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Human IL12B ELISA Kit for Sandwich ELISA - ABIN411311
Becher, Durell, Noelle: Experimental autoimmune encephalitis and inflammation in the absence of interleukin-12. in The Journal of clinical investigation 2002
Show all 12 Pubmed References
Mouse (Murine) IL12B ELISA Kit for Sandwich ELISA - ABIN1672845
Cua, Sherlock, Chen, Murphy, Joyce, Seymour, Lucian, To, Kwan, Churakova, Zurawski, Wiekowski, Lira, Gorman, Kastelein, Sedgwick: Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. in Nature 2003
Show all 11 Pubmed References
Mouse (Murine) IL12B ELISA Kit for Sandwich ELISA - ABIN1305259
Chougnet, Freitag, Schito, Thomas, Sher, Shearer: In vivo CD40-CD154 (CD40 ligand) interaction induces integrated HIV expression by APC in an HIV-1-transgenic mouse model. in Journal of immunology (Baltimore, Md. : 1950) 2001
Show all 7 Pubmed References
Human IL12B ELISA Kit for Sandwich ELISA - ABIN625009
Chowdhury, Ahmed, Choudhuri, Sen, Hazra, Pal, Bhattacharya, Bahar: Alteration of serum inflammatory cytokines in active pulmonary tuberculosis following anti-tuberculosis drug therapy. in Molecular immunology 2014
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Human IL12B ELISA Kit for Sandwich ELISA - ABIN1446078
Vilisaar, Kawabe, Braitch, Aram, Furtun, Fahey, Chopra, Tanasescu, Tighe, Gran, Pothoulakis, Constantinescu: Reciprocal Regulation of Substance P and IL-12/IL-23 and the Associated Cytokines, IFNγ/IL-17: A Perspective on the Relevance of This Interaction to Multiple Sclerosis. in Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2015
Show all 3 Pubmed References
Human IL12B ELISA Kit for Sandwich ELISA - ABIN2684574
Sieburth, Jabs, Warrington, Li, Lasota, LaForgia, Kelleher, Huebner, Wasmuth, Wolf: Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. in Genomics 1992
Show all 3 Pubmed References
Horse (Equine) IL12B ELISA Kit for Sandwich ELISA - ABIN416683
Duran, Willenbrock, Müller, Nolte, Feige, Murua Escobar: Establishment and evaluation of a bead-based luminex assay allowing simultaneous quantification of equine IL-12 and IFN-?. in Anticancer research 2013
Rat (Rattus) IL12B ELISA Kit for Sandwich ELISA - ABIN416325
Hou, Zhu, Sun, Ma, Wang, Timothy, Chen, Yan, Lei, Han, Chen, Cai, Guan: Serum Proteomics Analysis in Rats of Immunosuppression Induced by Chronic Stress. in Scandinavian journal of immunology 2016
this study shows that a systemic IL-12 (show IL12A ELISA Kits) primes intestinal cells that became more prone to develop inflammatory responses, which is long-lasting because intestinal cells maintain their inflammatory potential and their ability to aggravate colitis
this study shows that endosomal signalling by Lactobacillus acidophilus that leads to IL-12 (show IL12A ELISA Kits) production is inhibited by TLR stimulation from the plasma membrane
Irradiation-induced IL-6 (show IL6 ELISA Kits) can decrease IL-12 (show IL12A ELISA Kits) production through the inhibition of C-Rel (show NFkBP65 ELISA Kits) phosphorylation by the IL-6 (show IL6 ELISA Kits)/STAT3 (show STAT3 ELISA Kits) signaling pathway.
The IL-12 (show IL12A ELISA Kits) response by dendritic cells against S. aureus is highly growth phase dependent.
the PI3K pathway mediated IL-12 (show IL12A ELISA Kits) inhibition but did not interfere with the inhibition of IL-23 (show IL23A ELISA Kits) or stimulation of IL-10 (show IL10 ELISA Kits).
Data indicate that sera from treated with cholesterol-p40 (Il12b)-siRNA contained significantly reduced concentrations of p40.
this study demonstrates viral RNA analog-induced transcription synergy of Il6 (show IL6 ELISA Kits) and Il12b via IFN regulatory factor (IRF)1 (show IRF1 ELISA Kits) (TLR3 (show TLR3 ELISA Kits)-TIR domain-containing adaptor inducing IFN-beta (show TICAM1 ELISA Kits) [TRIF (show RNF138 ELISA Kits)] responsive), C/EBPbeta (show CEBPB ELISA Kits) (TLR7 (show TLR7 ELISA Kits)-MyD88 (show MYD88 ELISA Kits) responsive), and JunB (show JUNB ELISA Kits) (all responsive).
These findings reveal a critical role for IL-12 (show IL12A ELISA Kits) in shaping the anti-inflammatory biofilm milieu by promoting MDSC recruitment.
our results suggest that IL-12p40 acts as a negative regulator of autoimmune cholangitis in IL-2Ralpha-/- mice. Compared to IL-2Ralpha-/- mice, p40-/-IL-2Ralpha-/- mice develop liver fibrosis and reduced colitis.
