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anti-Dog (Canine) JAK1 antibody for Immunofluorescence

Recommended JAK1 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 1 (JAK1) Antibodies
  • AA960307
  • C130039L05Rik
  • jak1
  • JAK1
  • JAK1A
  • JAK1B
  • JNK
  • JNK1
  • JTK3
  • wu:fb93e10
Epitope
AA 551-766
30
17
14
13
13
8
7
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
95
79
60
5
5
4
4
1
Host
Mouse
102
5
1
1
Clonality
Monoclonal
Conjugate
This JAK1 antibody is un-conjugated
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
74
53
46
11
11
10
4
4
2
2
2
1
Supplier
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Catalog No. ABIN967842
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Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.3157438 ABIN967841 IF IP IHC WB Mouse IgG1, kappa AA 551-766 Log in to see 73-JAK1 5
0.3157438 ABIN2704932 IC IF IHC WB Rabbit C-Term Log in to see Polyclonal

Top referenced anti-JAK1 antibody for Immunofluorescence

  • Chicken Monoclonal JAK1 Primary Antibody for IF, IP - ABIN967842 (5 Publications): Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001 (PubMed)

  • Chicken Monoclonal JAK1 Primary Antibody for IF, IP - ABIN967841 (5 Publications): Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. in The Journal of experimental medicine 2001 (PubMed)

Similar anti-JAK1 Antibodies

Application / Reactivity Human Mouse (Murine) Rat (Rattus) Chicken Dog (Canine) Frog
Western Blotting (WB) 64 Antibodies 54 Antibodies 39 Antibodies 4 Antibodies 4 Antibodies 2 Antibodies
Immunoprecipitation (IP) 5 Antibodies 2 Antibodies 2 Antibodies 2 Antibodies 2 Antibodies 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 10 Antibodies 9 Antibodies 7 Antibodies
Immunohistochemistry (IHC) 54 Antibodies 41 Antibodies 37 Antibodies 4 Antibodies 4 Antibodies

General

Antigen Janus Kinase 1 (JAK1) Antibodies
Epitope AA 551-766
(30), (17), (14), (13), (13), (8), (7), (4), (3), (3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Chicken, Dog (Canine), Frog, Human, Mouse (Murine), Rat (Rattus)
(95), (79), (60), (5), (5), (4), (4), (1)
Host Mouse
(102), (5), (1), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This JAK1 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(74), (53), (46), (11), (11), (10), (4), (4), (2), (2), (2), (1)
Pubmed 5 references available
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Product Details anti-JAK1 Antibody

Target Details JAK1 Application Details Handling References for anti-JAK1 Antibody (ABIN967842) Images
Cross-Reactivity Dog (Canine), Rat (Rattus), Mouse (Murine), Chicken, Frog
Characteristics 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
5. For fluorochrome spectra and suitable instrument settings, please refer to us.
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human JAK1 aa. 551-766
Clone 73-JAK1
Isotype IgG1, kappa

Target Details JAK1

Product Details anti-JAK1 Antibody Application Details Handling References for anti-JAK1 Antibody (ABIN967842) Images back to top
Antigen
Alternative Name JAK1 (JAK1 Antibody Abstract)
Background The JAK family of receptor-associated protein kinases is directly involved in interferon (IFN) response pathways. The JAK family contains at least three members: JAK1, JAK2, and Tyk2. Each protein is approximately 130 kDa and contains a C-terminal tyrosine kinase domain, an adjacent kinase or kinase-related domain, and five other domains that are highly conserved among family members. In several human and murine cell lines, JAK1 is rapidly tyrosine phosphorylated in response to IFN-alpha and IFN-gamma. JAK1 is required for the phosphorylation of the transcription factor Stat1 (p91), in response to IFNs-alpha or IFN-gamma. JAK1 is also necessary for the efficient phophorylation of Stat2 (p113) in response to IFN-alpha and for the phosphorylation of Tyk2 or JAK2 in response to IFNs-alpha or IFN-gamma, respectively.
Molecular Weight 130 kDa
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway

Application Details

Product Details anti-JAK1 Antibody Target Details JAK1 Handling References for anti-JAK1 Antibody (ABIN967842) Images back to top
Comment

Related Products: ABIN968537, ABIN967389

Restrictions For Research Use only

Handling

Product Details anti-JAK1 Antibody Target Details JAK1 Application Details References for anti-JAK1 Antibody (ABIN967842) Images back to top
Format Liquid
Concentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store undiluted at -20°C.

References for anti-JAK1 Antibody (ABIN967842)

Product Details anti-JAK1 Antibody Target Details JAK1 Application Details Handling Images back to top
Product cited in:

Kopantzev, Heller, Swaminathan, Rudikoff: "IL-6 mediated activation of STAT3 bypasses Janus kinases in terminally differentiated B lineage cells." in: Oncogene, Vol. 21, Issue 44, pp. 6791-800, 2002

Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: "Regulation of STAT protein synthesis by c-Cbl." in: Oncogene, Vol. 20, Issue 50, pp. 7326-33, 2001

Kawazoe, Naka, Fujimoto, Kohzaki, Morita, Narazaki, Okumura, Saitoh, Nakagawa, Uchiyama, Akira, Kishimoto: "Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation." in: The Journal of experimental medicine, Vol. 193, Issue 2, pp. 263-9, 2001

Müller, Briscoe, Laxton, Guschin, Ziemiecki, Silvennoinen, Harpur, Barbieri, Witthuhn, Schindler: "The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction." in: Nature, Vol. 366, Issue 6451, pp. 129-35, 1993

Background publications

Nicholson, Oates, Harpur, Ziemiecki, Wilks, Layton: "Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 8, pp. 2985-8, 1994

Images

Product Details anti-JAK1 Antibody Target Details JAK1 Application Details Handling References for anti-JAK1 Antibody (ABIN967842) back to top
Supplier Images
Western Blotting (WB) image for anti-JAK1 antibody (Janus Kinase 1) (AA 551-766) (ABIN967842) Western blot analysis of JAK1 on Jurkat cell lysate. Lane 1: 1:250, lane 2: 1:500, la...
Immunofluorescence (IF) image for anti-JAK1 antibody (Janus Kinase 1) (AA 551-766) (ABIN967842) Immunofluorescent staining of Human Endothelial cells.
 image for anti-JAK1 antibody (Janus Kinase 1) (AA 551-766) (ABIN967842) anti-Janus Kinase 1 (JAK1) (AA 551-766) antibody (Image 3)