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anti-Human IL2R Antibodies:
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Among patients with a low pretreatment sIL (show PMEL Antibodies)-2R level who exhibited a positive response to R-CHOP (show DDIT3 Antibodies), the posttreatment sIL (show PMEL Antibodies)-2R level may help to identify those with a poor prognosis.
The findings not only confirm the predictive power of CD25 (show IL2RA Antibodies) expression for Philadelphia chromosome translocation (Ph)+ but also demonstrate that CD25 (show IL2RA Antibodies) expression is associated with RD (a biomarker correlated with prognosis) in Ph- patients. The latter finding is likely associated with underlying molecular abnormalities, including Ph-like genotype.
Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA (show IL2RA Antibodies) in men.
it has been shown that CD25 (show IL2RA Antibodies) serves as a negative growth regulator of Chronic myeloid leukemia (show BCL11A Antibodies) leukemic stem cells.
study provides evidence that membrane-coated microvesicles released by apoptotic neutrophils suppress a subset of resting Th cells by downregulating IL-2 (show IL2 Antibodies) and IL-2R expression
In T1D, low IL-2 (show IL2 Antibodies) responsiveness was most pronounced in memory T effector cells. Reduced IL-2 (show IL2 Antibodies) responses in memory T effector cells were not rescued by resting, remained lower after activation and proliferation, and were absent in type 2 diabetes.
Decidual stromal cells affect IL-2 (show IL2 Antibodies) production and IL-2R expression and signaling.
The single nucleotide variant rs12722489 determines differential ERalpha (show ESR1 Antibodies) binding and enhancer properties of an IL2RA (show IL2RA Antibodies) intronic region.
CDK6 (show CDK6 Antibodies)-mediated suppression of CD25 (show IL2RA Antibodies) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Antibodies)
CD4 (show CD4 Antibodies)(+) CD25 (show IL2RA Antibodies)(+) GARP (show CNGB1 Antibodies)(+) Treg cells are defective in dilated cardiomyopathy patients and GARP (show CNGB1 Antibodies) seems to be a better molecular definition of the regulatory phenotype.
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha