A novel cytokine related to IL2 and IL15 was recently identified and designated IL21.IL21 has been found to be a powerful growth factor for naive B cells. The receptor forIL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of theclass I cytokine receptor family. IL21R forms a complex with the common cytokinereceptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessaryfor the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21Ris expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role inthe proliferation and maturation of NK, B and T cell populations. Alternate Names: anti-IL 21 antibody, anti-IL21 antibody, anti-Interleukin 21 antibody, anti-Interleukin21antibody, anti-Za11 antibody. Gene Symbol: IL21
140 mM Sodium chloride, 140 mM Potassium Phosphate [pH 7], Sodium Azide
Precaution of Use
WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Avoid freeze-thaw cycles
4 °C short term. Aliquot and store at -20 °C long term.