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|Application / Reactivity||Mouse (Murine)|
|Blocking Reagent (BR)||1 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||13 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||4 Antibodies|
|Intracellular Flow Cytometry (ICFC)||1 Antibodies|
|Neutralization (Neut)||3 Antibodies|
|Western Blotting (WB)||14 Antibodies|
|Antigen||Interleukin 2 Receptor, gamma (IL2RG) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This IL2RG antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|9 references available|
|Supplier||Log in to see|
Product Details anti-IL2RG AntibodyTarget Details IL2RG Application Details Handling References for anti-IL2RG Antibody (ABIN2663006) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details IL2RGProduct Details anti-IL2RG Antibody Application Details Handling References for anti-IL2RG Antibody (ABIN2663006) Images back to top
|Alternative Name||CD132 (IL2RG Antibody Abstract)|
|Background||CD132 is a 64-70 kD type I transmembrane glycoprotein of the Ig superfamily, and is also known as common γ chain (γc) or IL-2 receptor γ subunit. It is expressed broadly on T- and B-lymphocytes, NK cells, monocytes, and granulocytes. CD132 is an essential component of cytokine receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Ligand binding induces tyrosine phosphorylation and initiates signaling through a JAK/STAT pathway. CD132 mutation results in X-linked severe combined immune deficiency (XSCID).|
Application DetailsProduct Details anti-IL2RG Antibody Target Details IL2RG Handling References for anti-IL2RG Antibody (ABIN2663006) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details References for anti-IL2RG Antibody (ABIN2663006) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL2RG Antibody (ABIN2663006)Product Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling Images back to top
Hennion-Tscheltzoff, Leboeuf, Gauthier et al.: "TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy." in: Blood, Vol. 121, Issue 23, pp. 4684-93, 2013 (PubMed).
Veerman, Carlow, Shanina et al.: "PSGL-1 regulates the migration and proliferation of CD8(+) T cells under homeostatic conditions." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 188, Issue 4, pp. 1638-46, 2012 (PubMed).
Habib, Senadheera, Weinberg et al.: "The common gamma chain (gamma c) is a required signaling component of the IL-21 receptor and supports IL-21-induced cell proliferation via JAK3." in: Biochemistry, Vol. 41, Issue 27, pp. 8725-31, 2002 (PubMed).
Itano, Tsuchiya, Morita et al.: "IL-2 receptor gamma chain expression on CD34 positive hematopoietic progenitor cells from bone marrow and cord blood." in: The Tohoku journal of experimental medicine, Vol. 178, Issue 4, pp. 389-98, 1996 (PubMed).
Kondo, Takeshita, Higuchi et al.: "Functional participation of the IL-2 receptor gamma chain in IL-7 receptor complexes." in: Science (New York, N.Y.), Vol. 263, Issue 5152, pp. 1453-4, 1994 (PubMed).
Nakarai, Robertson, Streuli et al.: "Interleukin 2 receptor gamma chain expression on resting and activated lymphoid cells." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 241-51, 1994 (PubMed).
Matthews, Clark, Herbert et al.: "Function of the interleukin-2 (IL-2) receptor gamma-chain in biologic responses of X-linked severe combined immunodeficient B cells to IL-2, IL-4, IL-13, and IL-15." in: Blood, Vol. 85, Issue 1, pp. 38-42, 1995 (PubMed).
Kimura, Takeshita, Kondo et al.: "Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex." in: International immunology, Vol. 7, Issue 1, pp. 115-20, 1995 (PubMed).
Kawahara, Minami, Miyazaki et al.: "Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 19, pp. 8724-8, 1995 (PubMed).
ImagesProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details Handling References for anti-IL2RG Antibody (ABIN2663006) back to top