Browse our IL4 Receptor Proteins (IL4R)

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Interleukin 4 Receptor Proteins (IL4R)
On are 29 Interleukin 4 Receptor (IL4R) Proteins from 11 different suppliers available. Additionally we are shipping IL4 Receptor Antibodies (148) and IL4 Receptor Kits (26) and many more products for this protein. A total of 215 IL4 Receptor products are currently listed.
CD124, IL-4RA, IL4, Il4r, Il4ra, zgc:113063
list all proteins Gene Name GeneID UniProt
IL4R 3566 P24394
IL4R 25084 Q63257
IL4R 16190 P16382

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IL4 Receptor Proteins (IL4R) by Origin

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Top referenced IL4 Receptor Proteins

  1. Human IL4 Receptor Protein expressed in Human Cells - ABIN2002785 : Grabstein, Eisenman, Mochizuki, Shanebeck, Conlon, Hopp, March, Gillis: Purification to homogeneity of B cell stimulating factor. A molecule that stimulates proliferation of multiple lymphokine-dependent cell lines. in The Journal of experimental medicine 1986 (PubMed)
    Show all 6 references for 2002785

  2. Mouse (Murine) IL4 Receptor Protein expressed in Human Cells - ABIN2008742 : Yokota, Arai, de Vries, Spits, Banchereau, Zlotnik, Rennick, Howard, Takebe, Miyatake: Molecular biology of interleukin 4 and interleukin 5 genes and biology of their products that stimulate B cells, T cells and hemopoietic cells. in Immunological reviews 1988 (PubMed)
    Show all 5 references for 2008742

  3. Rat (Rattus) IL4 Receptor Protein expressed in Human Cells - ABIN2009292 : Kotowicz, Callard, Friedrich, Matthews, Klein: Biological activity of IL-4 and IL-13 on human endothelial cells: functional evidence that both cytokines act through the same receptor. in International immunology 1997 (PubMed)
    Show all 5 references for 2009292

  4. Human IL4 Receptor Protein expressed in HEK-293 Cells - ABIN2181320 : Ikizawa, Yanagihara: Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line. in Biochemical and biophysical research communications 2000 (PubMed)

More Proteins for IL4 Receptor Interaction Partners

Cow (Bovine) Interleukin 4 Receptor (IL4R) interaction partners

  1. IL-4 (show IL4 Proteins) may play a role in coordinating the adrenal response to inflammatory stress.

Zebrafish Interleukin 4 Receptor (IL4R) interaction partners

Human Interleukin 4 Receptor (IL4R) interaction partners

  1. Naive CD4+ Tconv cells from subjects with asthma bearing the IL4RR576 mutation show defective induction of iTreg cells and their skewing toward a TH17-like phenotype.

  2. Result showed that exposure of Peripheral Blood-Mesenchymal Stem Cells (PB-MSCs) to Noggin was associated with changes in pattern of CD29/CD184 expression. The expression profile of CD29(+/-)/CD184(-) can be suggested as a robust signature for tracing differentiation of PB-MSCs into neuronal cells.

  3. The promoter methylation levels of GATA3 (show GATA3 Proteins), IL-4 (show IL4 Proteins), and TGF-beta (show TGFB1 Proteins) were significantly higher in active VKH patients than in healthy individuals

  4. results suggest that certain polymorphisms of IL4 (show IL4 Proteins) and IL4R may affect susceptibility to gastrointestinal cancer [meta-analysis]

  5. Study indicates that endogenously expressed IL-4 (show IL4 Proteins) and IL-4Ralpha contribute to the malignant phenotype of pancreatic cancer cells by activating diverse pro-oncogenic signaling pathways.

  6. Polymorphisms in promoter region of IL-4 (show IL4 Proteins) but not IL-4RA genes confer susceptibility to juvenile idiopathic arthritis and may predispose individuals to adaptive immune responses.

  7. The aim of this study was to evaluate the impact of the polymorphisms within interleukin 4 (show IL4 Proteins) (rs2243250, rs2227284), interleukin 4 receptor alpha chain (rs1805010, rs1805011) and interleukin 13 (show IL13 Proteins) (rs20541) genes on the incidence of allergic phenotype in Polish pediatric population.

  8. IL-4 (show IL4 Proteins) -590 and IL-4R Q551R gene polymorphisms are not associated with the susceptibility and the clinical pattern of alopecia areata in Saudi patients.

  9. investigated five SNPs (C-589T and C-33T of IL4 (show IL4 Proteins), G+2044A of IL13 (show IL13 Proteins), A+1902G of IL4Ralpha, and A+896G of TLR4 (show TLR4 Proteins)) in patients with adult onset asthma to evaluate their role in manifestation and severity of asthma

  10. Essential role of endocytosis for interleukin-4-receptor-mediated JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signalling.

