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|Application / Reactivity||Human|
|Blocking Antibody (Inhibition)||8 Antibodies|
|Blocking Peptide (BP)||1 Antibodies|
|Dot Blot (DB)||4 Antibodies|
|ELISA (Capture)||4 Antibodies|
|ELISA (Detection)||3 Antibodies|
|Enzyme Immunoassay (EIA)||24 Antibodies|
|Flow Cytometry (FACS)||75 Antibodies|
|Functional Studies (Func)||18 Antibodies|
|Immunoassay (IA)||3 Antibodies|
|Immunocytochemistry (ICC)||10 Antibodies|
|Immunofluorescence (IF)||3 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||21 Antibodies|
|Immunohistochemistry (IHC)||43 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||21 Antibodies|
|Antigen||Interleukin 2 (IL2) Antibodies|
|Conjugate||This IL2 antibody is un-conjugated Alternatives|
Functional Studies (Func), Flow Cytometry (FACS), Western Blotting (WB)
|14 references available|
|Supplier||Log in to see|
Product Details anti-IL2 AntibodyTarget Details IL2 Application Details Handling References for anti-IL2 Antibody (ABIN1107821) Images
|Specificity||Recognizes both natural and recombinant Human Interleukin-2 (IL-2).|
|Cross-Reactivity (Details)||Species reactivity (tested):Human.|
|Purification||Ion Exchange Chromatography|
|Sterility||0.22 μm filtered|
|Immunogen||Natural Human IL-2|
Target Details IL2Product Details anti-IL2 Antibody Application Details Handling References for anti-IL2 Antibody (ABIN1107821) Images back to top
|Alternative Name||Interleukin-2 / IL2 (IL2 Antibody Abstract)|
|Background||Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF|
Application DetailsProduct Details anti-IL2 Antibody Target Details IL2 Handling References for anti-IL2 Antibody (ABIN1107821) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2 Antibody Target Details IL2 Application Details References for anti-IL2 Antibody (ABIN1107821) Images back to top
|Buffer||PBS without Carrier and preservatives. This product is Sterile-filtered through 0.22 μm and treated to remove endotoxins.|
|Handling Advice||DO NOT FREEZE!|
|Storage Comment||Store the antibody undiluted at 2-8 °C.|
References for anti-IL2 Antibody (ABIN1107821)Product Details anti-IL2 Antibody Target Details IL2 Application Details Handling Images back to top
Koopman, Mortier, Hofman et al.: "Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian-human immunodeficiency virus viraemia with protein/DNA combination." in: The Journal of general virology, Vol. 89, Issue Pt 2, pp. 540-53, 2008 (PubMed).
Kobari, Giarratana, Gluckman et al.: "Ex vivo expansion does not alter the capacity of umbilical cord blood CD34+ cells to generate functional T lymphocytes and dendritic cells." in: Stem cells (Dayton, Ohio), Vol. 24, Issue 9, pp. 2150-7, 2006 (PubMed).
Van Rhijn, Van den Berg, Ang et al.: "Expansion of human gammadelta T cells after in vitro stimulation with Campylobacter jejuni." in: International immunology, Vol. 15, Issue 3, pp. 373-82, 2003 (PubMed).
Frétier, Besse, Delwail et al.: "Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes." in: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 289-94, 2002 (PubMed).
Muñoz, van Seventer, Semnani et al.: "Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 278, Issue 6, pp. L1172-9, 2000 (PubMed).
Peng, Remacle, Kasran et al.: "IL-12 up-regulates CD40 ligand (CD154) expression on human T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 3, pp. 1166-72, 1998 (PubMed).
Groux, Bigler, de Vries et al.: "Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3188-93, 1998 (PubMed).
Fisfalen, Palmer, Van Seventer et al.: "Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease." in: The Journal of clinical endocrinology and metabolism, Vol. 82, Issue 11, pp. 3655-63, 1997 (PubMed).
Pilson, Levin, Desai et al.: "Bispecific humanized anti-IL-2 receptor alpha beta antibodies inhibitory for both IL-2- and IL-15-mediated proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1543-56, 1997 (PubMed).
Palmer, van Seventer: "Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 6, pp. 2654-62, 1997 (PubMed).
Kuiper, de Jong, Brouwer et al.: "Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2." in: Immunology, Vol. 83, Issue 1, pp. 38-44, 1995 (PubMed).
Picker, Singh, Zdraveski et al.: "Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry." in: Blood, Vol. 86, Issue 4, pp. 1408-19, 1995 (PubMed).
Tortorella, Schulze-Koops, Thomas et al.: "Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 1, pp. 149-62, 1995 (PubMed).
de Jong, Brouwer, Kuiper et al.: "Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 8, pp. 2795-802, 1992 (PubMed).