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|Antigen||Interleukin 7 Receptor (IL7R) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This IL7R antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
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Product Details anti-IL7R AntibodyTarget Details IL7R Application Details Handling Images
|Specificity||This antibody recognizes Interleukin 7 Receptor Alpha Chain (IL7R). This phospho-specific polyclonal antibody reacts with Mouse IL-7 pY449 and shows minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.|
Species reactivity (expected):Human, Rat.
Species reactivity (tested):Mouse.
|Immunogen||Synthetic peptide corresponding to residues near Tyr449 of Mouse IL-7 protein|
Target Details IL7RProduct Details anti-IL7R Antibody Application Details Handling Images back to top
|Alternative Name||CD127 / IL7R (IL7R Antibody Abstract)|
|Background||Interleukin 7 Receptor (IL7R) is a receptor for interleukin 7 (IL7). The function of IL7R requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).Synonyms: IL-7R-alpha, IL7 receptor alpha, Interleukin-7 receptor subunit alpha|
|Research Area||CD Antigens, Surface Receptors of Immune Cells, Cytokines, Immunology, Virology, Inflammation, Cancer|
|Pathways||JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size|
Application DetailsProduct Details anti-IL7R Antibody Target Details IL7R Handling Images back to top
Immunohistochemistry on paraffin sections: 5 μg/mL. Western blot: 1/1000 - 1/10000. ELISA: 1/100000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL7R Antibody Target Details IL7R Application Details Images back to top
|Buffer||0.02 M Potassium Phosphate, pH 7.2 with 0.15 M Sodium Chloride, 0.01 % Sodium Azide|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
ImagesProduct Details anti-IL7R Antibody Target Details IL7R Application Details Handling back to top