anti-Human IL7R antibody for Immunoprecipitation

Recommended IL7R Antibody (supplied by: Log in to see )

Antigen
Interleukin 7 Receptor (IL7R) Antibodies
  • IL7R
  • CD127
  • IL-7Ralpha
  • CDW127
  • IL-7R-alpha
  • IL7RA
  • ILRA
  • IL-7RA
  • interleukin 7 receptor
  • IL7R
  • LOC100226205
  • Il7r
Reactivity
Human
230
219
38
3
2
1
1
Host
Mouse
134
127
110
18
7
4
Clonality
Monoclonal
Conjugate
This IL7R antibody is conjugated to PE/Dazzle™ 594
28
24
24
18
16
13
10
9
9
8
8
8
7
6
5
5
5
5
5
5
5
5
5
5
3
2
2
2
2
2
2
2
2
1
1
1
Application
Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Stimulation (St)
186
184
73
66
49
26
14
12
12
11
7
4
4
4
3
3
2
2
1
1
1
1
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Catalog No. ABIN2659645
Contact our Customer Service for availability and price in your country.
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN1859442 ICC IHC IP WB Rabbit IgG AA 173-260 Log in to see Polyclonal
1 ABIN259910 ELISA IHC IP WB Rabbit pTyr449 Log in to see Polyclonal
1 ABIN2656905 IP WB APC Mouse IgG1 kappa Log in to see A019D5 6
1 ABIN2656906 IP WB APC Mouse IgG1 kappa Log in to see A019D5 6
1 ABIN2659646 BR CyTOF FACS IHC IP St PE/Dazzle™ 594 Mouse IgG1 kappa Log in to see A019D5 6
1 ABIN786861 FACS IP Neut Mouse IgG1 Log in to see R34-34 39

General

Antigen Interleukin 7 Receptor (IL7R) Antibodies
Reactivity Human
(230), (219), (38), (3), (2), (1), (1)
Host Mouse
(134), (127), (110), (18), (7), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This IL7R antibody is conjugated to PE/Dazzle™ 594
(28), (24), (24), (18), (16), (13), (10), (9), (9), (8), (8), (8), (7), (6), (5), (5), (5), (5), (5), (5), (5), (5), (5), (5), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Blocking Reagent (BR), Cytometry by Time of Flight (CyTOF), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Stimulation (St)
(186), (184), (73), (66), (49), (26), (14), (12), (12), (11), (7), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-IL7R Antibody

Target Details IL7R Application Details Handling ProductDetails: References for anti-IL7R antibody (ABIN2659645) Images
Purification The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions. The solution is free of unconjugated PE/Dazzle™ 594 and unconjugated antibody.
Clone A019D5
Isotype IgG1 kappa

Target Details IL7R

Product Details anti-IL7R Antibody Application Details Handling ProductDetails: References for anti-IL7R antibody (ABIN2659645) Images back to top
Antigen
Alternative Name CD127 (IL7R Antibody Abstract)
Background CD127 is a 60-90 kD type I transmembrane glycoprotein also known as IL-7 receptor α chain or IL-7Rα. It forms a heterodimer with the common γ chain (γc or CD132) which is shared with the receptors for IL-2, IL-4, IL-9, IL-13, IL-15, and IL-21. CD127 is expressed on immature B cells through early pre-B stage cells, thymocytes (except CD4/CD8 double positive thymocytes), peripheral T cells, and bone marrow stromal cells. CD127 has been reported to be a useful marker for identifying memory and effector T cells. Studies have shown that CD127 expression is down-modulated on Treg cells. It can be used as a marker for differentiation of Treg and conventional T cells. The ligation of IL-7 with its receptor is important for stimulation of mature and immature T cells as well as immature B cell proliferation and development.
Pathways JAK-STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size

Application Details

Product Details anti-IL7R Antibody Target Details IL7R Handling ProductDetails: References for anti-IL7R antibody (ABIN2659645) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-IL7R Antibody Target Details IL7R Application Details ProductDetails: References for anti-IL7R antibody (ABIN2659645) Images back to top
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Protect from prolonged exposure to light. Do not freeze.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

ProductDetails: References for anti-IL7R antibody (ABIN2659645)

Product Details anti-IL7R Antibody Target Details IL7R Application Details Handling Images back to top
Background publications

Liu, Putnam, Xu-Yu, Szot, Lee, Zhu, Gottlieb, Kapranov, Gingeras, Fazekas de St Groth, Clayberger, Soper, Ziegler, Bluestone: "CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells." in: The Journal of experimental medicine, Vol. 203, Issue 7, pp. 1701-11, 2006

Huster, Busch, Schiemann, Linkemann, Kerksiek, Wagner, Busch: "Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8+ memory T cell subsets." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 15, pp. 5610-5, 2004

Pillai, Torok-Storb, Iwata: "Expression and function of IL-7 receptors in marrow stromal cells." in: Leukemia & lymphoma, Vol. 45, Issue 12, pp. 2403-8, 2004

He, Malek: "The structure and function of gamma c-dependent cytokines and receptors: regulation of T lymphocyte development and homeostasis." in: Critical reviews in immunology, Vol. 18, Issue 6, pp. 503-24, 1999

Sudo, Nishikawa, Ohno, Akiyama, Tamakoshi, Yoshida, Nishikawa: "Expression and function of the interleukin 7 receptor in murine lymphocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 19, pp. 9125-9, 1993

Morrissey, Goodwin, Nordan, Anderson, Grabstein, Cosman, Sims, Lupton, Acres, Reed: "Recombinant interleukin 7, pre-B cell growth factor, has costimulatory activity on purified mature T cells." in: The Journal of experimental medicine, Vol. 169, Issue 3, pp. 707-16, 1989

Images

Product Details anti-IL7R Antibody Target Details IL7R Application Details Handling ProductDetails: References for anti-IL7R antibody (ABIN2659645) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Interleukin 7 Receptor (IL7R) antibody (PE/Dazzle™ 594) (ABIN2659645) anti-Interleukin 7 Receptor (IL7R) antibody (PE/Dazzle™ 594)
Flow Cytometry (FACS) image for anti-Interleukin 7 Receptor (IL7R) antibody (PE/Dazzle™ 594) (ABIN2659645) anti-Interleukin 7 Receptor (IL7R) antibody (PE/Dazzle™ 594) (Image 2)