Horse (Equine) Interleukin 4 Receptor (IL4R) interaction partners

  1. IL4R plays a role in some cases of recurrent airway obstruction.

Mouse (Murine) Interleukin 4 Receptor (IL4R) interaction partners

  1. a severe asthma-associated polymorphism in the gene encoding the interleukin (IL)-4 receptor alpha chain (Il4ra(R576)) promotes conversion of induced Treg (iTreg) cells toward a T helper 17 (TH17) cell fate. This skewing is mediated by the recruitment by IL-4Ralpha(R576) of the growth-factor-receptor-bound protein 2 (GRB2 (show GRB2 Proteins)) adaptor protein, which drives IL-17 (show IL17A Proteins) expression by activating a pathway that involves ERK (show EPHB2 Proteins), IL-6 (show IL6 Proteins) an...

  2. using mice deficient for IL-4Ralpha, findings show after repeated schistosome infection, levels of regulatory IL-10 (show IL10 Proteins) in the skin were reduced, accompanied by increased numbers of MHC-IIhigh cells and CD4 (show CD4 Proteins)+ T cells in the skin; study highlights a mechanism through which IL-4Ralpha may regulate the immune system through the induction of IL-10 (show IL10 Proteins) and regulation of Fas (show FAS Proteins)/FasL (show FASL Proteins) mediated cell death

  3. IL-4Ralpha expression on CD4 (show CD4 Proteins)+ T cells plays a major role in the pathogenesis of chronic asthma and the regulation of allergen-specific TH17 responses, whereas acute asthmatic pathology and TH2 responses developed in the absence of IL-4Ralpha-responsive CD4 (show CD4 Proteins)+ T cells and IL-4 (show IL4 Proteins).

  4. Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications.

  5. Il4ra mRNA expression was significantly increased after stroke.

  6. functional synergy between Flt3 and IL-4R signaling is critical for Stat-mediated regulation of sterile gamma1 germ-line transcripts and CSR to IgG1

  7. Immunostaining and semiquantitative analysis revealed increased presence of IL4ra in the pulmonary vasculature of patients with connective tissue disease-associated PAH and Schistosoma-PAH compared with normal control subjects.

  8. data provide new insights into the molecular mechanisms governing IL-4Ralpha-induced responses, and may provide new therapeutic tools to target IL-4 (show IL4 Proteins) in allergy and asthma

  9. IL4R mediates enhanced glucose and glutamine metabolism in breast cancer cells.

  10. Data show that fibrillin-1 (FBN1 (show FBN1 Proteins)) modulates bone marrow mesenchymal stem cells (BMMSCs) lineage differentiation via IL4 receptor alpha/mTOR (show FRAP1 Proteins) protein signaling.

IL4 Receptor (IL4R) Protein Profile

Protein Summary

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants.

Alternative names and synonyms associated with IL4 Receptor (IL4R)

  • interleukin 4 receptor (IL4R)
  • interleukin 4 receptor (il4r)
  • interleukin 4 receptor (LOC100220266)
  • interleukin 4 receptor (Il4r)
  • interleukin 4 receptor, alpha (Il4ra)
  • CD124 protein
  • IL-4RA protein
  • IL4 protein
  • Il4r protein
  • Il4ra protein
  • zgc:113063 protein

Protein level used designations for Interleukin 4 Receptor Proteins (IL4R)

interleukin 4 receptor alpha chain , interleukin-4 receptor alpha chain , interleukin-4 receptor subunit alpha , interleukin 4 receptor , IL-4RA-like protein 1 , il-4alpha , interleukin 4 receptor alpha , soluble IL-4 receptor alpha , interleukin-4 receptor subunit alpha-like , IL-4 receptor subunit alpha , IL4R nirs variant 1 , IL-4R subunit alpha , IL-4R-alpha , IL-4RA , interleukin 4 receptor, alpha , interleukin 4 tv3 , interleukin 4 tv5 , interleukin-4 receptor alpha-chain , IL-4 receptor alpha chain

404154 Bos taurus
416585 Gallus gallus
454005 Pan troglodytes
489957 Canis lupus familiaris
503594 Danio rerio
705404 Macaca mulatta
100220266 Taeniopygia guttata
100412639 Callithrix jacchus
100449812 Pongo abelii
100606206 Nomascus leucogenys
3566 Homo sapiens
25084 Rattus norvegicus
397614 Sus scrofa
791252 Equus caballus
16190 Mus musculus
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