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anti-Mouse (Murine) IL2 Receptor beta antibody for Mass Cytometry

Recommended IL2 Receptor beta Antibody (supplied by: Log in to see )

Antigen
Interleukin 2 Receptor, beta (IL2RB) Antibodies
  • CD122
  • Il-2/15Rbeta
  • il-2rb
  • Il-2Rbeta
  • IL-15Rbeta
  • IL2RB
  • IL2RBC
  • IL15RB
  • IL15Rbeta
  • p70
  • P70-75
Reactivity
Chemical, Mouse (Murine)
214
146
93
28
6
1
Host
Rat
146
114
85
Clonality
Monoclonal
Conjugate
This IL2 Receptor beta antibody is conjugated to PE
38
33
23
11
8
7
5
4
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Flow Cytometry (FACS), Mass Cytometry (CyTOF)
225
93
54
46
29
22
14
12
9
7
5
3
3
2
2
1
1
1
1
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Catalog No. ABIN2662988
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008709465 ABIN2662989 FACS CyTOF PE Rat IgG2b kappa Log in to see TM-beta1 6

Top referenced anti-IL2 Receptor beta antibody for Mass Cytometry

Similar anti-IL2 Receptor beta Antibodies

Application / Reactivity Mouse (Murine) Chemical
Blocking Reagent (BR) 3 Antibodies 2 Antibodies
ELISA 28 Antibodies
Flow Cytometry (FACS) 151 Antibodies 29 Antibodies
Functional Studies (Func) 6 Antibodies
Immunocytochemistry (ICC) 3 Antibodies 2 Antibodies
Immunofluorescence (IF) 8 Antibodies 2 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 22 Antibodies
Immunohistochemistry (IHC) 17 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 10 Antibodies
Immunoprecipitation (IP) 53 Antibodies
Mass Cytometry (CyTOF) 2 Antibodies
Neutralization (Neut) 4 Antibodies
Western Blotting (WB) 47 Antibodies

General

Antigen Interleukin 2 Receptor, beta (IL2RB) Antibodies
Reactivity Chemical, Mouse (Murine)
(214), (146), (93), (28), (6), (1)
Host Rat
(146), (114), (85)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL2 Receptor beta antibody is conjugated to PE
(38), (33), (23), (11), (8), (7), (5), (4), (4), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Flow Cytometry (FACS), Mass Cytometry (CyTOF)
(225), (93), (54), (46), (29), (22), (14), (12), (9), (7), (5), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-IL2 Receptor beta Antibody

Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662988) Images
Purification The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Clone TM-beta1
Isotype IgG2b kappa

Target Details IL2 Receptor beta

Product Details anti-IL2 Receptor beta Antibody Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662988) Images back to top
Antigen
Alternative Name CD122 (IL2RB Antibody Abstract)
Target Type Chemical
Background CD122 is a 70-75 kD IL-2 receptor β chain also known as IL-2Rβ, which is also shared by the IL-15 receptor. It is constitutively expressed by NK cells and at lower levels by T cells, B cells, monocytes, and macrophages. The IL-2Rβ chain can combine with either the common γ subunit (γc, CD132) alone or with the γc subunit and the IL-2Rα subunit(CD25) to generate intermediate or high affinity IL-2 receptor complexes, respectively. CD122 expression levels can be upregulated by activation. The TM-β1 antibody does inhibit IL-2 binding to the IL-2 receptor. CD122 is expressed on murine, but not human, CD8+ Tregs involved in the maintenance of T cell homeostasis.
Research Area CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Handling References for anti-IL2 Receptor beta Antibody (ABIN2662988) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details References for anti-IL2 Receptor beta Antibody (ABIN2662988) Images back to top
Concentration 0.2 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL2 Receptor beta Antibody (ABIN2662988)

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling Images back to top
Background publications

Hu, Zhang, Usherwood: "Regulatory CD8+ T cells associated with erosion of immune surveillance in persistent virus infection suppress in vitro and have a reversible proliferative defect." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 191, Issue 1, pp. 312-22, 2013

Suzuki, Kündig, Furlonger, Wakeham, Timms, Matsuyama, Schmits, Simard, Ohashi, Griesser: "Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta." in: Science (New York, N.Y.), Vol. 268, Issue 5216, pp. 1472-6, 1995

Minami, Kono, Miyazaki, Taniguchi: "The IL-2 receptor complex: its structure, function, and target genes." in: Annual review of immunology, Vol. 11, pp. 245-68, 1993

Tanaka, Kitamura, Nagasaka, Kuida, Suwa, Miyasaka: "Selective long-term elimination of natural killer cells in vivo by an anti-interleukin 2 receptor beta chain monoclonal antibody in mice." in: The Journal of experimental medicine, Vol. 178, Issue 3, pp. 1103-7, 1993

Tanaka, Takeuchi, Shiohara, Kitamura, Nagasaka, Hamamura, Yagita, Miyasaka: "In utero treatment with monoclonal antibody to IL-2 receptor beta-chain completely abrogates development of Thy-1+ dendritic epidermal cells." in: International immunology, Vol. 4, Issue 4, pp. 487-91, 1992

Tanaka, Tsudo, Karasuyama, Kitamura, Kono, Hatakeyama, Taniguchi, Miyasaka: "A novel monoclonal antibody against murine IL-2 receptor beta-chain. Characterization of receptor expression in normal lymphoid cells and EL-4 cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 7, pp. 2222-8, 1991

Images

Product Details anti-IL2 Receptor beta Antibody Target Details IL2 Receptor beta Application Details Handling References for anti-IL2 Receptor beta Antibody (ABIN2662988) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL2 Receptor beta antibody (Interleukin 2 Receptor, beta)  (PE) (ABIN2662988) anti-Interleukin 2 Receptor, beta (IL2RB) antibody (PE)