anti-Mouse (Murine) IL21 antibody for Biochemical Assay

Recommended IL21 Antibody (supplied by: Log in to see )

Antigen
Interleukin 21 (IL21) Antibodies
  • IL-21
  • Za11
  • interleukin 21
  • interleukin 21-like
  • IL21
  • Il21
  • LOC100344172
Reactivity
Human, Mouse (Murine)
202
115
24
10
5
5
4
1
1
Host
Mouse
165
69
54
11
5
Clonality
Monoclonal
Conjugate
This IL21 antibody is un-conjugated
20
17
11
10
10
10
8
6
6
6
5
5
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
Application
Biochemical Assay (BCA)
187
132
62
39
34
26
15
13
6
6
5
4
4
3
3
3
2
1
1
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Catalog No. ABIN2666226
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General

Antigen Interleukin 21 (IL21) Antibodies
Reactivity Human, Mouse (Murine)
(202), (115), (24), (10), (5), (5), (4), (1), (1)
Host Mouse
(165), (69), (54), (11), (5)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL21 antibody is un-conjugated
(20), (17), (11), (10), (10), (10), (8), (6), (6), (6), (5), (5), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (1), (1), (1), (1), (1), (1)
Application Biochemical Assay (BCA)
(187), (132), (62), (39), (34), (26), (15), (13), (6), (6), (5), (4), (4), (3), (3), (3), (2), (1), (1)
Pubmed 4 references available
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Product Details anti-IL21 Antibody

Target Details IL21 Application Details Handling References for anti-IL21 antibody (ABIN2666226) Images
Cross-Reactivity (Details) Mouse* - weak affinity
Purification The antibody was purified by affinity chromatography.
Clone 7H20-I19-M3
Isotype IgG1 kappa

Target Details IL21

Product Details anti-IL21 Antibody Application Details Handling References for anti-IL21 antibody (ABIN2666226) Images back to top
Antigen
Alternative Name IL-21 (IL21 Antibody Abstract)
Background Interleukin 21 (IL-21) is a potent immunomodulatory cytokine mainly produced by NKT and CD4+ T-cells, particularly the inflammatory Th17 subset and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhancing proliferation of NK cells and cytotoxic T cells, and inhibitory effects on the antigen-presenting function of dendritic cells. It can also be proapoptotic for B cells and NK cells. Recent studies have shown that IL-21 is also an autocrine cytokine that potently induces T(H)17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Research Area Cytokines, Immunology, Virology, Inflammation, Cancer
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response

Application Details

Product Details anti-IL21 Antibody Target Details IL21 Handling References for anti-IL21 antibody (ABIN2666226) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL21 Antibody Target Details IL21 Application Details References for anti-IL21 antibody (ABIN2666226) Images back to top
Concentration 0.5 mg/mL
Buffer phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide. Final antibody concentration is 0.5 mg/mL.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Upon receipt, store frozen between 2°C and 8°C.

References for anti-IL21 antibody (ABIN2666226)

Product Details anti-IL21 Antibody Target Details IL21 Application Details Handling Images back to top
Background publications

Parrish-Novak, Foster, Holly, Clegg: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Dumoutier, Van Roost, Colau, Renauld: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000

Parrish-Novak, Dillon, Nelson, Hammond, Sprecher, Gross, Johnston, Madden, Xu, West, Schrader, Burkhead, Heipel, Brandt, Kuijper, Kramer, Conklin, Presnell, Berry, Shiota, Bort, Hambly, Mudri, Clegg et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000

Images

Product Details anti-IL21 Antibody Target Details IL21 Application Details Handling References for anti-IL21 antibody (ABIN2666226) back to top
Supplier Images
Western Blotting (WB) image for anti-Interleukin 21 (IL21) antibody (ABIN2666226) anti-Interleukin 21 (IL21) antibody