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|Application / Reactivity||Mouse (Murine)||Human|
|ELISA||14 Antibodies||35 Antibodies|
|Enzyme Immunoassay (EIA)||1 Antibodies||1 Antibodies|
|Flow Cytometry (FACS)||4 Antibodies||7 Antibodies|
|Immunochromatography (IC)||1 Antibodies||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies||5 Antibodies|
|Immunofluorescence (IF)||12 Antibodies||14 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||24 Antibodies|
|Immunohistochemistry (IHC)||11 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||10 Antibodies|
|Immunoprecipitation (IP)||1 Antibodies|
|Western Blotting (WB)||34 Antibodies|
|ELISA (Capture)||1 Antibodies|
|Antigen||Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies|
|Reactivity||Human, Mouse (Murine) Alternatives|
|Conjugate||This JAK3 antibody is un-conjugated Alternatives|
Immunocytochemistry (ICC), Flow Cytometry (FACS), ELISA, Western Blotting (WB)
|3 references available|
|Supplier||Log in to see|
Product Details anti-JAK3 AntibodyTarget Details JAK3 Application Details Handling References for anti-JAK3 Antibody (ABIN969224) Images
|Immunogen||Purified recombinant fragment of human JAK3 expressed in E. coli.|
Target Details JAK3Product Details anti-JAK3 Antibody Application Details Handling References for anti-JAK3 Antibody (ABIN969224) Images back to top
|Alternative Name||JAK3 (JAK3 Antibody Abstract)|
|Background||JAK3, Janus kinase 3. It is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease).|
|Molecular Weight||125 kDa|
|Research Area||Signaling, Cytokines, Receptors, Kinases/Phosphatases|
|Pathways||JAK-STAT Signaling, RTK Signaling|
Application DetailsProduct Details anti-JAK3 Antibody Target Details JAK3 Handling References for anti-JAK3 Antibody (ABIN969224) Images back to top
ELISA: 1/10000, WB: 1/500 - 1/2000, ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
|Restrictions||For Research Use only|
HandlingProduct Details anti-JAK3 Antibody Target Details JAK3 Application Details References for anti-JAK3 Antibody (ABIN969224) Images back to top
|Buffer||Ascitic fluid containing 0.03 % sodium azide.|
|Precaution of Use||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage||4 °C/-20 °C|
|Storage Comment||Store at 4 °C or at -20 °C for long term.|
References for anti-JAK3 Antibody (ABIN969224)Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling Images back to top
|Product cited in:||
Wood, Goodman, Uckun: "Jak3 expression and genomic sequence in pediatric acute lymphoblastic leukemia." in: Leukemia & lymphoma, Vol. 43, Issue 12, pp. 2355-62, 2003 (PubMed).
Kawamura, McVicar, Johnston et al.: "Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 14, pp. 6374-8, 1994 (PubMed).
Lai, Jin, Graham et al.: "A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells." in: The Journal of biological chemistry, Vol. 270, Issue 42, pp. 25028-36, 1995 (PubMed).
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