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anti-Human IL21 Receptor antibody for ELISA

Recommended IL21 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin 21 Receptor (IL21R) Antibodies
  • IL21R
  • il-21ra.a
  • CD360
  • NILR
  • interleukin 21 receptor
  • IL21R
  • il21r
  • Il21r
Reactivity
Human
100
56
33
2
Host
Mouse
77
24
16
8
Clonality
Monoclonal
Conjugate
This IL21 Receptor antibody is un-conjugated
11
6
5
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA
57
38
35
23
13
13
4
4
4
3
2
2
1
1
Supplier
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Catalog No. ABIN2665682
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2658204 IP ELISA WB APC Mouse IgG1 kappa Log in to see 17A12 10
1 ABIN208550 ELISA WB Rabbit IgG AA 65-80 Log in to see Polyclonal
1 ABIN1002623 IHC ELISA WB Rabbit IgG Extracellular Domain Log in to see Polyclonal 4
1 ABIN2487948 IHC (fp) ELISA Goat IgG AA 35-65, N-Term Log in to see Polyclonal
1 ABIN1002624 ELISA WB Rabbit IgG N-Term Log in to see Polyclonal 4
1 ABIN4324918 ELISA ICC IF IHC IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN4324917 ELISA ICC IF WB Rabbit Log in to see Polyclonal
1 ABIN1819422 IHC (p) ELISA Goat IgG AA 35-65 Log in to see Polyclonal
1 ABIN2665681 FACS IF IHC ELISA Mouse IgG1 kappa Log in to see 17A12 10
1 ABIN2658205 IP ELISA WB APC Mouse IgG1 kappa Log in to see 17A12 10
1 ABIN342773 IHC ELISA Goat N-Term Log in to see Polyclonal
1 ABIN1998791 ELISA Rabbit IgG AA 1-236 Log in to see 33
1 ABIN1087629 IHC ELISA WB Rabbit IgG Log in to see Polyclonal
1 ABIN1087630 IHC ELISA WB Rabbit IgG Log in to see Polyclonal
1 ABIN2421119 IHC ELISA Rabbit IgG Log in to see Polyclonal
1 ABIN2427703 IHC ELISA Rabbit IgG Log in to see Polyclonal
1 ABIN1886852 ELISA WB Rabbit AA 20-32 Log in to see Polyclonal
1 ABIN1886904 IHC ELISA WB Rabbit AA 97-111 Log in to see Polyclonal
1 ABIN1998793 ELISA Rabbit IgG AA 1-236 Log in to see Polyclonal
1 ABIN2288650 IHC ELISA Goat IgG N-Term Log in to see Polyclonal

Top referenced anti-IL21 Receptor antibody for ELISA

Similar anti-IL21 Receptor Antibodies

Application / Reactivity Human
Biochemical Assay (BCA) 4 Antibodies
ELISA 31 Antibodies
Enzyme Immunoassay (EIA) 2 Antibodies
Flow Cytometry (FACS) 19 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 4 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 13 Antibodies
Immunohistochemistry (IHC) 19 Antibodies
Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 12 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Mass Cytometry (CyTOF) 1 Antibodies
Western Blotting (WB) 54 Antibodies

General

Antigen Interleukin 21 Receptor (IL21R) Antibodies
Reactivity Human
(100), (56), (33), (2)
Host Mouse
(77), (24), (16), (8)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL21 Receptor antibody is un-conjugated
(11), (6), (5), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA
(57), (38), (35), (23), (13), (13), (4), (4), (4), (3), (2), (2), (1), (1)
Pubmed 10 references available
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Product Details anti-IL21 Receptor Antibody

Target Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2665682) Images
Brand LEAF™
Purification The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level

Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.

