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The study demonstrated Increased level of CD25 (show IL2RA Proteins) in patients with active vitilligo.
CD45RA distinguishes CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127 (show IL7R Proteins)-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression.
Combination with anti-programmed cell death protein-1 (PD-1 (show PDCD1 Proteins)) antibodies promoted complete tumor rejection (show SUPT20H Proteins), indicating the relevance of CD25 antigen (show IL2RA Proteins) as a therapeutic target and promising substrate for future combination approaches in immune-oncology.
A compensatory mechanism of IL-7 (show IL7 Proteins)-mediated homeostatic proliferation can restore the inhibitory network of CD24 (show CD24 Proteins)+Foxp3 (show FOXP3 Proteins)+Treg cell after anti-CD25 (show IL2RA Proteins) induction therapy in islet allotransplantation.
(99) Tc-methylene diphosphonate may improve the activity of RA through upregulating the frequency of peripheral gammadelta T cells and CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) Foxp3 (show FOXP3 Proteins)(+) Tregs as well as affecting the serum cytokine environment by increasing TGF-beta (show TGFB1 Proteins) and decreasing TNF-alpha (show TNF Proteins) and IL-6 (show IL6 Proteins).
IL-2Ra (show IL2RA Proteins) Interleukin-2 (show IL2 Proteins) receptor antagonists (IL-2Ra (show IL2RA Proteins)) reduces the risk on new-onset diabetes after transplantation (NODAT) in liver transplant recipients.
The percentages of CD8 (show CD8A Proteins)(+)CD25 (show IL2RA Proteins)(+)FoxP3 (show FOXP3 Proteins)(brigh) Tregs correlate with mean peak expiratory flow.
Efficiently downregulated the percentages of CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+Foxp3 (show FOXP3 Proteins)+ regulator T (Treg) cells.
introduce the combined use of CD25 (show IL2RA Proteins) and properly strati fi ed CD135 (show FLT3 Proteins) values as alternatives to testing for the FLT3 (show FLT3 Proteins)-ITD mutation
this study shows that PTPN22 (show PTPN22 Proteins) genetic polymorphisms play role in predisposition of type 1 diabetes mellitus in Egyptian children
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha