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anti-Human Leptin antibody for Multiplex Assay

Recommended Leptin Antibody (supplied by: Log in to see )

Antigen
Leptin (LEP) Antibodies
  • LEPD
  • OB
  • ob
  • obese
  • OBS
Reactivity
Human
440
151
131
18
3
1
1
Host
Mouse
349
242
20
8
4
Clonality
Monoclonal
Conjugate
This Leptin antibody is un-conjugated
66
25
19
13
9
9
7
6
6
6
6
6
6
6
6
6
6
6
6
5
5
3
3
3
3
3
3
2
2
Application
Multiplex Assay (MA)
445
411
69
57
39
33
26
25
17
17
16
13
10
7
5
3
3
3
3
2
1
1
1
1
1
1
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Catalog No. ABIN2665227
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Top referenced anti-Leptin antibody for Multiplex Assay

Similar anti-Leptin Antibodies

Application / Reactivity Human
Blocking Antibody (Inhibition) 3 Antibodies
Cellular Assay (CA) 1 Antibodies
Dot Blot (DB) 1 Antibodies
ELISA 337 Antibodies
ELISA (Capture) 3 Antibodies
ELISA (Detection) 3 Antibodies
Enzyme Immunoassay (EIA) 13 Antibodies
Flow Cytometry (FACS) 16 Antibodies
Immunoassay (IA) 7 Antibodies
Immunochromatography (IC) 15 Antibodies
Immunocytochemistry (ICC) 10 Antibodies
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Immunohistochemistry (IHC) 57 Antibodies
Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) 2 Antibodies
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Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 42 Antibodies
Immunoprecipitation (IP) 19 Antibodies
Immunostaining (ISt) 1 Antibodies

General

Antigen Leptin (LEP) Antibodies
Reactivity Human
(440), (151), (131), (18), (3), (1), (1)
Host Mouse
(349), (242), (20), (8), (4)
Clonality (Clone)
Monoclonal   ( )
Conjugate This Leptin antibody is un-conjugated
(66), (25), (19), (13), (9), (9), (7), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (6), (5), (5), (3), (3), (3), (3), (3), (3), (2), (2)
Application Multiplex Assay (MA)
(445), (411), (69), (57), (39), (33), (26), (25), (17), (17), (16), (13), (10), (7), (5), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1)
Pubmed 6 references available
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Product Details anti-Leptin Antibody

Target Details Leptin Application Details Handling References for anti-Leptin Antibody (ABIN2665227) Images
Purification The antibody was purified by affinity chromatography.
Clone M1905E01
Isotype IgG2a

Target Details Leptin

Product Details anti-Leptin Antibody Application Details Handling References for anti-Leptin Antibody (ABIN2665227) Images back to top
Antigen
Alternative Name Leptin (LEP Antibody Abstract)
Background Leptin is primarily synthesized from adipocytes and plays a major role in energy homeostasis and obesity. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, expression of the short form of the leptin receptor, Ob-Ra, is downregulated, and the individual may be unresponsive to leptin signals. Leptin has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, hematopoiesis, and wound healing.
Research Area Cardiovascular, Atherosclerosis, Hormones
Pathways JAK-STAT Signaling, AMPK Signaling

Application Details

Product Details anti-Leptin Antibody Target Details Leptin Handling References for anti-Leptin Antibody (ABIN2665227) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-Leptin Antibody Target Details Leptin Application Details References for anti-Leptin Antibody (ABIN2665227) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-Leptin Antibody (ABIN2665227)

Product Details anti-Leptin Antibody Target Details Leptin Application Details Handling Images back to top
Background publications

Sáinz, Barrenetxe, Moreno-Aliaga, Martínez: "Leptin resistance and diet-induced obesity: central and peripheral actions of leptin." in: Metabolism: clinical and experimental, Vol. 64, Issue 1, pp. 35-46, 2014

Andò, Barone, Giordano, Bonofiglio, Catalano: "The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression." in: Frontiers in oncology, Vol. 4, pp. 340, 2014

Upadhyay, Farr, Mantzoros: "The role of leptin in regulating bone metabolism." in: Metabolism: clinical and experimental, Vol. 64, Issue 1, pp. 105-13, 2014

Brennan, Mantzoros: "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications." in: Nature clinical practice. Endocrinology & metabolism, Vol. 2, Issue 6, pp. 318-27, 2006

Zhang, Basinski, Beals, Briggs, Churgay, Clawson, DiMarchi, Furman, Hale, Hsiung, Schoner, Smith, Zhang, Wery, Schevitz: "Crystal structure of the obese protein leptin-E100." in: Nature, Vol. 387, Issue 6629, pp. 206-9, 1997

Halaas, Gajiwala, Maffei, Cohen, Chait, Rabinowitz, Lallone, Burley, Friedman: "Weight-reducing effects of the plasma protein encoded by the obese gene." in: Science (New York, N.Y.), Vol. 269, Issue 5223, pp. 543-6, 1995

Images

Product Details anti-Leptin Antibody Target Details Leptin Application Details Handling References for anti-Leptin Antibody (ABIN2665227) back to top
Supplier Images
Western Blotting (WB) image for anti-Leptin antibody (LEP) (ABIN2665227) anti-Leptin (LEP) antibody