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anti-Human JAK2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended JAK2 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 2 (JAK2) Antibodies
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • jak2
  • JAK2bCA
  • JTK10
  • THCYT3
Epitope
pTyr1007
45
27
18
17
13
12
11
11
9
8
7
7
5
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
239
158
147
8
7
6
6
2
1
1
1
Host
Rabbit
235
14
5
Clonality
Polyclonal
Conjugate
This JAK2 antibody is un-conjugated
9
6
6
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
168
110
96
29
25
23
17
9
5
4
3
3
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Catalog No. ABIN196872
$ 357.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008982679 ABIN265487 IHC (p) WB Rabbit Log in to see Polyclonal
0.0008982679 ABIN3044228 IHC (p) WB Rabbit IgG AA 1096-1113, C-Term Log in to see Polyclonal
0.0008982679 ABIN189473 DB ICC IHC (fro) IF IHC (p) IP IHC WB Rabbit IgG Tyr1007, Tyr1008 Log in to see E132
0.0008982679 ABIN2854944 ICC IF IHC (p) WB Rabbit IgG N-Term Log in to see Polyclonal
0.0008982679 ABIN729688 IF (p) IHC (p) WB Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008982679 ABIN318056 EIA IHC (p) Rabbit pTyr1007 Log in to see Polyclonal
0.0008982679 ABIN1027308 IHC (p) Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN1027307 IHC (p) Rabbit IgG Log in to see Polyclonal
0.0008982679 ABIN319397 IHC (p) Rabbit Tyr570 Log in to see Polyclonal
0.0008982679 ABIN439657 ICC IF IHC IHC (p) IP WB Rabbit IgG AA 1082-1132 Log in to see Polyclonal
0.0008982679 ABIN729690 IHC (p) WB Biotin Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008982679 ABIN729697 IHC (p) WB HRP Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008982679 ABIN1176451 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 508-800 Log in to see Polyclonal
0.0008982679 ABIN740957 IHC (p) WB Biotin Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008982679 ABIN740964 IHC (p) WB HRP Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008982679 ABIN742853 IF (p) IHC (p) WB Rabbit IgG pTyr221 Log in to see Polyclonal
0.0008982679 ABIN740955 IF (p) IHC (p) WB Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008982679 ABIN4327879 IHC IHC (p) WB Rabbit pTyr1007 Log in to see Polyclonal
0.0008982679 ABIN4327885 ELISA ICC IF IHC IHC (p) WB Rabbit C-Term Log in to see Polyclonal
0.0008982679 ABIN2140338 IHC (p) WB Rabbit IgG C-Term Log in to see Polyclonal

Similar anti-JAK2 Antibodies

Application / Reactivity Human
Dot Blot (DB) 1 Antibodies
ELISA 87 Antibodies
Enzyme Immunoassay (EIA) 3 Antibodies
Flow Cytometry (FACS) 9 Antibodies
Immunochromatography (IC) 3 Antibodies
Immunocytochemistry (ICC) 15 Antibodies
Immunofluorescence (IF) 27 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies
Immunohistochemistry (IHC) 108 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 2 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 27 Antibodies
Immunoprecipitation (IP) 5 Antibodies
Western Blotting (WB) 159 Antibodies

General

Antigen Janus Kinase 2 (JAK2) Antibodies
Epitope pTyr1007
(45), (27), (18), (17), (13), (12), (11), (11), (9), (8), (7), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human
(239), (158), (147), (8), (7), (6), (6), (2), (1), (1), (1)
Host Rabbit
(235), (14), (5)
Clonality
Polyclonal
Conjugate This JAK2 antibody is un-conjugated
(9), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(168), (110), (96), (29), (25), (23), (17), (9), (5), (4), (3), (3)
Pubmed 4 references available
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Product Details anti-JAK2 Antibody

Target Details JAK2 Application Details Handling References for anti-JAK2 Antibody (ABIN196872) Images
Specificity The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatogramphy using non-phosphopeptide corresponding to the phosphorylation site. JAK2 (phospho-Tyr1007) antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 1007.
Purification Immunoaffinity chromatography.
Immunogen The antiserum was produced against synthesized phosphopeptide derived from human JAK2 around the phosphorylation site of tyrosine 1007 (K-E-YP-Y-K).

Target Details JAK2

Product Details anti-JAK2 Antibody Application Details Handling References for anti-JAK2 Antibody (ABIN196872) Images back to top
Antigen
Alternative Name Tyrosine-Protein Kinase JAK2 (JAK2 Antibody Abstract)
Background Synonyms: JAK-2, Janus kinase 2
Gene ID 3717
NCBI Accession NP_004963
UniProt O60674
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway

Application Details

Product Details anti-JAK2 Antibody Target Details JAK2 Handling References for anti-JAK2 Antibody (ABIN196872) Images back to top
Application Notes Suitable for use in Immunohistochemistry (1: 50approx. 1: 100).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details References for anti-JAK2 Antibody (ABIN196872) Images back to top
Concentration 1.0 mg/mL
Buffer PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store the antibody (in aliquots) at -20 °C.

References for anti-JAK2 Antibody (ABIN196872)

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling Images back to top
Background publications

James, Ugo, Le Couédic, Staerk, Delhommeau, Lacout, Garçon, Raslova, Berger, Bennaceur-Griscelli, Villeval, Constantinescu, Casadevall, Vainchenker: "A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera." in: Nature, Vol. 434, Issue 7037, pp. 1144-8, 2005

Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: "Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity." in: Molecular and cellular biology, Vol. 24, Issue 11, pp. 4955-67, 2004

Ungureanu, Saharinen, Junttila, Hilton, Silvennoinen: "Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1." in: Molecular and cellular biology, Vol. 22, Issue 10, pp. 3316-26, 2002

Xie, Wang, Liu, Sun, Wilson, Smithgall, Arlinghaus: "Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation." in: Oncogene, Vol. 20, Issue 43, pp. 6188-95, 2001

Images

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling References for anti-JAK2 Antibody (ABIN196872) back to top
Supplier Images
 image for anti-JAK2 antibody (Janus Kinase 2) (pTyr1007) (ABIN196872) anti-Janus Kinase 2 (JAK2) (pTyr1007) antibody