anti-Human JAK1 antibody for Enzyme Immunoassay

Recommended JAK1 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 1 (JAK1) Antibodies
  • JNK
  • JNK1
  • JAK1
  • jak1
  • JAK1A
  • JAK1B
  • JTK3
  • AA960307
  • C130039L05Rik
  • wu:fb93e10
  • Janus kinase 1
  • mitogen-activated protein kinase 8
  • Tyrosine-protein kinase Jak1
  • JAK1
  • MAPK8
  • jak1
  • Jak1
Epitope
pTyr1022
29
21
18
16
15
15
7
7
4
4
3
3
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
138
111
95
6
6
4
4
2
Host
Rabbit
116
24
11
1
Clonality
Polyclonal
Conjugate
This JAK1 antibody is un-conjugated
4
4
4
4
4
4
4
3
3
3
2
2
2
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
92
66
48
25
13
12
12
11
7
4
2
2
Supplier
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Catalog No. ABIN318055
$ 390.50
Plus shipping costs $45.00

General

Antigen Janus Kinase 1 (JAK1) Antibodies
Epitope pTyr1022
(29), (21), (18), (16), (15), (15), (7), (7), (4), (4), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(138), (111), (95), (6), (6), (4), (4), (2)
Host Rabbit
(116), (24), (11), (1)
Clonality
Polyclonal
Conjugate This JAK1 antibody is un-conjugated
(4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(92), (66), (48), (25), (13), (12), (12), (11), (7), (4), (2), (2)
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Product Details anti-JAK1 Antibody

Target Details JAK1 Application Details Handling Images
Specificity This antibody detects endogenous levels of JAK1 pTyr1022 protein.
Purification Affinity Chromatography using epitope-specific immunogen.

Target Details JAK1

Product Details anti-JAK1 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tyrosine-Protein Kinase JAK1 (JAK1 Antibody Abstract)
Background JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.Synonyms: JAK-1, JAK1A, JAK1B, Janus kinase 1
Molecular Weight approx. 132 kDa
Gene ID 3716
NCBI Accession NP_002218
UniProt P23458
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Hepatitis C, Toll-Like Receptors Cascades, Unfolded protein response

Application Details

Product Details anti-JAK1 Antibody Target Details JAK1 Handling Images back to top
Application Notes ELISA: 1/10000-1/20000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-JAK1 Antibody Target Details JAK1 Application Details Images back to top
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-JAK1 Antibody Target Details JAK1 Application Details Handling back to top
Supplier Images
 image for anti-Janus Kinase 1 (JAK1) (pTyr1022) antibody (ABIN318055) anti-Janus Kinase 1 (JAK1) (pTyr1022) antibody