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|Antigen||Janus Kinase 2 (JAK2) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This JAK2 antibody is un-conjugated Alternatives|
Enzyme Immunoassay (EIA), Western Blotting (WB)
|1 reference available|
|Supplier||Log in to see|
Product Details anti-JAK2 AntibodyTarget Details JAK2 Application Details Handling References for anti-JAK2 antibody (ABIN356677) Images
|Specificity||This antibody is specific to JAK2 (C-term).|
|Purification||Protein G Chromatography, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Immunogen||This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human JAK2.|
Target Details JAK2Product Details anti-JAK2 Antibody Application Details Handling References for anti-JAK2 antibody (ABIN356677) Images back to top
|Alternative Name||Tyrosine-Protein Kinase JAK2 (JAK2 Antibody Abstract)|
|Background||This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.Synonyms: JAK-2, Janus kinase 2|
|Gene ID||3717, 9606|
|Research Area||Signaling, Cytokines, Receptors, Kinases/Phosphatases|
|Pathways||JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded protein response|
Application DetailsProduct Details anti-JAK2 Antibody Target Details JAK2 Handling References for anti-JAK2 antibody (ABIN356677) Images back to top
ELISA: 1/1,000. Western Blot: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
|Restrictions||For Research Use only|
HandlingProduct Details anti-JAK2 Antibody Target Details JAK2 Application Details References for anti-JAK2 antibody (ABIN356677) Images back to top
|Buffer||PBS containing 0.09 % (W/V) Sodium Azide as preservative.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Avoid repeated freezing and thawing.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.|
References for anti-JAK2 antibody (ABIN356677)Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling Images back to top
Kanda, Watanabe: "Prolactin enhances interferon-gamma-induced production of CXC ligand 9 (CXCL9), CXCL10, and CXCL11 in human keratinocytes." in: Endocrinology, Vol. 148, Issue 5, pp. 2317-25, 2007
ImagesProduct Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling References for anti-JAK2 antibody (ABIN356677) back to top