Browse our IL2RG Proteins (IL2RG)

Full name:
Interleukin 2 Receptor, gamma Proteins (IL2RG)
On are 26 Interleukin 2 Receptor, gamma (IL2RG) Proteins from 10 different suppliers available. Additionally we are shipping IL2RG Antibodies (162) and IL2RG Kits (17) and many more products for this protein. A total of 218 IL2RG products are currently listed.
Ab2-183, CD132, CIDX, gamma(c), gc, IL-2RG, IMD4, P64, SCIDX, SCIDX1, [g]c
list all proteins Gene Name GeneID UniProt
IL2RG 140924  
IL2RG 3561 P31785
IL2RG 16186 P34902

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IL2RG Proteins (IL2RG) by Origin

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Top referenced IL2RG Proteins

  1. Human IL2RG Protein expressed in HEK-293 Cells - ABIN2181389 : Kondo, Takeshita, Ishii, Nakamura, Watanabe, Arai, Sugamura: Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. in Science (New York, N.Y.) 1994 (PubMed)
    Show all 3 references for 2181389

More Proteins for IL2RG Interaction Partners

Rhesus Monkey Interleukin 2 Receptor, gamma (IL2RG) interaction partners

  1. Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8 (show CD8A Proteins)(+) T cells, and, may be linked with immune failure and loss of viral containment.

Human Interleukin 2 Receptor, gamma (IL2RG) interaction partners

  1. systematic scoping review highlights the many potential uses of soluble interleukin-2 (show IL2 Proteins) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.

  2. analysis of the contribution of IL2Rgamma to the dynamic formation of IL2 (show IL2 Proteins)-IL2R (show IL2RA Proteins) complexes

  3. A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency (show PRKDC Proteins) with an atypical phenotype

  4. novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency (show PRKDC Proteins) with the presence of T cells and NK cells and revertant somatic mosaicism

  5. reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID (show PRKDC Proteins)

  6. High IL2RG expression is associated with Sezary syndrome.

  7. Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta (show IL2RB Proteins) to suppress IL-2 (show IL2 Proteins) signaling and to promote pro-inflammatory Th17 cell differentiation. [review]

  8. Study show the detection of IL2RG mutations in 2 families with X-SCID (show PRKDC Proteins) and identified 2 novel mutations, confirming the X-SCID (show PRKDC Proteins) pedigrees.

  9. Interleukin 2 receptor subunit gamma mutation is associated with X-linked severe combined immunodeficiency (show PRKDC Proteins).

  10. Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (show JAK3 Proteins)-mutation-positive leukemias.

Mouse (Murine) Interleukin 2 Receptor, gamma (IL2RG) interaction partners

  1. degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.

  2. We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2 (show RAG2 Proteins)-/-IL2Rgnull mice.

  3. Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (show JAK3 Proteins)-mutation-positive leukemias.

  4. findings demonstrate that NOD SCID (show PRKDC Proteins) IL2R (show IL2RA Proteins) common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID (show PRKDC Proteins) mice

  5. Interleukin-2 (show IL2 Proteins) signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.

  6. gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8 (show CD8A Proteins)+ cytotoxic lineage T cells and into invariant natural killer T cells.

  7. analysis of multiorgan metastasis of human HER-2 (show ERBB2 Proteins)+ breast cancer in Rag2 (show RAG2 Proteins)-/-;Il2rg-/- mice and treatment with PI3K inhibitor

  8. Results indicated that the extracellular and transmembrane domains of gammaC and IL-13Ralpha1 controlled the magnitude of the intracellular signaling response to IL-4 (show IL4 Proteins) and IL-13 (show IL13 Proteins).

  9. physiologic impact of CB hematopoietic progenitor cell hypofucosylation was investigated in vivo in NOD-SCID interleukin (IL)-2Rgamma(null) (NSG) mice

  10. CD34 (show CD34 Proteins)+ CD133+ hematopoietic stem cells cultured with growth factors including Angptl5 efficiently engraft adult NOD-SCID (show PRKDC Proteins) Il2rgamma-/- (NSG) mice

IL2RG Protein Profile

Protein Summary

The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.

Alternative names and synonyms associated with IL2RG

  • interleukin 2 receptor, gamma (IL2RG)
  • interleukin 2 receptor, gamma (il2rg)
  • interleukin 2 receptor, gamma (Il2rg)
  • interleukin 2 receptor, gamma chain (Il2rg)
  • Ab2-183 protein
  • CD132 protein
  • CIDX protein
  • gamma(c) protein
  • gc protein
  • IL-2RG protein
  • IMD4 protein
  • P64 protein
  • SCIDX protein
  • SCIDX1 protein
  • [g]c protein

Protein level used designations for IL2RG

cytokine receptor common subunit gamma , interleukin 2 receptor gamma , interleukin 2 receptor, gamma (severe combined immunodeficiency) , membrane receptor Il2rg , interleukin 2 receptor, gamma , CD132 antigen , IL-2 receptor subunit gamma , IL-2R subunit gamma , common cytokine receptor gamma chain , gammaC , IL-2R gamma chain , IL-2RG , cytokine receptor common gamma chain , gamma-C , interleukin-2 receptor gamma chain , interleukin-2 receptor subunit gamma , p64 , interleukin 2 receptor gamma chain , common gamma chain , gamma C receptor

397156 Sus scrofa
641338 Macaca mulatta
100036958 Xenopus laevis
100585758 Nomascus leucogenys
140924 Rattus norvegicus
3561 Homo sapiens
281862 Bos taurus
403851 Canis lupus familiaris
16186 Mus musculus
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