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|Application / Reactivity||Human|
|Blocking Antibody (Inhibition)||3 Antibodies|
|Cellular Assay (CA)||1 Antibodies|
|Dot Blot (DB)||1 Antibodies|
|ELISA (Capture)||3 Antibodies|
|ELISA (Detection)||3 Antibodies|
|Enzyme Immunoassay (EIA)||13 Antibodies|
|Flow Cytometry (FACS)||16 Antibodies|
|Immunoassay (IA)||7 Antibodies|
|Immunochromatography (IC)||15 Antibodies|
|Immunocytochemistry (ICC)||11 Antibodies|
|Immunofluorescence (IF)||40 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||59 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||44 Antibodies|
|Immunoprecipitation (IP)||19 Antibodies|
|Antigen||Leptin (LEP) Antibodies|
|Conjugate||This Leptin antibody is un-conjugated Alternatives|
|Supplier||Log in to see|
Product Details anti-Leptin AntibodyTarget Details Leptin Application Details Handling Images
|Specificity||This antibody detects human Leptin proteins.|
|Immunogen||Purified recombinant full length of human Leptin protein expressed in E.coli.|
Target Details LeptinProduct Details anti-Leptin Antibody Application Details Handling Images back to top
|Alternative Name||LEP (LEP Antibody Abstract)|
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Subunit structure: Interacts with SIGLEC6
Subcellular location: Secreted.
Sequence similarities: Belongs to the leptin family.
|Molecular Weight||16 kDa|
|Pathways||JAK-STAT Signaling, AMPK Signaling|
Application DetailsProduct Details anti-Leptin Antibody Target Details Leptin Handling Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-Leptin Antibody Target Details Leptin Application Details Images back to top
|Buffer||PBS (pH 7.4) containing with 0.02 % sodium azide and 50 % glycerol.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
ImagesProduct Details anti-Leptin Antibody Target Details Leptin Application Details Handling back to top