Clone 17A12
Isotype IgG1 kappa

Target Details IL21 Receptor

Product Details anti-IL21 Receptor Antibody Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2665682) Images back to top
Antigen
Alternative Name CD360 (IL21R Antibody Abstract)
Background Human interleukin 21 receptor (IL-21R) is a single pass type I membrane protein and a member of the type I cytokine receptor family. Of the type I cytokine receptors, IL-21R exhibits greatest extracellular homology to the IL-2R beta subunit (i.e., it contains one copy of the WSXWS-containing cytokine-binding domain). Intracellular domains of IL-21R include the Box 1 and Box 2 elements, which are similar to the IL-9R intracellular region. Upon binding IL-21, IL-21R forms a heterodimer with the common gamma subunit (CD132) and induces Jak/Stat signaling. IL-21R is expressed on B cells and at various levels on NK and T cells. IL-21 is a potent immunomodulatory cytokine mainly produced by NKT and CD4 T-cells (particularly the inflammatory Th17 subset) and has pleiotropic effects on both innate and adaptive immune responses. These actions include positive effects such as enhanced proliferation of natural killer (NK) cells and cytotoxic T cells that can destroy virally infected or cancerous cells and direct inhibitory effects on the antigen-presenting function of dendritic cells, and can be proapoptotic for B cells and NK cells. Studies have shown that IL-21 is also an autocrine cytokine that potently induces Th17 differentiation and suppresses Foxp3 expression, and serves as a target for treating inflammatory diseases.
Pathways JAK-STAT Signaling

Application Details

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Handling References for anti-IL21 Receptor Antibody (ABIN2665682) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details References for anti-IL21 Receptor Antibody (ABIN2665682) Images back to top
Concentration 1.0 mg/mL
Preservative Azide free
Handling Advice This LEAF™ solution contains no preservative, handle under aseptic conditions
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL21 Receptor Antibody (ABIN2665682)

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling Images back to top
Background publications

Bannantine, Stabel, Lamont, Briggs, Sreevatsan: "Monoclonal Antibodies Bind A SNP-Sensitive Epitope that is Present Uniquely in Mycobacterium avium Subspecies Paratuberculosis." in: Frontiers in microbiology, Vol. 2, pp. 163, 2011

Spolski, Leonard: "Interleukin-21: basic biology and implications for cancer and autoimmunity." in: Annual review of immunology, Vol. 26, pp. 57-79, 2008

Davis, Skak, Smyth, Kristjansen, Miller, Sivakumar: "Interleukin-21 signaling: functions in cancer and autoimmunity." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 13, Issue 23, pp. 6926-32, 2007

Nurieva, Yang, Martinez, Zhang, Panopoulos, Ma, Schluns, Tian, Watowich, Jetten, Dong: "Essential autocrine regulation by IL-21 in the generation of inflammatory T cells." in: Nature, Vol. 448, Issue 7152, pp. 480-3, 2007

de Totero, Meazza, Zupo, Cutrona, Matis, Colombo, Balleari, Pierri, Fabbi, Capaia, Azzarone, Gobbi, Ferrarini, Ferrini: "Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells." in: Blood, Vol. 107, Issue 9, pp. 3708-15, 2006

Parrish-Novak, Foster, Holly, Clegg: "Interleukin-21 and the IL-21 receptor: novel effectors of NK and T cell responses." in: Journal of leukocyte biology, Vol. 72, Issue 5, pp. 856-63, 2002

Asao, Okuyama, Kumaki, Ishii, Tsuchiya, Foster, Sugamura: "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 1, pp. 1-5, 2001

Dumoutier, Van Roost, Colau, Renauld: "Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 18, pp. 10144-9, 2000

Ozaki, Kikly, Michalovich, Young, Leonard: "Cloning of a type I cytokine receptor most related to the IL-2 receptor beta chain." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 21, pp. 11439-44, 2000

Parrish-Novak, Dillon, Nelson, Hammond, Sprecher, Gross, Johnston, Madden, Xu, West, Schrader, Burkhead, Heipel, Brandt, Kuijper, Kramer, Conklin, Presnell, Berry, Shiota, Bort, Hambly, Mudri, Clegg et al.: "Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. ..." in: Nature, Vol. 408, Issue 6808, pp. 57-63, 2000

Images

Product Details anti-IL21 Receptor Antibody Target Details IL21 Receptor Application Details Handling References for anti-IL21 Receptor Antibody (ABIN2665682) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-IL21 Receptor antibody (Interleukin 21 Receptor) (ABIN2665682) anti-Interleukin 21 Receptor (IL21R) antibody
Flow Cytometry (FACS) image for anti-IL21 Receptor antibody (Interleukin 21 Receptor) (ABIN2665682) anti-Interleukin 21 Receptor (IL21R) antibody (Image 2)