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Browse our IL7R Proteins (IL7R)

Full name:
Interleukin 7 Receptor Proteins (IL7R)
On www.antibodies-online.com are 28 Interleukin 7 Receptor (IL7R) Proteins from 10 different suppliers available. Additionally we are shipping IL7R Antibodies (268) and IL7R Kits (25) and many more products for this protein. A total of 337 IL7R products are currently listed.
Synonyms:
CD127, CDW127, IL-7R-alpha, IL-7RA, IL-7Ralpha, IL7R, IL7RA, ILRA
list all proteins Gene Name GeneID UniProt
IL7R 16197 P16872
IL7R 3575 P16871
IL7R 294797  

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IL7R Proteins (IL7R) by Origin

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Top referenced IL7R Proteins

  1. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009137 : Sudo, Nishikawa, Ohno, Akiyama, Tamakoshi, Yoshida, Nishikawa: Expression and function of the interleukin 7 receptor in murine lymphocytes. in Proceedings of the National Academy of Sciences of the United States of America 1993 (PubMed)
    Show all 4 references for ABIN2009137

  2. Human IL7R Protein expressed in Human Cells - ABIN2003673 : Park, Martin, Garka, Gliniak, Di Santo, Muller, Largaespada, Copeland, Jenkins, Farr, Ziegler, Morrissey, Paxton, Sims: Cloning of the murine thymic stromal lymphopoietin (TSLP) receptor: Formation of a functional heteromeric complex requires interleukin 7 receptor. in The Journal of experimental medicine 2000 (PubMed)
    Show all 4 references for ABIN2003673

  3. Mouse (Murine) IL7R Protein expressed in Human Cells - ABIN2007306 : Pandey, Ozaki, Baumann, Levin, Puel, Farr, Ziegler, Leonard, Lodish: Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin. in Nature immunology 2001 (PubMed)
    Show all 4 references for ABIN2007306

  4. Rat (Rattus) IL7R Protein expressed in Human Cells - ABIN2009136 : Kaech, Tan, Wherry, Konieczny, Surh, Ahmed: Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. in Nature immunology 2003 (PubMed)
    Show all 4 references for ABIN2009136

  5. Human IL7R Protein expressed in HEK-293 Cells - ABIN2181401 : McElroy, Dohm, Walsh: Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. in Structure (London, England : 1993) 2009 (PubMed)

More Proteins for IL7R Interaction Partners

Rhesus Monkey Interleukin 7 Receptor (IL7R) interaction partners

  1. We found that the percentage of T cells expressing IL-7R was significantly lower in both CD4(+) and CD8(+) T cell subsets blood and tissues in SIV-infected macaques than in healthy animals.

  2. The CD4 (show CD4 Proteins)+CD25 (show IL2RA Proteins)+CD127low phenotype is found to be characteristic of regulatory cells found in mice and in rhesus macaques.

Mouse (Murine) Interleukin 7 Receptor (IL7R) interaction partners

  1. results suggest that LNK (show SH2B3 Proteins) suppresses IL-7R/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (show SH2B3 Proteins) mutations.

  2. The IL-7R plays an important role in the induction of HFD-induced adipogenesis and insulin (show INS Proteins) resistance in mice.

  3. This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.

  4. Data show the contribution of IL-23/IL-23 (show IL23A Proteins) receptor (show IL23R Proteins) and IL-7/IL-7 (show IL7 Proteins) receptor signaling in Th17 and Th1 (show HAND1 Proteins) cell dynamics during experimental autoimmune encephalomyelitis (EAE).

  5. Inhibition of the IL-7 (show IL7 Proteins) receptor inhibits tumor growth in murine models of melanoma.

  6. The combined loss of Gads (show GRAP2 Proteins) and CD127 reveals a novel function of Gads (show GRAP2 Proteins) prior to T cell receptor beta expression

  7. Results provided evidence that IL-7 (show IL7 Proteins)/IL-7R induce VEGF-D (show Figf Proteins) upregulation and promote lymphangiogenesis via c-Fos/c-Jun (show JUN Proteins) pathway in lung cancer.

  8. data suggest that IL-7Ralpha Tyr (show TYR Proteins)(449) was essential for IL-7Ralpha signaling in bone marrow B cell development and survival.

  9. The development and survival but not function of follicular B cells is dependent on IL-7Ralpha Tyr449 signaling.

  10. interleukin-7 receptor mutants induce early T cell precursor acute lymphoblastic leukemia by the block of thymocyte differentiation at the double negative 2 stage at which myeloid lineage and T lymphocyte developmental potential coexist.

