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IL-2R Proteins (CD132)
On are 1 IL-2R (CD132) Proteins from 1 different suppliers available. Additionally we are shipping IL2R Kits (3) and IL2R Antibodies (1) and many more products for this protein. A total of 5 IL2R products are currently listed.
list all proteins Gene Name GeneID UniProt
CD132 3559 P01589

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Human IL-2R (CD132) interaction partners

  1. Through GWAS, we found that emotion dysregulation is associated at genome-wide level significance in a sex-specific manner, with a SNP in IL2RA (show IL2RA Proteins) in men.

  2. it has been shown that CD25 (show IL2RA Proteins) serves as a negative growth regulator of Chronic myeloid leukemia (show BCL11A Proteins) leukemic stem cells.

  3. study provides evidence that membrane-coated microvesicles released by apoptotic neutrophils suppress a subset of resting Th cells by downregulating IL-2 (show IL2 Proteins) and IL-2R expression

  4. In T1D, low IL-2 (show IL2 Proteins) responsiveness was most pronounced in memory T effector cells. Reduced IL-2 (show IL2 Proteins) responses in memory T effector cells were not rescued by resting, remained lower after activation and proliferation, and were absent in type 2 diabetes.

  5. Decidual stromal cells affect IL-2 (show IL2 Proteins) production and IL-2R expression and signaling.

  6. The single nucleotide variant rs12722489 determines differential ERalpha (show ESR1 Proteins) binding and enhancer properties of an IL2RA (show IL2RA Proteins) intronic region.

  7. CDK6 (show CDK6 Proteins)-mediated suppression of CD25 (show IL2RA Proteins) is required for initiation of T-ALL by activated Notch1 (show NOTCH1 Proteins)

  8. CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) GARP (show CNGB1 Proteins)(+) Treg cells are defective in dilated cardiomyopathy patients and GARP (show CNGB1 Proteins) seems to be a better molecular definition of the regulatory phenotype.

  9. Studies indicate many potential uses of soluble interleukin-2 (show IL2 Proteins) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.

  10. Data suggest that differential methylation of the IL2RA (show IL2RA Proteins) promoter in T cells could be an important pathogenic mechanism in multiple sclerosis.

IL2R (CD132) Protein Profile

Protein Summary

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.

Alternative names and synonyms associated with IL2R (CD132)

  • interleukin 2 receptor, alpha (IL2RA)
  • CD25 protein
  • IDDM10 protein
  • IL2R protein
  • TCGFR protein

Protein level used designations for IL-2R Proteins (CD132)

IL-2 receptor subunit alpha , IL-2-RA , IL-2R subunit alpha , IL2-RA , TAC antigen , interleukin-2 receptor subunit alpha , p55

3559 Homo sapiens
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