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|Application / Reactivity||Human|
|Flow Cytometry (FACS)||13 Antibodies|
|Functional Studies (Func)||4 Antibodies|
|Immunocytochemistry (ICC)||1 Antibodies|
|Immunofluorescence (IF)||4 Antibodies|
|Immunohistochemistry (IHC)||29 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||5 Antibodies|
|Neutralization (Neut)||3 Antibodies|
|Western Blotting (WB)||29 Antibodies|
|Antigen||Interleukin 9 Receptor (IL9R) Antibodies|
|Conjugate||This IL9 Receptor antibody is un-conjugated Alternatives|
Flow Cytometry (FACS), Immunohistochemistry (IHC)
|3 references available|
|Supplier||Log in to see|
Product Details anti-IL9 Receptor AntibodyTarget Details IL9 Receptor Application Details Handling References for anti-IL9 Receptor Antibody (ABIN2665535) Images
|Purification||The LEAF™ (Low Endotoxin, Azide-Free) antibody was purified by affinity chromatography.|
|Sterility||0.2 μm filtered|
Endotoxin level is <0.1 EU/μg of the protein (<0.01 ng/μg of the protein) as determined by the LAL test.
Target Details IL9 ReceptorProduct Details anti-IL9 Receptor Antibody Application Details Handling References for anti-IL9 Receptor Antibody (ABIN2665535) Images back to top
|Alternative Name||CD129 (IL9R Antibody Abstract)|
|Background||CD129 is known as the 57 kD IL-9 receptor. It is a member of the hematopoietin receptor superfamily. Although the α -chain of the receptor binds IL-9 with high affinity, interaction with the γ-chain (CD132) of the IL-2 receptor is required for signaling. The IL-9 receptor is expressed at low levels on eosinophils, mast cells, macrophages, B lymphocytes, T lymphocytes, and erythroid progenitors. IL-9 receptor binding initiates STAT activation required for the proliferative and anti-apoptotic effects of this cytokine. In humans, signals from the IL-9 receptor appear to be critical for intrathymic T cell development. IL-9 binding has been shown to increase IL-5 receptor expression and promote survival in human eosinophils.|
Application DetailsProduct Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Handling References for anti-IL9 Receptor Antibody (ABIN2665535) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Application Details References for anti-IL9 Receptor Antibody (ABIN2665535) Images back to top
|Handling Advice||This LEAF™ solution contains no preservative, handle under aseptic conditions|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-IL9 Receptor Antibody (ABIN2665535)Product Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Application Details Handling Images back to top
Pilette, Ouadrhiri, Van Snick et al.: "IL-9 inhibits oxidative burst and TNF-alpha release in lipopolysaccharide-stimulated human monocytes through TGF-beta." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 168, Issue 8, pp. 4103-11, 2002 (PubMed).
De Smedt, Verhasselt, Kerre et al.: "Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 164, Issue 4, pp. 1761-7, 2000 (PubMed).
Demoulin, Uyttenhove, Van Roost et al.: "A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9." in: Molecular and cellular biology, Vol. 16, Issue 9, pp. 4710-6, 1996 (PubMed).
ImagesProduct Details anti-IL9 Receptor Antibody Target Details IL9 Receptor Application Details Handling References for anti-IL9 Receptor Antibody (ABIN2665535) back to top