The systemic IL-10 (show IL10 ELISA Kits)/IL-12 (show IL12A ELISA Kits) axis is skewed after burn injury with infection as indicated by a significant elevation in serum IL-10 (show IL10 ELISA Kits) and polarization of neutrophils into an anti-inflammatory IL-12 (show IL12A ELISA Kits)-negative phenotype.
Polymorphisms of IFNG (show IFNG ELISA Kits), IL12B and IL12RB1 (show IL12RB1 ELISA Kits) genes in paracoccidioidomycosis Brazilian patients do not affect the susceptibility or resistance to the disease.
Identification of PARP-1 (show PARP1 ELISA Kits) as a unique regulator of Il12b transcription in response to inflammatory insults in an allele-differentiating manner
Pre-incubation with IL-12 (show IL12A ELISA Kits) was able to restore IFN-gamma (show IFNG ELISA Kits) production and the cytotoxicity capacities of NK cells. This cytokine may therefore be considered as a potential treatment candidate in traumatic brain injury patients with immune suppression.
NOD2 (show NOD2 ELISA Kits) rs3135500 and IL12B rs1368439 SNPs were not genetic risk factors for colorectal cancer in the studied Iranian population.
assembly-induced folding is key in IL-12 (show IL12A ELISA Kits) family biogenesis and secretion; the identification of essential disulfide bonds that underlie this process lays the basis for a simplified yet functional IL-12 (show IL12A ELISA Kits) cytokine
IL-12B gene polymorphisms were not related with rheumatoid arthritis (RA). However, rs6887695 was associated with RA in Asian patients
this study shows that that IL-12 (show IL12A ELISA Kits) and IL-4 (show IL4 ELISA Kits) govern group 2 innate lymphoid cells functional identity and that their imbalance results in the perpetuation of type 1 or type 2 inflammation
The data suggested the association of IL12B with the psoriasis, however no evidence was observed for the epistatic effect of IL12B with HLA-Cw6 among the psoriasis patients in India.
In summary, this meta-analysis finds that IL6 (show IL6 ELISA Kits) rs1800795 and IL18 (show IL18 ELISA Kits) rs1946518 polymorphisms decrease the risk of BD. However, IL12B rs3212227 increases BD susceptibility. Further large-scale investigation of this association is necessary.
Suggest Il12B SNPs as genetic marker of disease severity in Takayasu arteritis severity.
The results showed that the expression of TNF-alpha (show TNF ELISA Kits), iNOS (show NOS2 ELISA Kits), and IL-6 (show IL6 ELISA Kits) in alveolar macrophages was up-regulated by stimulation with the recombinant Mce4A protein of M. bovis; in contrast, expression of IL-12 (show IL12A ELISA Kits) was unaffected.[IL-6 (show IL6 ELISA Kits), IL-12 (show IL12A ELISA Kits)]
study investigated hypothesis that CD40 (show CD40 ELISA Kits) signalling is impaired in Mycobacterium avium subspecies paratuberculosis(MAP)-infected macrophages; propose that MAP interferes with gene expression of iNOS (show NOS2 ELISA Kits) and IL-12p40 genes downstream of p38 (show MAPK14 ELISA Kits)
In rhesus macaques plasmacytoid dendritic cells in peripheral blood express IL-12p40 upon TLR-7 (show TLR7 ELISA Kits)/8 and TLR-9 (show TLR9 ELISA Kits) stimulation, which could potentially affect their response to vaccination and viral infection.
Data show that cysteine significantly reduced the expression of pro-inflammatory cytokines, including TNF-alpha (show TNF ELISA Kits), IL-6 (show IL6 ELISA Kits), IL-12p40, IL-1beta (show IL1B ELISA Kits), and resulted in increased expression of the apoptosis initiator caspase-8 (show CASP8 ELISA Kits) and bcl2L1 (show BCL2L1 ELISA Kits).
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.
, Cytotoxic lymphocyte maturation factor 40 kDa subunit
, IL-12 subunit p40
, Interleukin-12 subunit beta
, CLMF p35
, IL-12 subunit p35
, cytotoxic lymphocyte maturation factor 35 kDa subunit
, interleukin 12B
, interleukin-12 p35 subunit
, interleukin-12 subunit alpha
, IL-12 p40
, IL-23 subunit p40
, cytotoxic lymphocyte maturation factor 40 kDa subunit
, interleukin-12 subunit beta
, interleukin-12 p40
, interleukin-12 p40 subunit
, IL12, subunit p40
, NK cell stimulatory factor chain 2
, interleukin 12, p40
, interleukin-12 beta chain
, natural killer cell stimulatory factor, 40 kD subunit
, interleukin 12 40kDa subunit
, interleukin 12 p40 subunit
, interleukin-12 p40 chain
, IL-12 p40 subunit