Human Interleukin 7 Receptor (IL7R) interaction partners

  1. Immunophenotyping with CD135 (show FLT3 Proteins) and CD117 predicts the FLT3 (show FLT3 Proteins), IL-7R and TLX3 (show TLX3 Proteins) gene mutations in childhood T-cell acute leukemia.

  2. A decrease of CD4 (show CD4 Proteins)(+) CD25 (show IL2RA Proteins)(+) CD127(low) FoxP3 (show FOXP3 Proteins)(+) regulatory T cells with impaired suppressive function had been found in untreated ulcerative colitis patients.

  3. results suggest that LNK (show SH2B3 Proteins) suppresses IL-7R/JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins) signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK (show SH2B3 Proteins) mutations.

  4. Pretransplant recipient circulating CD4 (show CD4 Proteins)+CD127lo/-TNFR2 (show TNFRSF1B Proteins)+ Treg cell is potentially a simpler alternative to Treg cell function as a pretransplant recipient immune marker for acute kidney injury.

  5. CD4 (show CD4 Proteins)+CD45RO+CD25 (show IL2RA Proteins)-/lowCD127+: CD4 (show CD4 Proteins)+CD45RO+CD25hiCD127-/low ratio in peripheral blood indicates heart transplant recipients at risk for cardiac allograft vasculopathy.

  6. Data suggest that the lack of IL-7 receptor alpha chain (IL7Ralpha) expression, associated with hypermethylation of the IL7R promoter, in T cells restricts T-cell development in Schimke immuno-osseous dysplasia (SIOD) patients.

  7. Substitution of the first 10 Nterminal residues or deletion of residues 17-21 prevented Tat (show TAT Proteins) from interacting with and down regulating CD127 from the cell surface.

  8. In view of the important role IL-7 (show IL7 Proteins) plays in lymphocyte proliferation, homeostasis and survival, down regulation of CD127 by Tat (show TAT Proteins) likely plays a central role in immune dysregulation and CD4 (show CD4 Proteins) T-cell decline

  9. This study then provides evidence that soluble factor(s) are responsible for low CD127 expression on circulating CD8 (show CD8A Proteins) T-cells in HIV+ individuals and further implicates Tat (show TAT Proteins) in suppressing this receptor essential to CD8 (show CD8A Proteins) T-cell proliferation and function.

  10. Findings indicate that IL7 (show IL7 Proteins) receptor (IL7R) and c-myc (show MYC Proteins) expression as intrinsic biomarkers that can predict the fate of CD8 (show CD8A Proteins)+ T effector cells after adoptive transfer.

Horse (Equine) Interleukin 7 Receptor (IL7R) interaction partners

  1. Data show a statistically significant association between a single nucleotide polymorphism (SNP) within the interleukin 7 receptor-encoding gene (IL7R) with high R. equi burden.

IL7R Protein Profile

Protein Summary

The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID).

Alternative names and synonyms associated with IL7R

  • interleukin 7 receptor (IL7R)
  • interleukin 7 receptor (LOC100226205)
  • interleukin 7 receptor (Il7r)
  • CD127 protein
  • CDW127 protein
  • IL-7R-alpha protein
  • IL-7RA protein
  • IL-7Ralpha protein
  • IL7R protein
  • IL7RA protein
  • ILRA protein

Protein level used designations for Interleukin 7 Receptor Proteins (IL7R)

interleukin 7 receptor , interleukin-7 receptor subunit alpha-like , IL-7 receptor alpha chain , IL-7 receptor subunit alpha , IL-7R subunit alpha , IL-7R-alpha , IL-7RA , interleukin 7 receptor alpha chain , interleukin-7 receptor subunit alpha , CD127 antigen , interleukin 7 receptor isoform H5-6 , Interleukin-7 receptor subunit alpha-like protein , Interleukin-7 receptor subunit alpha

GENE ID SPECIES
699869 Macaca mulatta
100226205 Taeniopygia guttata
100343726 Oryctolagus cuniculus
100461835 Pongo abelii
100583768 Nomascus leucogenys
16197 Mus musculus
3575 Homo sapiens
294797 Rattus norvegicus
100034169 Equus caballus
612582 Canis lupus familiaris
521554 Bos taurus
100397720 Callithrix jacchus
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