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|Antigen||Interleukin 2 Receptor, gamma (IL2RG) Antibodies|
|Epitope||AA 1-262 Alternatives|
|Reactivity||Rat (Rattus) Alternatives|
|Conjugate||This IL2RG antibody is un-conjugated Alternatives|
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Product Details anti-IL2RG AntibodyTarget Details IL2RG Application Details Handling Images
|Specificity||Rat IL2RG / CD132|
|Characteristics||Produced in rabbits immunized with purified, recombinant Rat IL2RG / CD132 (rR IL2RG / CD132, ABIN2009291 Q68FU6, Met1-Ala262,. Total IgG was purified by Protein A affinity chromatography.|
|Purification||purified by Protein A affinity chromatography|
|Sterility||0.2 μm filtered|
|Immunogen||Recombinant Rat IL2RG / CD132 protein (ABIN2009291)|
Target Details IL2RGProduct Details anti-IL2RG Antibody Application Details Handling Images back to top
|Alternative Name||IL2RG (IL2RG Antibody Abstract)|
|Background||The interleukin 2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, which binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as α, β and γ, which are non-covalently associated are identified. The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ chain, along with the β subunit which are members of the type I cytokine receptor family. The α chain of the IL-2R can bind to the β chain before receptor interaction with IL-2. The γ chain alone has a very weak affinity for IL- 2, but after the ligand is bound to the α/β heterodimer, the γ chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. It is proposed that the γ chain is common to the IL2, IL4, IL7, IL21 and probably also the IL13 receptors.|
|Pathways||JAK-STAT Signaling, Growth Factor Binding|
Application DetailsProduct Details anti-IL2RG Antibody Target Details IL2RG Handling Images back to top
ELISA: 0.5-1 μg/mL
This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Rat IL2RG / CD132. The detection limit for Rat IL2RG / CD132 is approximately ≤ 0.039 ng/well.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL2RG Antibody Target Details IL2RG Application Details Images back to top
|Buffer||0.2 μm filtered solution in PBS with 5 % trehalose|
|Handling Advice||Avoid repeated freeze-thaw cycles.|
|Storage||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
|Expiry Date||12 months|