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Browse our IL12RB1 Proteins (IL12RB1)

Full name:
Interleukin 12 Receptor beta 1 Proteins (IL12RB1)
On www.antibodies-online.com are 15 Interleukin 12 Receptor beta 1 (IL12RB1) Proteins from 7 different suppliers available. Additionally we are shipping IL12RB1 Antibodies (73) and IL12RB1 Kits (7) and many more products for this protein. A total of 104 IL12RB1 products are currently listed.
Synonyms:
CD212, IL-12R, IL-12R-BETA1, IL-12R[b], IL12RB, IL12RB1
list all proteins Gene Name GeneID UniProt
Rat IL12RB1 IL12RB1 171333  
IL12RB1 3594 P42701
IL12RB1 16161 Q60837

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IL12RB1 Proteins (IL12RB1) by Origin

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Top referenced IL12RB1 Proteins

  1. Human IL12RB1 Protein expressed in Human Cells - ABIN2004503 : Grimwood, Gordon, Olsen, Terry, Schmutz, Lamerdin, Hellsten, Goodstein, Couronne, Tran-Gyamfi, Aerts, Altherr, Ashworth, Bajorek, Black, Branscomb, Caenepeel, Carrano, Caoile, Chan, Christensen et al.: The DNA sequence and biology of human chromosome 19. ... in Nature 2004 (PubMed)
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More Proteins for IL12RB1 Interaction Partners

Cow (Bovine) Interleukin 12 Receptor beta 1 (IL12RB1) interaction partners

  1. Four SNPs in IFNGR2 (show IFNGR2 Proteins), IL12RB1, IL12RB2 (show IL12RB2 Proteins), and IL23R (show IL23R Proteins) were found to be associated with the MAP infection status of the resource population.

Human Interleukin 12 Receptor beta 1 (IL12RB1) interaction partners

  1. Truncated IL12rbeta1/Fc is a novel fusion protein for specific binding multiple forms of p40 subunit to exert potent anti-inflammatory effects.

  2. the introduction of RNA-DNA differences into an individual's IL12RB1 mRNA repertoire is a novel determinant of IL12 (show IL12A Proteins)/23 sensitivity.

  3. we describe cosegregation of a heterozygous germline defect in IL12RB1 and gastric cancer development in a family with IL-12Rbeta1 deficiency

  4. individual variability in IL12RB1 function is introduced at the epigenetic, genomic polymorphism, and mRNA splicing levels [review]

  5. Early coupled up-regulation of IL12RB1 in CD8 (show CD8A Proteins)+ central memory and effector T cells result in better clinical outcomes in liver transplant recipients.

  6. Genetic variations of IL-12B (show IL12B Proteins), IL-12Rbeta1, IL-12Rbeta2 in Behcet's disease and VKH syndrome.

  7. The IL-23 (show IL23A Proteins)/IL-23R (show IL23R Proteins)/IL-12Rbeta1 complex formation does not follow the classical "site I-II-III" architectural paradigm.

  8. SNP rs2305743 in IL12RB1 was associated with systemic sclerosis.

  9. A review of the molecular genetics of all known IL12RB1 mutations and variants.

  10. IL12Rbeta1 expression is lacking on CD8 (show CD8A Proteins)+ T and natural killer (NK) cell surface in a 33-year-old patient with Mycobacterium tilburgii infection.

Mouse (Murine) Interleukin 12 Receptor beta 1 (IL12RB1) interaction partners

  1. the data support a model wherein IL12Rbeta1DeltaTM is a secreted product of il12rb1 that promotes resistance to M. tuberculosis infection by potentiating T(H) cells response to IL-12 (show IL12A Proteins).

  2. Although they share a common subunit, IL-23 (show IL23A Proteins) and IL-12 (show IL12A Proteins) receptors are not expressed on the same cell populations.

  3. IL12RB1 is essential for human resistance to Mycobacterium tuberculosis infection

  4. IL-12p40 is induced rapidly in response to Francisella tularensis LVS and is required for DC migration through an IL-12Rbeta1-IL-12(p40 (show IL12B Proteins))2 dependent mechanism.

  5. IL-12Rbeta1DeltaTM represents a novel regulator of IL12Rbeta1-dependent dendritic cell function and of the immune response to Mycobacterium tuberculosis.

  6. IL-12R beta 1 deficiency results in decreased viral replication and inflammation following coxsackievirus B3-induced myocarditis, decreasing IL-1 beta (show IL1B Proteins) and IL-18 (show IL18 Proteins) in the heart.

  7. The binding domain in the IL-12 receptor beta 1 cytoplasmic region has been mapped to sphingosine kinase 2 (show SPHK2 Proteins).

  8. Expression of the IL-12 (show IL12A Proteins) beta 1 receptor is upregulated in both microglia and splenic macrophages.

  9. IL-12 receptor beta 1 subunit plays an essential role in the activation and differentiation of Th1 (show HAND1 Proteins)-type myelin oligodendrocyte glycoprotein (MOG (show MOG Proteins))-specific autoreactive T cells in vivo.

  10. IL-12 receptor beta 1 (Rbeta1) mediates IL-12 p40 (show IL12B Proteins) homodimer (p80 (show COIL Proteins))-dependent macrophage chemotaxis and inhibition of the p80 (show COIL Proteins)-Rbeta1 interaction, a novel anti-inflammatory strategy to manipulate inflammation associated with respiratory viral infection.

IL12RB1 Protein Profile

Protein Summary

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative names and synonyms associated with IL12RB1

  • interleukin 12 receptor, beta 1 (Il12rb1)
  • interleukin 12 receptor, beta 1 (IL12RB1)
  • CD212 protein
  • IL-12R protein
  • IL-12R-BETA1 protein
  • IL-12R[b] protein
  • IL12RB protein
  • IL12RB1 protein

Protein level used designations for IL12RB1

interleukin-12 receptor subunit beta-1 , interleukin 12 receptor, beta 1 , IL12 receptor beta 1 subunit , interleukin-12 receptor subunit beta-1-like , IL-12 receptor beta component , IL-12 receptor subunit beta-1 , IL-12R subunit beta-1 , interleukin-12 receptor beta-1 chain , IL-12R-beta-1 , Interleukin-12 receptor beta-1 chain precursor (IL-12R-beta1) (Interleukin-12 receptor beta) (IL-12 receptor beta component)

GENE ID SPECIES
171333 Rattus norvegicus
484828 Canis lupus familiaris
524299 Bos taurus
574199 Macaca mulatta
100271900 Sus scrofa
100435478 Pongo abelii
100474774 Ailuropoda melanoleuca
3594 Homo sapiens
16161 Mus musculus
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