-12 (show IL12A Antibodies) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 Antibodies) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A Antibodies)-negative phenotype.
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Antibodies)/8 and TLR-9 (show TLR9 Antibodies) stimulation, which could potentially affect their response to vaccination and viral infection.
IL-12B -1188 C allele may be a protective factor against asthma in East Asians
The low expression of HDAC3 (show HDAC3 Antibodies) and overexpession of inflammatory cytokines (IL-18 (show IL18 Antibodies), IL-12 (show IL12A Antibodies) and TNF-alpha (show TNF Antibodies)) in intrahepatic cholestasis of pregnancy may be involved in liver cell apoptosis and in the pathophysiology of the disease.
Polymorphisms of IFNG (show IFNG Antibodies), IL12B and IL12RB1 (show IL12RB1 Antibodies) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Identification of PARP-1 (show PARP1 Antibodies) as a unique regulator of Il12b transcription in response to inflammatory insults in an allele-differentiating manner
Pre-incubation with IL-12 (show IL12A Antibodies) was able to restore IFN-gamma (show IFNG Antibodies) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.
NOD2 (show NOD2 Antibodies) rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.
assembly-induced folding is key in IL-12 (show IL12A Antibodies) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A Antibodies) cytokine
IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients
this study shows that that IL-12 (show IL12A Antibodies) and IL-4 (show IL4 Antibodies) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation
The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, IL-12 p40
, IL-12 subunit p40
, IL-23 subunit p40
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin-12 subunit beta
, interleukin-12 p40 subunit
, interleukin 12 p40 subunit
, interleukin-12 beta chain
, interleukin-12 p40 chain
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, interleukin 12, p40
, natural killer cell stimulatory factor, 40 kD subunit