anti-Rat (Rattus) JAK2 antibody for Enzyme Immunoassay

Recommended JAK2 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 2 (JAK2) Antibodies
  • JAK2bCA
  • jak2
  • JTK10
  • THCYT3
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • Janus kinase 2b
  • Janus kinase 2
  • tyrosine-protein kinase JAK2-like
  • jak2b
  • JAK2
  • Jak2
  • LOC100051487
Epitope
pTyr1007
46
28
19
18
15
13
13
12
10
9
8
7
7
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
274
160
148
8
6
6
6
2
1
1
Host
Rabbit
263
22
5
Clonality
Polyclonal
Conjugate
This JAK2 antibody is un-conjugated
11
8
6
3
3
2
2
2
2
2
2
2
2
2
2
2
2
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
192
124
106
28
27
27
20
15
12
9
6
3
2
Supplier
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Catalog No. ABIN318056
$ 390.50
Plus shipping costs $45.00

General

Antigen Janus Kinase 2 (JAK2) Antibodies
Epitope pTyr1007
(46), (28), (19), (18), (15), (13), (13), (12), (10), (9), (8), (7), (7), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(274), (160), (148), (8), (6), (6), (6), (2), (1), (1)
Host Rabbit
(263), (22), (5)
Clonality
Polyclonal
Conjugate This JAK2 antibody is un-conjugated
(11), (8), (6), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1)
Application Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(192), (124), (106), (28), (27), (27), (20), (15), (12), (9), (6), (3), (2)
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Product Details anti-JAK2 Antibody

Target Details JAK2 Application Details Handling Images
Specificity This antibody detects endogenous levels of JAK2 pTyr1007 protein.
Purification Affinity Chromatography using epitope-specific immunogen.

Target Details JAK2

Product Details anti-JAK2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tyrosine-Protein Kinase JAK2 (JAK2 Antibody Abstract)
Background JAK2 (Janus Kinase 2) belongs to the emerging family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK2. JAK2 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to CIS elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies. Within the JAK2 kinase domain, there is a region that has considerable sequence homology to the regulatory region of the insulin receptor. Among a variety of sites, Tyrosines 1007 and 1008 are sites of trans- or autophosphorylation in vivo and in in vitro kinase reactions.Synonyms: JAK-2, Janus kinase 2
Gene ID 3717
NCBI Accession NP_004963
UniProt O60674
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway, Positive Regulation of Peptide Hormone Secretion, Intracellular Steroid Hormone Receptor Signaling Pathway, Response to Growth Hormone Stimulus, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling, Unfolded protein response

Application Details

Product Details anti-JAK2 Antibody Target Details JAK2 Handling Images back to top
Application Notes ELISA: 1/20000-1/40000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Images back to top
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling back to top
Supplier Images
 image for anti-Janus Kinase 2 (JAK2) (pTyr1007) antibody (ABIN318056) anti-Janus Kinase 2 (JAK2) (pTyr1007) antibody