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anti-Human IL2 antibody for Functional Studies

Recommended IL2 Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 (IL2) Antibodies
  • Il-2
  • IL-2
  • IL2
  • il2
  • lymphokine
  • POIL2
  • TCGF
Reactivity
Human
433
223
89
18
13
7
6
4
4
3
2
2
1
1
Host
Mouse
257
254
210
17
7
4
Clonality
Monoclonal
Conjugate
This IL2 antibody is un-conjugated
93
50
49
26
21
12
10
9
6
6
5
5
4
4
4
4
4
4
4
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS), Western Blotting (WB)
422
347
175
68
60
44
43
39
38
29
23
20
15
14
11
9
7
6
6
4
4
3
2
2
2
1
1
1
1
1
1
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Catalog No. ABIN1107821
$ 533.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00087117846 ABIN116068 EIA Func IHC (p) WB Rabbit Log in to see Polyclonal 2
0.00087117846 ABIN116067 EIA Func IHC (p) WB Rabbit Log in to see Polyclonal 2
0.00087117846 ABIN263857 EIA Func Mouse IgG1 Log in to see B025M
0.00087117846 ABIN596060 Func ELISA WB Rabbit IgG Log in to see Polyclonal
0.00087117846 ABIN264491 DB Func IHC (fro) Mouse IgG2a Log in to see 297C16F11
0.00087117846 ABIN210052 Func ELISA WB Rabbit IgG Log in to see Polyclonal
0.00087117846 ABIN181648 EIA Func IHC (p) WB Goat Log in to see Polyclonal
0.00087117846 ABIN318983 Func EIA WB Rabbit IgG Log in to see Polyclonal
0.00087117846 ABIN1107822 Func EIA IP WB Rabbit IgG Log in to see Polyclonal
0.00087117846 ABIN2680387 Func Neut Mouse IgG2a kappa Log in to see AB12-3G4
0.00087117846 ABIN2474959 Func IHC (p) ELISA WB Rabbit IgG Log in to see Polyclonal 2
0.00087117846 ABIN645719 Func IP IHC ELISA WB Mouse IgG2a Log in to see
0.00087117846 ABIN1724561 ELISpot Func FACS ELISA WB Mouse IgG1 Log in to see B-G5
0.00087117846 ABIN2474961 Func ELISA WB Rabbit IgG Log in to see Polyclonal
0.00087117846 ABIN2688698 Func Mouse IgG1 Log in to see B-G5
0.00087117846 ABIN641025 Func ELISA WB Rabbit Log in to see
0.00087117846 ABIN641024 Func ELISA WB Rabbit Log in to see

Top referenced anti-IL2 antibody for Functional Studies

Similar anti-IL2 Antibodies

Application / Reactivity Human
Blocking Antibody (Inhibition) 8 Antibodies
Blocking Peptide (BP) 1 Antibodies
Dot Blot (DB) 4 Antibodies
ELISA 251 Antibodies
ELISA (Capture) 4 Antibodies
ELISA (Detection) 3 Antibodies
ELISpot 5 Antibodies
Enzyme Immunoassay (EIA) 24 Antibodies
Flow Cytometry (FACS) 94 Antibodies
Functional Studies (Func) 18 Antibodies
Immunoassay (IA) 3 Antibodies
Immunocytochemistry (ICC) 16 Antibodies
Immunofluorescence (IF) 9 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 21 Antibodies
Immunohistochemistry (IHC) 43 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 6 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 27 Antibodies

General

Antigen Interleukin 2 (IL2) Antibodies
Reactivity Human
(433), (223), (89), (18), (13), (7), (6), (4), (4), (3), (2), (2), (1), (1)
Host Mouse
(257), (254), (210), (17), (7), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2 antibody is un-conjugated
(93), (50), (49), (26), (21), (12), (10), (9), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application Functional Studies (Func), Flow Cytometry (FACS), Western Blotting (WB)
(422), (347), (175), (68), (60), (44), (43), (39), (38), (29), (23), (20), (15), (14), (11), (9), (7), (6), (6), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Pubmed 14 references available
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Product Details anti-IL2 Antibody

Target Details IL2 Application Details Handling References for anti-IL2 Antibody (ABIN1107821) Images
Specificity Recognizes both natural and recombinant Human Interleukin-2 (IL-2).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ion Exchange Chromatography
Sterility 0.22 μm filtered
Immunogen Natural Human IL-2
Clone B-G5
Isotype IgG1

