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Browse our anti-Interleukin 12 beta (IL12B) Antibodies

Full name:
anti-Interleukin 12 beta Antibodies (IL12B)
On www.antibodies-online.com are 0 Interleukin 12 beta (IL12B) Antibodies from different suppliers available. A total of 0 Interleukin 12 beta products are currently listed.
Synonyms:
CLMF, CLMF2, IL-12, IL-12.p40, IL-12B, Il-12p40, Il12p40, NKSF, NKSF2, p40
list all antibodies Gene Name GeneID UniProt
Anti-Mouse IL12B IL12B 16160 P43432
Anti-Human IL12B IL12B 3593 P29460

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More Antibodies against Interleukin 12 beta Interaction Partners

Mouse (Murine) Interleukin 12 beta (IL12B) interaction partners

  1. Irradiation-induced IL-6 (show IL6 Antibodies) can decrease IL-12 (show IL12A Antibodies) production through the inhibition of C-Rel (show NFkBP65 Antibodies) phosphorylation by the IL-6 (show IL6 Antibodies)/STAT3 (show STAT3 Antibodies) signaling pathway.

  2. The IL-12 (show IL12A Antibodies) response by dendritic cells against S. aureus is highly growth phase dependent.

  3. the PI3K pathway mediated IL-12 (show IL12A Antibodies) inhibition but did not interfere with the inhibition of IL-23 (show IL23A Antibodies) or stimulation of IL-10 (show IL10 Antibodies).

  4. Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.

  5. this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 Antibodies) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 Antibodies) (TLR3 (show TLR3 Antibodies)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 Antibodies) [TRIF (show RNF138 Antibodies)] responsive), C/EBPbeta (show CEBPB Antibodies) (TLR7 (show TLR7 Antibodies)-MyD88 (show MYD88 Antibodies) responsive), and JunB (show JUNB Antibodies) (all responsive).

  6. These findings reveal a critical role for IL-12 (show IL12A Antibodies) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.

  7. our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.

  8. The systemic IL-10 (show IL10 Antibodies)/IL-12 (show IL12A Antibodies) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 Antibodies) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A Antibodies)-negative phenotype.

  9. the assembled p40 (show LANCL1 Antibodies)-CD5L (show CD5L Antibodies) heterodimer does not recapitulate the biological activity of IL-12 (show IL12A Antibodies).

  10. The immune-enhancing effect of the Cronobacter sakazakii ES2 (show DGCR14 Antibodies) phage results in the activation of nuclear factor-kappaB and dendritic cell maturation via the activation of IL-12p40 in the mouse bone marrow.

Rhesus Monkey Interleukin 12 beta (IL12B) interaction partners

  1. In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 Antibodies)/8 and TLR-9 (show TLR9 Antibodies) stimulation, which could potentially affect their response to vaccination and viral infection.

Human Interleukin 12 beta (IL12B) interaction partners

  1. The IL23R (show IL23R Antibodies) polymorphisms rs10889677, rs7517847, and the IL12B polymorphism rs3212227 are not associated with multiple sclerosis risk.

  2. IL-12 (show IL12A Antibodies) immunomodulation delays the onset of lethal peritoneal disease of ovarian cancer.

  3. the IL-12B rs3212227 AC and AC+CC genotypes are associated with rheumatoid arthritis risk in older patients,rheumatoid factor positive patients and anti-cyclic peptide antibodies negative patients

  4. High serum IL-12 (show IL12A Antibodies) levels associated with increased densities of peritumoral CD8 (show CD8A Antibodies)(+) T cells, intraepithelial CD3 (show CD3 Antibodies)(+) T cells and intratumoral neutrophils, while high serum CCL4 (show CCL4 Antibodies) levels associated with increased densities of peritumoral CD68 (show CD68 Antibodies)(+) cells

  5. Human IL-21 (show IL17C Antibodies)+IFN-gamma (show IFNG Antibodies)+CD4 (show CD4 Antibodies)+ T cells in nasal polyps are regulated by IL-12 (show IL12A Antibodies).

  6. No association was observed for IL-12B and IFN-gamma (show IFNG Antibodies) polymorphisms between the rheumatoid arthritis patients and controls.

  7. These observations indicate a HDAC1 (show HDAC1 Antibodies)-mediated IL-12B gene expression suppression by live, virulent Mycobacterium tuberculosis to subvert the immune system to survive and replicate in the host.

  8. Peripheral blood mononuclear cells from severe asthmatic children release lower amounts of IL-12 (show IL12A Antibodies) and IL-4 (show IL4 Antibodies) after LPS (show IRF6 Antibodies) stimulation.

  9. Findings demonstrate that IL-12 (show IL12A Antibodies) is increased significantly in chronic hepatitis B patients and that viral protein HBx induces IL-12 (show IL12A Antibodies) expression in hepatocytes through the activation of the PI3K (show PIK3CA Antibodies)/Akt (show AKT1 Antibodies) pathway.

  10. 8 SNPs (rs10045431, rs11167764, rs3212227, rs6556412, rs6556416, rs6871626, rs6887695 and rs7709212) were genotyped in Han ankylosing spondylitis patients and controls. rs6871626 may be associated AS susceptibility and activity.

Interleukin 12 beta (IL12B) Antigen Profile

Antigen Summary

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

Alternative names and synonyms associated with Interleukin 12 beta (IL12B)

  • interleukin 12b (Il12b) antibody
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B) antibody
  • CLMF antibody
  • CLMF2 antibody
  • IL-12 antibody
  • IL-12.p40 antibody
  • IL-12B antibody
  • Il-12p40 antibody
  • Il12p40 antibody
  • NKSF antibody
  • NKSF2 antibody
  • p40 antibody

Protein level used designations for IL12B

CLMF p40 , IL-12 p40 , IL-12 subunit p40 , IL-23 subunit p40 , cytotoxic lymphocyte maturation factor 40 kDa subunit , interleukin-12 subunit beta , IL-12B , interleukin-12 p40 subunit , interleukin 12 p40 subunit , interleukin-12 beta chain , interleukin-12 p40 chain , IL12, subunit p40 , NK cell stimulatory factor chain 2 , interleukin 12, p40 , natural killer cell stimulatory factor, 40 kD subunit

GENE ID SPECIES
16160 Mus musculus
443472 Ovis aries
768273 Felis catus
694747 Macaca mulatta
3593 Homo sapiens
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