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Down-regulation of gamma(c) during early HIV/SIV infection may inhibit T-cell function, particularly of CD8 (show CD8A Proteins)(+) T cells, and, may be linked with immune failure and loss of viral containment.
New insights of common gamma chain in hematological malignancies.
this study shows that downregulation of miR (show MLXIP Proteins)-3940-5p promotes T-cell activity by targeting the cytokine receptor (show EBI3 Proteins) IL-2R gamma on human cutaneous T-cell lines
Characterization of interleukin receptor beta/gamma-associated protein complex assembly in IL-2 (show IL2 Proteins)- and IL-15 (show IL15 Proteins)-activated T-cells has been reported.
systematic scoping review highlights the many potential uses of soluble interleukin-2 (show IL2 Proteins) receptor measurement in the diagnosis and treatment of hemophagocytic syndromes.
analysis of the contribution of IL2Rgamma to the dynamic formation of IL2 (show IL2 Proteins)-IL2R (show IL2RA Proteins) complexes
A deletion mutation in IL2RG gene results in X-linked severe combined immunodeficiency (show PRKDC Proteins) with an atypical phenotype
novel missense mutation in Japanese patient results in atypical X-linked severe combined immunodeficiency (show PRKDC Proteins) with the presence of T cells and NK cells and revertant somatic mosaicism
reversion of mutation in common lymphoid progenitor results in mild phenotype of SCID (show PRKDC Proteins)
High IL2RG expression is associated with Sezary syndrome.
Identification of a gammaC splice isoform revealed expression of soluble gammaC proteins (sgammaC). sgammaC directly interacted with surface IL-2Rbeta (show IL2RB Proteins) to suppress IL-2 (show IL2 Proteins) signaling and to promote pro-inflammatory Th17 cell differentiation. [review]
Suggest that soluble common gamma chain may be one of the target molecules for the control of immunopathogenic progresses in COPD (show ARCN1 Proteins).
Results indicate that conjugated-interleukin-2 (IL2 (show IL2 Proteins)) protein derived from NKTR (show NKTR Proteins)-214 occupy interleukin-2 (IL2 (show IL2 Proteins)) receptor complex (IL2Ralphabetagamma) to a greater extent compared to free-IL2 (show IL2 Proteins) protein.
Renal lesions are indeed modulated by intrinsic glomerular cells through the gamma-C/IL-2 (show IL2 Proteins)-beta receptor response, to date classically described only in immune cells.
degree to which immune rejection contributes to these disappointing outcomes using an immunodeficient IL2 receptor gamma (IL2rgamma)-null mouse model, was examined.
We have confirmed the activation of human peripheral blood lymphocytes after being xenografted in immunodeficient Rag2 (show RAG2 Proteins)-/-IL2Rgnull mice.
Results demonstrate that IL2Rgamma has an onogenic role in JAK3 (show JAK3 Proteins)-mutation-positive leukemias.
findings demonstrate that NOD SCID (show PRKDC Proteins) IL2R (show IL2RA Proteins) common gamma chain -/- mice are capable of engraftment of canine PBLs yet develop graft versus host disease similar to Hu-PBL-SCID (show PRKDC Proteins) mice
Interleukin-2 (show IL2 Proteins) signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor.
gammac expression was required to signal the differentiation of MHC class I-specific thymocytes into CD8 (show CD8A Proteins)+ cytotoxic lineage T cells and into invariant natural killer T cells.
analysis of multiorgan metastasis of human HER-2 (show ERBB2 Proteins)+ breast cancer in Rag2 (show RAG2 Proteins)-/-;Il2rg-/- mice and treatment with PI3K inhibitor
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder.
cytokine receptor common subunit gamma
, interleukin 2 receptor gamma
, interleukin 2 receptor, gamma (severe combined immunodeficiency)
, membrane receptor Il2rg
, interleukin 2 receptor, gamma
, CD132 antigen
, IL-2 receptor subunit gamma
, IL-2R subunit gamma
, common cytokine receptor gamma chain
, IL-2R gamma chain
, cytokine receptor common gamma chain
, interleukin-2 receptor gamma chain
, interleukin-2 receptor subunit gamma
, interleukin 2 receptor gamma chain
, common gamma chain
, gamma C receptor