Target Details IL2

Product Details anti-IL2 Antibody Application Details Handling References for anti-IL2 Antibody (ABIN1107821) Images back to top
Antigen
Alternative Name Interleukin-2 / IL2 (IL2 Antibody Abstract)
Background Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.Synonyms: IL-2, T-cell growth factor, TCGF
Gene ID 3558
NCBI Accession NP_000577
UniProt P60568
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL2 Antibody Target Details IL2 Handling References for anti-IL2 Antibody (ABIN1107821) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL2 Antibody Target Details IL2 Application Details References for anti-IL2 Antibody (ABIN1107821) Images back to top
Concentration 1.0 mg/mL
Buffer PBS without Carrier and preservatives. This product is Sterile-filtered through 0.22 μm and treated to remove endotoxins.
Preservative Without preservative
Handling Advice DO NOT FREEZE!
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8 °C.

References for anti-IL2 Antibody (ABIN1107821)

Product Details anti-IL2 Antibody Target Details IL2 Application Details Handling Images back to top
Background publications

Koopman, Mortier, Hofman, Mathy, Koutsoukos, Ertl, Overend, van Wely, Thomsen, Wahren, Voss, Heeney: "Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian-human immunodeficiency virus viraemia with protein/DNA combination." in: The Journal of general virology, Vol. 89, Issue Pt 2, pp. 540-53, 2008

Kobari, Giarratana, Gluckman, Douay, Rosenzwajg: "Ex vivo expansion does not alter the capacity of umbilical cord blood CD34+ cells to generate functional T lymphocytes and dendritic cells." in: Stem cells (Dayton, Ohio), Vol. 24, Issue 9, pp. 2150-7, 2006

Van Rhijn, Van den Berg, Ang, Admiraal, Logtenberg: "Expansion of human gammadelta T cells after in vitro stimulation with Campylobacter jejuni." in: International immunology, Vol. 15, Issue 3, pp. 373-82, 2003

Frétier, Besse, Delwail, Garcia, Morel, Leprivey-Lorgeot, Wijdenes, Praloran, Lecron: "Cyclosporin A inhibition of macrophage colony-stimulating factor (M-CSF) production by activated human T lymphocytes." in: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 289-94, 2002

Muñoz, van Seventer, Semnani, Leff: "Augmentation of LTC(4) synthesis in human eosinophils caused by CD3-stimulated Th2-like cells in vitro." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 278, Issue 6, pp. L1172-9, 2000

Groux, Bigler, de Vries, Roncarolo: "Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3188-93, 1998

Peng, Remacle, Kasran, Huylebroeck, Ceuppens: "IL-12 up-regulates CD40 ligand (CD154) expression on human T cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 3, pp. 1166-72, 1998

Fisfalen, Palmer, Van Seventer, Soltani, Sawai, Kaplan, Hidaka, Ober, DeGroot: "Thyrotropin-receptor and thyroid peroxidase-specific T cell clones and their cytokine profile in autoimmune thyroid disease." in: The Journal of clinical endocrinology and metabolism, Vol. 82, Issue 11, pp. 3655-63, 1997

Palmer, van Seventer: "Human T helper cell differentiation is regulated by the combined action of cytokines and accessory cell-dependent costimulatory signals." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 158, Issue 6, pp. 2654-62, 1997

Pilson, Levin, Desai, Reik, Lin, Korkmaz-Duffy, Campbell, Tso, Kerwin, Hakimi: "Bispecific humanized anti-IL-2 receptor alpha beta antibodies inhibitory for both IL-2- and IL-15-mediated proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 3, pp. 1543-56, 1997

Tortorella, Schulze-Koops, Thomas, Splawski, Davis, Picker, Lipsky: "Expression of CD45RB and CD27 identifies subsets of CD4+ memory T cells with different capacities to induce B cell differentiation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 155, Issue 1, pp. 149-62, 1995

Kuiper, de Jong, Brouwer, Lammers, Wijdenes, van Lier: "Influence of CD28 co-stimulation on cytokine production is mainly regulated via interleukin-2." in: Immunology, Vol. 83, Issue 1, pp. 38-44, 1995

Picker, Singh, Zdraveski, Treer, Waldrop, Bergstresser, Maino: "Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry." in: Blood, Vol. 86, Issue 4, pp. 1408-19, 1995

de Jong, Brouwer, Kuiper, Hooibrink, Miedema, van Lier: "Maturation- and differentiation-dependent responsiveness of human CD4+ T helper subsets." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 8, pp. 2795-802, 1992