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CD45RA distinguishes CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127 (show IL7R Proteins)-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression.
Combination with anti-programmed cell death protein-1 (PD-1 (show PDCD1 Proteins)) antibodies promoted complete tumor rejection (show SUPT20H Proteins), indicating the relevance of CD25 antigen (show IL2RA Proteins) as a therapeutic target and promising substrate for future combination approaches in immune-oncology.
A compensatory mechanism of IL-7 (show IL7 Proteins)-mediated homeostatic proliferation can restore the inhibitory network of CD24 (show CD24 Proteins)+Foxp3 (show FOXP3 Proteins)+Treg cell after anti-CD25 (show IL2RA Proteins) induction therapy in islet allotransplantation.
(99) Tc-methylene diphosphonate may improve the activity of RA through upregulating the frequency of peripheral gammadelta T cells and CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) Foxp3 (show FOXP3 Proteins)(+) Tregs as well as affecting the serum cytokine environment by increasing TGF-beta (show TGFB1 Proteins) and decreasing TNF-alpha (show TNF Proteins) and IL-6 (show IL6 Proteins).
IL-2Ra (show IL2RA Proteins) Interleukin-2 (show IL2 Proteins) receptor antagonists (IL-2Ra (show IL2RA Proteins)) reduces the risk on new-onset diabetes after transplantation (NODAT) in liver transplant recipients.
The percentages of CD8 (show CD8A Proteins)(+)CD25 (show IL2RA Proteins)(+)FoxP3 (show FOXP3 Proteins)(brigh) Tregs correlate with mean peak expiratory flow.
Efficiently downregulated the percentages of CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+Foxp3 (show FOXP3 Proteins)+ regulator T (Treg) cells.
introduce the combined use of CD25 (show IL2RA Proteins) and properly strati fi ed CD135 (show FLT3 Proteins) values as alternatives to testing for the FLT3 (show FLT3 Proteins)-ITD mutation
this study shows that PTPN22 (show PTPN22 Proteins) genetic polymorphisms play role in predisposition of type 1 diabetes mellitus in Egyptian children
dissected the first intron of the IL2RA (show IL2RA Proteins) gene and selected several single nucleotide polymorphisms (SNPs) that may influence the regulation of the IL2RA (show IL2RA Proteins) gene in cell types relevant to autoimmune pathology
The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
IL-2 receptor subunit alpha
, IL-2R subunit alpha
, TAC antigen
, interleukin-2 receptor subunit alpha