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anti-Mouse (Murine) JAK3 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended JAK3 Antibody (supplied by: Log in to see )

Antigen
Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
  • fae
  • JAK
  • JAK-3
  • JAK3_HUMAN
  • JAKL
  • L-JAK
  • LJAK
  • RATJAK3
  • wil
Reactivity
Human, Mouse (Murine), Rat (Rattus)
79
55
39
2
2
2
2
1
1
1
Host
Rabbit
61
22
Clonality
Polyclonal
Conjugate
This JAK3 antibody is un-conjugated
3
3
3
2
2
2
2
2
2
2
2
2
1
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
47
36
23
12
10
9
7
5
2
1
1
1
1
Supplier
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Catalog No. ABIN498150
$ 390.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00089488085 ABIN681013 IF (p) IHC (p) WB Rabbit IgG AA 610-660 Log in to see Polyclonal
0.00089488085 ABIN742883 IF (p) IHC (p) WB Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.00089488085 ABIN742892 IHC (p) WB HRP Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.00089488085 ABIN742885 IHC (p) WB Biotin Rabbit IgG pTyr980, pTyr981, AA 971-990 Log in to see Polyclonal
0.00089488085 ABIN1859525 ICC IHC (fro) IHC (p) ELISA WB Rabbit IgG AA 517-749 Log in to see Polyclonal
0.00089488085 ABIN681015 IHC (p) WB Biotin Rabbit IgG AA 610-660 Log in to see Polyclonal
0.00089488085 ABIN681022 IHC (p) WB HRP Rabbit IgG AA 610-660 Log in to see Polyclonal
0.00089488085 ABIN446756 ICC IF IHC (p) IHC WB Rabbit Log in to see Polyclonal
0.00089488085 ABIN742868 IF (p) IHC (p) WB Rabbit IgG pTyr785 Log in to see Polyclonal

Similar anti-JAK3 Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine)
ELISA 9 Antibodies 14 Antibodies
Immunocytochemistry (ICC) 1 Antibodies 5 Antibodies
Immunofluorescence (IF) 6 Antibodies 12 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 23 Antibodies 23 Antibodies
Immunohistochemistry (IHC) 9 Antibodies 11 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 9 Antibodies 10 Antibodies
Western Blotting (WB) 21 Antibodies
Enzyme Immunoassay (EIA) 1 Antibodies
Flow Cytometry (FACS) 4 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunoprecipitation (IP) 1 Antibodies

General

Antigen Tyrosine-Protein Kinase JAK3 (JAK3) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(79), (55), (39), (2), (2), (2), (2), (1), (1), (1)
Host Rabbit
(61), (22)
Clonality
Polyclonal
Conjugate This JAK3 antibody is un-conjugated
(3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(47), (36), (23), (12), (10), (9), (7), (5), (2), (1), (1), (1), (1)
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Product Details anti-JAK3 Antibody

Target Details JAK3 Application Details Handling Images
Specificity This antibody detects endogenous levels of JAK3 protein.
Cross-Reactivity (Details) Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
Purification Affinity chromatography using epitope-specific immunogen
Purity > 95 % (by SDS-PAGE)

Target Details JAK3

Product Details anti-JAK3 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tyrosine-Protein Kinase JAK3 (JAK3 Antibody Abstract)
Background Jak3 (Janus Kinase 3) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK3. JAK3 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. The canonical JAK/Stat pathway is integral to maintaining a normal immune system, stimulating proliferation, differentiation, survival and host resistance to pathogens. Altering JAK/Stat signaling to reduce cytokine induced pro-inflammatory responses represents an attractive target for anti-inflammatory therapies.Synonyms: JAK-3, Janus kinase 3, L-JAK, Leukocyte janus kinase
Molecular Weight approx. 125 kDa
Gene ID 3718
NCBI Accession NP_000206
UniProt P52333
Research Area Signaling, Cytokines, Receptors, Kinases/Phosphatases
Pathways JAK-STAT Signaling, RTK Signaling

Application Details

Product Details anti-JAK3 Antibody Target Details JAK3 Handling Images back to top
Application Notes Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Images back to top
Concentration 1.0 mg/mL
Buffer Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.

Images

Product Details anti-JAK3 Antibody Target Details JAK3 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN498150) Immunohistochemistry analyzes of JAK3 antibody in paraffin-embedded human brai...
Western Blotting (WB) image for anti-JAK3 antibody (Tyrosine-Protein Kinase JAK3) (ABIN498150) Western blot (WB) analysis of JAK3 antibody  in extracts from hela a...