anti-Human IL4 Receptor antibody for ELISpot (Capture)

Recommended IL4 Receptor Antibody (supplied by: Log in to see )

Antigen
Interleukin 4 Receptor (IL4R) Antibodies
  • IL4R
  • il-4ra
  • zgc:113063
  • CD124
  • IL-4RA
  • IL4RA
  • Il4ra
  • IL4
  • Il4r
  • interleukin 4 receptor
  • interleukin 4 receptor, alpha
  • IL4R
  • il4r
  • LOC100220266
  • Il4r
  • Il4ra
Reactivity
Human
127
60
10
Host
Mouse
73
64
25
14
1
Clonality
Monoclonal
Conjugate
This IL4 Receptor antibody is un-conjugated
11
9
4
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
ELISA (Capture), ELISpot (Capture) (ELISPOT (Capture)), Intracellular Flow Cytometry (ICFC), Immunoprecipitation (IP), Neutralization (Neut), Western Blotting (WB)
95
59
57
32
28
12
11
7
5
4
3
3
2
2
2
2
2
1
1
1
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Catalog No. ABIN2664183
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2664184 ELISA (Capture) ELISPOT (Capture) ICFC IP Neut WB Mouse IgG2a kappa Log in to see G077F6 3

General

Antigen Interleukin 4 Receptor (IL4R) Antibodies
Reactivity Human
(127), (60), (10)
Host Mouse
(73), (64), (25), (14), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL4 Receptor antibody is un-conjugated
(11), (9), (4), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application ELISA (Capture), ELISpot (Capture) (ELISPOT (Capture)), Intracellular Flow Cytometry (ICFC), Immunoprecipitation (IP), Neutralization (Neut), Western Blotting (WB)
(95), (59), (57), (32), (28), (12), (11), (7), (5), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-IL4 Receptor Antibody

Target Details IL4 Receptor Application Details Handling References for anti-IL4 Receptor antibody (ABIN2664183) Images
Purification The antibody was purified by affinity chromatography.
Clone G077F6
Isotype IgG2a kappa

Target Details IL4 Receptor

Product Details anti-IL4 Receptor Antibody Application Details Handling References for anti-IL4 Receptor antibody (ABIN2664183) Images back to top
Antigen
Alternative Name CD124 (IL4R Antibody Abstract)
Background CD124, also known as the alpha subunit of IL-4R, is a 140 kD transmembrane glycoprotein. It associates with either the common γ -chain (CD132) to form the type I IL-4R complex, which specifically binds IL-4, or with IL-13Ra1 to form the type II IL-4R heterodimeric complex, which binds and transduces signals from either IL-4 or IL-13. A truncated form of IL-4Rα exists in the soluble form in biological fluids. CD124 is expressed on human B and T cells as well as a variety of other hematopoietic and non-hematopoietic cells and cell lines. In B cells, CD124 can bind with IL-4 and IL-13 to regulate IgE antibody production. In T cells, the type I IL-4R (IL-4R/gC) is mostly responsible for Th2 cell expansion by mediating IL-4-dependent activation of the transcription factors in hematopoietic cells. The type II IL-4R (IL-4R/IL-13Ra1) is the main route for non-hematopoietic cell responses to IL-4 or IL-13.
Pathways JAK-STAT Signaling, Positive Regulation of Immune Effector Process

Application Details

Product Details anti-IL4 Receptor Antibody Target Details IL4 Receptor Handling References for anti-IL4 Receptor antibody (ABIN2664183) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL4 Receptor Antibody Target Details IL4 Receptor Application Details References for anti-IL4 Receptor antibody (ABIN2664183) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-IL4 Receptor antibody (ABIN2664183)

Product Details anti-IL4 Receptor Antibody Target Details IL4 Receptor Application Details Handling Images back to top
Background publications

Gilmour, Lavender: "Control of IL-4 expression in T helper 1 and 2 cells." in: Immunology, Vol. 124, Issue 4, pp. 437-44, 2008

Kashiwada, Giallourakis, Pan, Rothman: "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 11, pp. 6382-7, 2001

Hage, Sebald, Reinemer: "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface." in: Cell, Vol. 97, Issue 2, pp. 271-81, 1999

Images

Product Details anti-IL4 Receptor Antibody Target Details IL4 Receptor Application Details Handling References for anti-IL4 Receptor antibody (ABIN2664183) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 4 Receptor (IL4R) antibody (ABIN2664183) anti-Interleukin 4 Receptor (IL4R) antibody
Flow Cytometry (FACS) image for anti-Interleukin 4 Receptor (IL4R) antibody (ABIN2664183) anti-Interleukin 4 Receptor (IL4R) antibody (Image 2)