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|Antigen||Interleukin 2 (IL2) Antibodies|
|Reactivity||Bird (Avian), Chicken, Mammalian Alternatives|
|Conjugate||This IL2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Functional Studies (Func)
|1 reference available|
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Product Details anti-IL2 AntibodyTarget Details IL2 Application Details Handling References for anti-IL2 antibody (ABIN181831) Images
|Specificity||This antibody SM1540A recognises natural and recombinant IL-2 expressed in either E.coli or CHO cells. Clone 4F12 neutralises the proliferative activity of rchIL-2 and recognises a different epitope to Clone 10E7 product code (Cat.-No SM1539A). This antibody can be used as the Neutralising antibody for recombinant Chicken IL-2 bioassays (See Product code SA028).|
|Purification||Affinity Chromatography on Protein G|
|Immunogen||Recombinant Chicken IL-2. Remarks: Spleen cells from immunised mice were fused with cells of the mouse Sp2/0-Ag myeloma cell line.|
Target Details IL2Product Details anti-IL2 Antibody Application Details Handling References for anti-IL2 antibody (ABIN181831) Images back to top
|Alternative Name||Interleukin-2 / IL2 (IL2 Antibody Abstract)|
|Background||Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation|
Application DetailsProduct Details anti-IL2 Antibody Target Details IL2 Handling References for anti-IL2 antibody (ABIN181831) Images back to top
ELISA: 5-10g as capture antibody. Western Blot: Non-reducing conditions. Functional Assays: 2-20g/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2 Antibody Target Details IL2 Application Details References for anti-IL2 antibody (ABIN181831) Images back to top
|Buffer||PBS without preservatives, None|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody prior to reconstitution at -20 °C. Following reconstitution the antibody can be stored at 2-8 °C for one month or at -20 °C for longer.|
References for anti-IL2 antibody (ABIN181831)Product Details anti-IL2 Antibody Target Details IL2 Application Details Handling Images back to top
del Cacho, Gallego, Lee, Lillehoj, Quilez, Lillehoj, Sánchez-Acedo: "Induction of protective immunity against Eimeria tenella, Eimeria maxima, and Eimeria acervulina infections using dendritic cell-derived exosomes." in: Infection and immunity, Vol. 80, Issue 5, pp. 1909-16, 2012