You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Rat (Rattus) JAK2 antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended JAK2 Antibody (supplied by: Log in to see )

Antigen
Janus Kinase 2 (JAK2) Antibodies
  • AI504024
  • C81284
  • Fd17
  • JAK-2
  • jak2
  • JAK2bCA
  • JTK10
  • THCYT3
Epitope
AA 623-666
46
27
18
17
12
12
11
11
9
8
7
7
5
4
4
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
239
157
146
8
7
6
6
2
1
1
1
Host
Rabbit
235
14
5
Clonality
Polyclonal
Conjugate
This JAK2 antibody is un-conjugated
9
6
6
2
2
2
2
2
2
2
2
2
2
2
2
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
167
110
96
29
25
22
17
9
5
4
3
3
Supplier
Log in to see
Supplier Product No.
Log in to see
Request

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Available images

Catalog No. ABIN729688
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.0008846439 ABIN903220 IF (p) Alexa Fluor 555 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN903219 IF (p) Alexa Fluor 488 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN903218 IF (p) Alexa Fluor 647 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN903222 IF (p) Alexa Fluor 350 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN729692 IF (p) Cy5 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN729691 IF (p) Cy3 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN729693 IF (p) Cy5.5 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN729694 IF (p) Cy7 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN729695 IF (p) FITC Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN2803448 IF (p) Alexa Fluor 594 Rabbit IgG AA 623-666 Log in to see Polyclonal
0.0008846439 ABIN878635 IF (p) Alexa Fluor 488 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN878638 IF (p) Alexa Fluor 350 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN878639 IF (p) Alexa Fluor 555 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN878636 IF (p) Alexa Fluor 647 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN740958 IF (p) Cy3 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN740961 IF (p) Cy7 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN740959 IF (p) Cy5 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN740960 IF (p) Cy5.5 Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN740962 IF (p) FITC Rabbit IgG pTyr1007, pTyr1008 Log in to see Polyclonal
0.0008846439 ABIN742853 IF (p) IHC (p) WB Rabbit IgG pTyr221 Log in to see Polyclonal

Similar anti-JAK2 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
Dot Blot (DB) 1 Antibodies 1 Antibodies
ELISA 43 Antibodies 47 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies 2 Antibodies
Immunochromatography (IC) 1 Antibodies 1 Antibodies
Immunocytochemistry (ICC) 13 Antibodies 15 Antibodies
Immunofluorescence (IF) 14 Antibodies 20 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 77 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 3 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 17 Antibodies
Immunoprecipitation (IP) 3 Antibodies
Western Blotting (WB) 87 Antibodies
Flow Cytometry (FACS) 3 Antibodies

General

Antigen Janus Kinase 2 (JAK2) Antibodies
Epitope AA 623-666
(46), (27), (18), (17), (12), (12), (11), (11), (9), (8), (7), (7), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(239), (157), (146), (8), (7), (6), (6), (2), (1), (1), (1)
Host Rabbit
(235), (14), (5)
Clonality
Polyclonal
Conjugate This JAK2 antibody is un-conjugated
(9), (6), (6), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(167), (110), (96), (29), (25), (22), (17), (9), (5), (4), (3), (3)
Supplier Log in to see

Product Details anti-JAK2 Antibody

Target Details JAK2 Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human JAK2
Isotype IgG

Target Details JAK2

Product Details anti-JAK2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name JAK2 (JAK2 Antibody Abstract)
Background

Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO), or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recruited to the receptor. Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2. Once activated, dimerized STAT5 translocates into the nucleus and promotes the transcription of several essential genes involved in the modulation of erythropoiesis. In addition, JAK2 mediates angiotensin-2-induced ARHGEF1 phosphorylation. Plays a role in cell cycle by phosphorylating CDKN1B. Cooperates with TEC through reciprocal phosphorylation to mediate cytokine-driven activation of FOS transcription. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.

Subcellular location: Cytoplasm, Nucleus, Cell membrane


Synonyms: JTK1, THCYT3, Tyrosine-protein kinase JAK2, Janus kinase 2, JAK-2, JAK2
Gene ID 3717
UniProt O60674
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling, Interferon-gamma Pathway

Application Details

Product Details anti-JAK2 Antibody Target Details JAK2 Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-JAK2 Antibody Target Details JAK2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-JAK2 antibody (Janus Kinase 2) (AA 623-666) (ABIN729688) Formalin-fixed and paraffin embedded rat kidney tissue with labeled Anti-JAK2 Polyclo...
Flow Cytometry (FACS) image for anti-JAK2 antibody (Janus Kinase 2) (AA 623-666) (ABIN729688) Mouse splenocytes probed with Rabbit Anti-JAK2 Polyclonal Antibody, Unconjugated .