|Application / Reactivity||Human|
|Blocking Antibody (Inhibition)||3 Antibodies|
|Cellular Assay (CA)||1 Antibodies|
|Dot Blot (DB)||1 Antibodies|
|ELISA (Capture)||3 Antibodies|
|ELISA (Detection)||3 Antibodies|
|Enzyme Immunoassay (EIA)||13 Antibodies|
|Flow Cytometry (FACS)||16 Antibodies|
|Immunoassay (IA)||7 Antibodies|
|Immunochromatography (IC)||15 Antibodies|
|Immunocytochemistry (ICC)||10 Antibodies|
|Immunofluorescence (IF)||39 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||57 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||2 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||6 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||24 Antibodies|
|Immunoprecipitation (IP)||19 Antibodies|
|Immunostaining (ISt)||1 Antibodies|
|Antigen||Leptin (LEP) Antibodies|
|Conjugate||This Leptin antibody is un-conjugated Alternatives|
Multiplex Assay (MA)
|6 references available|
|Supplier||Log in to see|
Product Details anti-Leptin AntibodyTarget Details Leptin Application Details Handling References for anti-Leptin Antibody (ABIN2665227) Images
|Purification||The antibody was purified by affinity chromatography.|
Target Details LeptinProduct Details anti-Leptin Antibody Application Details Handling References for anti-Leptin Antibody (ABIN2665227) Images back to top
|Alternative Name||Leptin (LEP Antibody Abstract)|
|Background||Leptin is primarily synthesized from adipocytes and plays a major role in energy homeostasis and obesity. Leptin resistance has been proposed as a pathophysiological mechanism of obesity. In obese individuals, expression of the short form of the leptin receptor, Ob-Ra, is downregulated, and the individual may be unresponsive to leptin signals. Leptin has also been implicated in the regulation of reproduction, glucose homeostasis, bone formation, hematopoiesis, and wound healing.|
|Research Area||Cardiovascular, Atherosclerosis, Hormones|
|Pathways||JAK-STAT Signaling, AMPK Signaling|
Application DetailsProduct Details anti-Leptin Antibody Target Details Leptin Handling References for anti-Leptin Antibody (ABIN2665227) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-Leptin Antibody Target Details Leptin Application Details References for anti-Leptin Antibody (ABIN2665227) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-Leptin Antibody (ABIN2665227)Product Details anti-Leptin Antibody Target Details Leptin Application Details Handling Images back to top
Andò, Barone, Giordano et al.: "The Multifaceted Mechanism of Leptin Signaling within Tumor Microenvironment in Driving Breast Cancer Growth and Progression." in: Frontiers in oncology, Vol. 4, pp. 340, 2014 (PubMed).
Upadhyay, Farr, Mantzoros: "The role of leptin in regulating bone metabolism." in: Metabolism: clinical and experimental, Vol. 64, Issue 1, pp. 105-13, 2014 (PubMed).
Sáinz, Barrenetxe, Moreno-Aliaga et al.: "Leptin resistance and diet-induced obesity: central and peripheral actions of leptin." in: Metabolism: clinical and experimental, Vol. 64, Issue 1, pp. 35-46, 2014 (PubMed).
Brennan, Mantzoros: "Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications." in: Nature clinical practice. Endocrinology & metabolism, Vol. 2, Issue 6, pp. 318-27, 2006 (PubMed).
Zhang, Basinski, Beals et al.: "Crystal structure of the obese protein leptin-E100." in: Nature, Vol. 387, Issue 6629, pp. 206-9, 1997 (PubMed).
Halaas, Gajiwala, Maffei et al.: "Weight-reducing effects of the plasma protein encoded by the obese gene." in: Science (New York, N.Y.), Vol. 269, Issue 5223, pp. 543-6, 1995 (PubMed).
ImagesProduct Details anti-Leptin Antibody Target Details Leptin Application Details Handling References for anti-Leptin Antibody (ABIN2665227) back to top