Browse our IL7R Proteins (IL7R)

Full name:
Interleukin 7 Receptor Proteins (IL7R)
On are 31 Interleukin 7 Receptor (IL7R) Proteins from 11 different suppliers available. Additionally we are shipping IL7R Antibodies (385) and IL7R Kits (27) and many more products for this protein. A total of 459 IL7R products are currently listed.
CD127, CDW127, IL-7R-alpha, IL-7RA, IL-7Ralpha, IL7R, IL7RA, ILRA
list all proteins Gene Name GeneID UniProt
IL7R 16197 P16872
IL7R 3575 P16871
IL7R 294797  

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IL7R Proteins (IL7R) by Origin

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Top referenced IL7R Proteins

  1. Human IL7R Protein expressed in Human Cells - ABIN2003675 : Sudo, Nishikawa, Ohno, Akiyama, Tamakoshi, Yoshida, Nishikawa: Expression and function of the interleukin 7 receptor in murine lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 4 references for 2003675

  2. Mouse (Murine) IL7R Protein expressed in Human Cells - ABIN2007306 : Park, Martin, Garka, Gliniak, Di Santo, Muller, Largaespada, Copeland, Jenkins, Farr, Ziegler, Morrissey, Paxton, Sims: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. in The Journal of experimental medicine 2000 (PubMed)
    Show all 4 references for 2007306

  3. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009137 : Pandey, Ozaki, Baumann, Levin, Puel, Farr, Ziegler, Leonard, Lodish: Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. in Nature immunology 2001 (PubMed)
    Show all 4 references for 2009137

  4. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009136 : Kaech, Tan, Wherry, Konieczny, Surh, Ahmed: Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. in Nature immunology 2003 (PubMed)
    Show all 4 references for 2009136

  5. Human IL7R Protein expressed in HEK-293 Cells - ABIN2181401 : McElroy, Dohm, Walsh: Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. in Structure (London, England : 1993) 2009 (PubMed)

More Proteins for IL7R Interaction Partners

Rhesus Monkey Interleukin 7 Receptor (IL7R) interaction partners

  1. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.

  2. The CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.

Mouse (Murine) Interleukin 7 Receptor (IL7R) interaction partners

  1. IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver

  2. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (show TSLP Proteins) can replace IL-7 (show IL7 Proteins) in providing these signals.

  3. Bcl6 (show BCL6 Proteins) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Proteins) axis.

  4. results suggest that LNK (show SH2B3 Proteins) suppresses IL-7R/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (show SH2B3 Proteins) mutations.

  5. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (show INS Proteins) resistance in mice.

  6. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.

  7. Data show the contribution of IL-23/IL-23 (show IL23A Proteins) receptor (show IL23R Proteins) and IL-7/IL-7 (show IL7 Proteins) receptor signaling in Th17 and Th1 (show HAND1 Proteins) cell dynamics during experimental autoimmune encephalomyelitis (EAE).

  8. Inhibition of the IL-7 (show IL7 Proteins) receptor inhibits tumor growth in murine models of melanoma.

  9. The combined loss of Gads (show GRAP2 Proteins) and CD127 reveals a novel function of Gads (show GRAP2 Proteins) prior to T cell receptor beta expression

  10. Results provided evidence that IL-7 (show IL7 Proteins)/IL-7R induce VEGF-D (show Figf Proteins) upregulation and promote lymphangiogenesis via c-Fos/c-Jun (show JUN Proteins) pathway in lung cancer.

Human Interleukin 7 Receptor (IL7R) interaction partners

  1. IL-7 (show IL7 Proteins) has a role inducing epitope masking of gammac protein in IL-7 (show IL7 Proteins) receptor signaling complex

  2. The results of this study showed that IL-17 (show IL17A Proteins) receptor (IL-17R) were clearly up regulated in mesial temporal lobe epilepsy at both mRNA and protein levels, compared with control.

  3. the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 (show PTPN22 Proteins) c.1858C>T (rs2476601), TLR4 (show TLR4 Proteins) c.896A>G (rs4986790) and TLR4 (show TLR4 Proteins) c.1196C>T (rs4986791), IL7R c.197T>C (rs1494555) and IL7R c.412G>A (rs1494558).

  4. The interleukin-7 receptor alpha (IL-7Ralpha) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in both T-cell ALL and B-cell precursor ALL. Therapeutic targeting of the IL-7Ralpha signaling pathways may lead to improved outcomes in a subset of patients.

  5. Therefore, generalized CD8 (show CD8A Proteins)+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7 (show IL7 Proteins)-mediated signalling and survival, independent of CD127 expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8 (show CD8A Proteins)+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health.

  6. These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (show TSLP Proteins) can replace IL-7 (show IL7 Proteins) in providing these signals.

  7. Study showed that a genetic variant in the 5' UTR of DDX39B (show DDX39 Proteins) reduces translation of DDX39B (show DDX39 Proteins) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (show DDX39 Proteins) variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.

  8. study identifies casein kinase 2 as a major player in the effects of interleukin-7 (show IL7 Proteins) and interleukin-7 receptor in T-cell acute lymphoblastic leukemia

  9. CD45RA distinguishes CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus-mediated immunosuppression.

  10. In summary, our study demonstrates that IL-7 (show IL7 Proteins)/IL-7R axis promotes the invasion and migration of prostate cancer cells, through activation of AKT (show AKT1 Proteins)/NF-kappaB (show NFKB1 Proteins) pathway and upregulation of MMP-3 (show MMP3 Proteins) and MMP-7 (show MMP7 Proteins) expression

Horse (Equine) Interleukin 7 Receptor (IL7R) interaction partners

  1. Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.

IL7R Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Alternative names and synonyms associated with IL7R

  • interleukin 7 receptor (IL7R)
  • interleukin 7 receptor (LOC100226205)
  • interleukin 7 receptor (Il7r)
  • CD127 protein
  • CDW127 protein
  • IL-7R-alpha protein
  • IL-7RA protein
  • IL-7Ralpha protein
  • IL7R protein
  • IL7RA protein
  • ILRA protein

Protein level used designations for Interleukin 7 Receptor Proteins (IL7R)

interleukin 7 receptor , interleukin-7 receptor subunit alpha-like , IL-7 receptor alpha chain , IL-7 receptor subunit alpha , IL-7R subunit alpha , IL-7R-alpha , IL-7RA , interleukin 7 receptor alpha chain , interleukin-7 receptor subunit alpha , CD127 antigen , interleukin 7 receptor isoform H5-6 , Interleukin-7 receptor subunit alpha-like protein , Interleukin-7 receptor subunit alpha

699869 Macaca mulatta
100226205 Taeniopygia guttata
100343726 Oryctolagus cuniculus
100461835 Pongo abelii
100583768 Nomascus leucogenys
16197 Mus musculus
3575 Homo sapiens
294797 Rattus norvegicus
100034169 Equus caballus
612582 Canis lupus familiaris
521554 Bos taurus
100397720 Callithrix jacchus
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