We are preparing the requested document. Please wait, this may take a while...!
|Application / Reactivity||Mouse (Murine)||Chemical|
|Western Blotting (WB)||47 Antibodies||2 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Mass Cytometry (CyTOF)||2 Antibodies||2 Antibodies|
|Intracellular Flow Cytometry (ICFC)||2 Antibodies|
|Immunoprecipitation (IP)||50 Antibodies||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Immunohistochemistry (IHC)||17 Antibodies||5 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunofluorescence (IF)||8 Antibodies||2 Antibodies|
|Immunocytochemistry (ICC)||3 Antibodies||2 Antibodies|
|Functional Studies (Func)||6 Antibodies|
|Flow Cytometry (FACS)||123 Antibodies|
|Antigen||Interleukin 2 Receptor, beta (IL2RB) Antibodies|
|Reactivity||Chemical, Mouse (Murine) Alternatives|
|Conjugate||This IL2 Receptor beta antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|4 references available|
|Supplier||Log in to see|
Product Details anti-IL2 Receptor beta AntibodyTarget Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662986) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details IL2 Receptor betaProduct Details anti-IL2 Receptor beta Antibody Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662986) Images back to top
|Alternative Name||CD122 (IL2RB Antibody Abstract)|
|Background||CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit(CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The 5H4 antibody does not block IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Handling References for anti-IL2 Receptor beta Antibody (ABIN2662986) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details References for anti-IL2 Receptor beta Antibody (ABIN2662986) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL2 Receptor beta Antibody (ABIN2662986)Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling Images back to top
Minami, Kono, Miyazaki et al.: "The IL-2 receptor complex: its structure, function, and target genes." in: Annual review of immunology, Vol. 11, pp. 245-68, 1993 (PubMed).
Furse, Malek et al.: "Selection of internalization-deficient cells by interleukin-2-Pseudomonas exotoxin chimeric protein: the cytoplasmic domain of the interleukin-2 receptor beta chain does not contribute to ..." in: European journal of immunology, Vol. 23, Issue 12, pp. 3181-8, 1994 (PubMed).
Suzuki, Kündig, Furlonger et al.: "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta." in: Science (New York, N.Y.), Vol. 268, Issue 5216, pp. 1472-6, 1995 (PubMed).
He, Adkins, Furse et al.: "Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 4, pp. 1596-605, 1995 (PubMed).
ImagesProduct Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662986) back to top