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|Application / Reactivity||Human|
|Blocking Reagent (BR)||3 Antibodies|
|Dot Blot (DB)||10 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies|
|Flow Cytometry (FACS)||102 Antibodies|
|Fluorescence Microscopy (FM)||1 Antibodies|
|Functional Studies (Func)||1 Antibodies|
|Immunochromatography (IC)||3 Antibodies|
|Immunocytochemistry (ICC)||12 Antibodies|
|Immunofluorescence (IF)||14 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||11 Antibodies|
|Immunohistochemistry (IHC)||25 Antibodies|
|Immunohistochemistry (Acetone-fixed) (IHC (af))||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||18 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||28 Antibodies|
|Intracellular Flow Cytometry (ICFC)||6 Antibodies|
|Antigen||Interleukin 3 Receptor, alpha (Low Affinity) (IL3RA) Antibodies|
|Conjugate||This IL3RA antibody is conjugated to PerCP-Cy5.5 Alternatives|
Blocking Reagent (BR), Flow Cytometry (FACS), Immunoprecipitation (IP)
|6 references available|
|Supplier||Log in to see|
Product Details anti-IL3RA AntibodyTarget Details IL3RA Application Details Handling References for anti-IL3RA Antibody (ABIN2660267) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.|
Target Details IL3RAProduct Details anti-IL3RA Antibody Application Details Handling References for anti-IL3RA Antibody (ABIN2660267) Images back to top
|Alternative Name||CD123 (IL3RA Antibody Abstract)|
|Background||CD123 is the 70 kD transmembrane α chain of the IL-3 receptor. Alone, CD123 binds IL-3 with low affinity, when CD123 associates with CDw131 (common β chain), it binds IL-3 with high affinity. CD123 does not transduce intracellular signals upon binding IL-3 and requires the β chain for this function. CD123 is expressed by myeloid precursors, macrophages, dendritic cells, mast cells, basophils, megakaryocytes, and some B cells.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
Application DetailsProduct Details anti-IL3RA Antibody Target Details IL3RA Handling References for anti-IL3RA Antibody (ABIN2660267) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL3RA Antibody Target Details IL3RA Application Details References for anti-IL3RA Antibody (ABIN2660267) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL3RA Antibody (ABIN2660267)Product Details anti-IL3RA Antibody Target Details IL3RA Application Details Handling Images back to top
Manuel, Sehgal, Khan et al.: "An altered maturation and adhesion phenotype of dendritic cells in diseased individuals compared to asymptomatic carriers of human T cell leukemia virus type 1." in: AIDS research and human retroviruses, Vol. 29, Issue 9, pp. 1273-85, 2013 (PubMed).
Charles, Hardwick, Daugas et al.: "Basophils and the T helper 2 environment can promote the development of lupus nephritis." in: Nature medicine, Vol. 16, Issue 6, pp. 701-7, 2010 (PubMed).
Martín-Gayo, Sierra-Filardi, Corbí et al.: "Plasmacytoid dendritic cells resident in human thymus drive natural Treg cell development." in: Blood, Vol. 115, Issue 26, pp. 5366-75, 2010 (PubMed).
Herling, Teitell, Shen et al.: "TCL1 expression in plasmacytoid dendritic cells (DC2s) and the related CD4+ CD56+ blastic tumors of skin." in: Blood, Vol. 101, Issue 12, pp. 5007-9, 2003 (PubMed).
Sun, Woodcock, Rapoport et al.: "Monoclonal antibody 7G3 recognizes the N-terminal domain of the human interleukin-3 (IL-3) receptor alpha-chain and functions as a specific IL-3 receptor antagonist." in: Blood, Vol. 87, Issue 1, pp. 83-92, 1996 (PubMed).
Miyajima, Mui, Ogorochi et al.: "Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5." in: Blood, Vol. 82, Issue 7, pp. 1960-74, 1993 (PubMed).
ImagesProduct Details anti-IL3RA Antibody Target Details IL3RA Application Details Handling References for anti-IL3RA Antibody (ABIN2660267) back to top