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|Application / Reactivity||Human||Mouse (Murine)|
|Western Blotting (WB)||95 Antibodies||33 Antibodies|
|Proximity Ligation Assay (PLA)||1 Antibodies|
|Neutralization (Neut)||7 Antibodies||1 Antibodies|
|Intracellular Staining (ICS)||2 Antibodies||5 Antibodies|
|Intracellular Flow Cytometry (ICFC)||3 Antibodies||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||5 Antibodies||12 Antibodies|
|Immunohistochemistry (IHC)||4 Antibodies||14 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies||2 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||2 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies||11 Antibodies|
|Immunofluorescence (IF)||6 Antibodies|
|Antigen||Interleukin 21 (IL21) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This IL21 antibody is conjugated to Biotin Alternatives|
Intracellular Flow Cytometry (ICFC)
|4 references available|
|Supplier||Log in to see|
Product Details anti-IL21 AntibodyTarget Details IL21 Application Details Handling References for anti-IL21 Antibody (ABIN2666224) Images
|Cross-Reactivity (Details)||Mouse* - weak affinity|
|Purification||The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.|
Target Details IL21Product Details anti-IL21 Antibody Application Details Handling References for anti-IL21 Antibody (ABIN2666224) Images back to top
|Alternative Name||IL-21 (IL21 Antibody Abstract)|
|Background||Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.|
|Research Area||Cytokines, Immunology, Virology, Inflammation, Cancer|
Application DetailsProduct Details anti-IL21 Antibody Target Details IL21 Handling References for anti-IL21 Antibody (ABIN2666224) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL21 Antibody Target Details IL21 Application Details References for anti-IL21 Antibody (ABIN2666224) Images back to top
|Buffer||phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||Upon receipt, store frozen between 2°C and 8°C.|
References for anti-IL21 Antibody (ABIN2666224)Product Details anti-IL21 Antibody Target Details IL21 Application Details Handling Images back to top
Parrish-Novak, Foster, Holly et al.: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002 (PubMed).
Asao, Okuyama, Kumaki et al.: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001 (PubMed).
Parrish-Novak, Dillon, Nelson et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000 (PubMed).
Dumoutier, Van Roost, Colau et al.: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000 (PubMed).
ImagesProduct Details anti-IL21 Antibody Target Details IL21 Application Details Handling References for anti-IL21 Antibody (ABIN2666224) back to top