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We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.
The CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.
this study shows that short-term blockade of IL-7Ralpha induces detectable changes in co-inhibitory receptor expression and Treg frequencies in peripheral blood of NOD mice
results indicate that the induction of IL-7Ralpha expression on dendritic cells (DCs) is critical for thymic stromal lymphopoietin (show TSLP Proteins) responsiveness and that IL-4 (show IL4 Proteins) can upregulate IL-7Ralpha on DCs.
IL-7RA role in hematopoiesis and development of the lympho-myeloid progenitors in the developing fetal liver
These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP (show TSLP Proteins) can replace IL-7 (show IL7 Proteins) in providing these signals.
Bcl6 (show BCL6 Proteins) promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a (show STAT5A Proteins) axis.
results suggest that LNK (show SH2B3 Proteins) suppresses IL-7R/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (show SH2B3 Proteins) mutations.
The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (show INS Proteins) resistance in mice.
This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.
Data show the contribution of IL-23/IL-23 (show IL23A Proteins) receptor (show IL23R Proteins) and IL-7/IL-7 (show IL7 Proteins) receptor signaling in Th17 and Th1 (show HAND1 Proteins) cell dynamics during experimental autoimmune encephalomyelitis (EAE).
Inhibition of the IL-7 (show IL7 Proteins) receptor inhibits tumor growth in murine models of melanoma.
Tuberculosis patients had lower soluble IL-7R and higher IL-7 (show IL7 Proteins) plasma concentrations as compared to healthy contacts.
CD56 (show NCAM1 Proteins)(bright) NK IL-7Ralpha expression negatively associates with HCV level, and IL-7 (show IL7 Proteins)-induced NK function is impaired during HCV and HIV infections
IL-7 (show IL7 Proteins) has a role inducing epitope masking of gammac protein in IL-7 (show IL7 Proteins) receptor signaling complex
The results of this study showed that IL-17 (show IL17A Proteins) receptor (IL-17R) were clearly up regulated in mesial temporal lobe epilepsy at both mRNA and protein levels, compared with control.
the coding regions of 17 genes involved in the regulation of the immune response were determined by massive parallel sequencing. The analysis revealed 39 nonsynonymous SNPs that lead to amino acid substitutions, including the following informative genetic markers: PTPN22 (show PTPN22 Proteins) c.1858C>T (rs2476601), TLR4 (show TLR4 Proteins) c.896A>G (rs4986790) and TLR4 (show TLR4 Proteins) c.1196C>T (rs4986791), IL7R c.197T>C (rs1494555) and IL7R c.412G>A (rs1494558).
The interleukin-7 receptor alpha (IL-7Ralpha) signaling pathways are prime therapeutic targets because these pathways harbor genetic aberrations in both T-cell ALL and B-cell precursor ALL. Therapeutic targeting of the IL-7Ralpha signaling pathways may lead to improved outcomes in a subset of patients.
Therefore, generalized CD8 (show CD8A Proteins)+ T-cell impairment in HCV infection is characterized, in part, by impaired IL-7 (show IL7 Proteins)-mediated signalling and survival, independent of CD127 expression. This impairment is more pronounced in the liver and may be associated with an increased potential for apoptosis. This generalized CD8 (show CD8A Proteins)+ T-cell impairment represents an important immune dysfunction in chronic HCV infection that may alter patient health.
Study showed that a genetic variant in the 5' UTR of DDX39B (show DDX39 Proteins) reduces translation of DDX39B (show DDX39 Proteins) mRNAs and increases multiple sclerosis (MS) risk. Importantly, this DDX39B (show DDX39 Proteins) variant showed strong genetic & functional epistasis with allelic variants in IL7R exon 6; study establishes the occurrence of biological epistasis in humans & provides mechanistic insight into the regulation of IL7R exon 6 splicing & its impact on MS risk.
study identifies casein kinase 2 as a major player in the effects of interleukin-7 (show IL7 Proteins) and interleukin-7 receptor in T-cell acute lymphoblastic leukemia
Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).
interleukin 7 receptor
, interleukin-7 receptor subunit alpha-like
, IL-7 receptor alpha chain
, IL-7 receptor subunit alpha
, IL-7R subunit alpha
, interleukin 7 receptor alpha chain
, interleukin-7 receptor subunit alpha
, CD127 antigen
, interleukin 7 receptor isoform H5-6
, Interleukin-7 receptor subunit alpha-like protein
, Interleukin-7 receptor subunit alpha