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Browse our Leptin Proteins (LEP)

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Leptin Proteins (LEP)
On are 215 Leptin (LEP) Proteins from 20 different suppliers available. Additionally we are shipping Leptin Antibodies (515) and Leptin Kits (170) and many more products for this protein. A total of 936 Leptin products are currently listed.
LEPD, OB, obese, OBS
list all proteins Gene Name GeneID UniProt
LEP 16846 P41160
LEP 3952 P41159
LEP 25608 P50596

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Leptin Proteins (LEP) by Origin

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Top referenced Leptin Proteins

  1. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN1047336 : Zhang, Proenca, Maffei, Barone, Leopold, Friedman: Positional cloning of the mouse obese gene and its human homologue. in Nature 1994 (PubMed)
    Show all 4 references for ABIN1047336

  2. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN666843 : Anini, Brubaker: Role of leptin in the regulation of glucagon-like peptide-1 secretion. in Diabetes 2003 (PubMed)
    Show all 3 references for ABIN666843

  3. Mouse (Murine) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN667698 : Hyogo, Roy, Paigen, Cohen: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for ABIN667698

  4. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914 : Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006 (PubMed)

More Proteins for Leptin Interaction Partners

Mouse (Murine) Leptin (LEP) interaction partners

  1. recent data showing that diet-induced obesity mice may conserve a cellular and physiological response to endogenous leptin, highlights the need to redefine the concept of "leptin resistance"--{REVIEW]

  2. Leptin-deficient mice had lower cancellous bone volume and higher bone marrow adiposity.

  3. FABP4 (show FABP4 Proteins) reduced the expression of leptin, CPT-1 (show CPT1A Proteins) and AOX1 (show AOX1 Proteins) in mice adipocytes

  4. leptin deficiency results in sustained orexigenic stimulation, leading to increased water diffusion parameters

  5. These results suggest the possibility for a direct role for the PDE3B pathway in mediating leptin action in the hypothalamus.

  6. leptin activates the cGH gene in the presence of chPit-1alpha via several leptin-activated kinases

  7. Data suggest that both adipocyte and somatotrope leptin contribute to the metabolic homeostasis.

  8. Tau effects upon feeding behavior control are complex and involve interactions with a vast gene network, preventing hypothalamic leptin resistance.

  9. These data suggest that exogenous leptin may promote protection during sepsis, and downregulation of the insulin (show INS Proteins) levels and upregulation of corticosterone may be important mechanisms in the amelioration of LPS (show TLR4 Proteins)-induced ALI.

  10. Leptin induces expression of the neuropeptide cocaine- and amphetamine-regulated transcript (show CARTPT Proteins) (CART) in the granulosa cells (GCs (show UGCG Proteins)) of ovarian follicles both in vitro and in vivo.

Human Leptin (LEP) interaction partners

  1. In pre-obese and obese rheumatoid arthritis patients there is increased production of serum leptin.

  2. advanced glycation end-products levels were positively correlated with disease progression and with leptin

  3. anti-apoptotic effect mediated by MAPK (show MAPK1 Proteins) and PI3K (show PIK3CA Proteins) pathways

  4. Leptin level correlated with obesity and health related quality of life in patients with obstructive sleep apnea.

  5. Data suggest that levels of adipokines (adiponectin (show ADIPOQ Proteins) and leptin), in addition to fasting blood glucose, may serve as biomarkers in screening overweight women with gestational diabetes at high metabolic risk for diabetes type 2 in postpartum period.

  6. the overexpression of leptin in osteoporotic bone marrow stromal cells enhances their capacity to differentiate into osteoblasts and to form bone-like tissue

  7. The leptin, ObR (show LEPR Proteins) and aromatase (show CYP19A1 Proteins) protein expression levels were increased in lesions in the vaginal septum and were decreased in the intestine lesions

  8. Serum levels of leptin are independently associated with increased knee cartilage volume in knee osteoarthritis.

  9. In metabolically healthy and unhealthy obese patients, distribution of the G19G, G19A, and A19A genotypes of the LEP gene and G276G, G276T, and T276T genotypes of ADPN (show PNPLA3 Proteins) gene did not differ.

  10. At day 1 after acute ischemic stroke, serum leptin and leptin/adiponectin (show ADIPOQ Proteins) ratio were increased and inversely associated with stroke severity.

Pig (Porcine) Leptin (LEP) interaction partners

  1. A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.

  2. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  3. Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.

  4. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  5. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  6. Another funning discovery is ob-Rb (show LEPR Proteins) mRNA in porcine endometrium was mainly negative-regulated by leptin

  7. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance

  8. Leptin and leptin receptor (show LEPR Proteins) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

  9. The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.

  10. Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor (show LEPR Proteins) gene expression varies in the ovaries of pregnant and cyclic pigs.

Cow (Bovine) Leptin (LEP) interaction partners

  1. Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.

  2. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (show NPY Proteins) and insulin (show INS Proteins) signaling pathways.

  3. Leptin R25C genotype impacted most traits associated with fatness.

  4. The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.

  5. Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (show NPY Proteins)) release.

  6. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

  7. Results indicated that leptin R25C genotype impacted most traits associated with fatness whereas feeding zilpaterol for 21 d affected weight gain positively but impacted other variables negatively.

  8. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y (show NPY Proteins), leptin, and IGF-1 (show IGF1 Proteins) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

  9. The LEP, IGF2 and CCL2 (show CCL2 Proteins) genes showed allelic expression imbalance in liver, kidney and pituitary glands of Polish Holstein-Friesian bulls.

  10. The aim of the study was to determine by immunochemistry the expression of leptin, orexin A and orphanin FQ in the major salivary glands (parotid, submandibular and sublingual) of rat, sheep and cow.

Goat Leptin (LEP) interaction partners

  1. polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production

Rabbit Leptin (LEP) interaction partners

  1. study suggests that increased CSF (show CSF2 Proteins) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (show IGF1 Proteins) after traumatic brain injury, leads to accelerated fracture healing

  2. We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (show GHRL Proteins).

  3. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (show PPARG Proteins) and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.

Horse (Equine) Leptin (LEP) interaction partners

  1. Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.

  2. Plasma levels of leptin (as well as glucose, insulin, and growth hormone) are highly correlated with the duration of winter anovulatory phase.

  3. GHRL (show GHRL Proteins), LEP, ADIP (show SSX2IP Proteins), INS (show INS Proteins) and CORT (show CORT Proteins) concentrations were measured using radioimmunoassay

  4. positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares

Rhesus Monkey Leptin (LEP) interaction partners

  1. The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (show ADIPOQ Proteins), leptin, and resistin (show RETN Proteins) in a set of four chair-restraint habituated intact adult male rhesus monkeys.

  2. results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction

Leptin (LEP) Protein Profile

Protein Summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Alternative names and synonyms associated with Leptin (LEP)

  • leptin (Lep)
  • leptin (LEP)
  • leptin (lep)
  • LEPD protein
  • OB protein
  • obese protein
  • OBS protein

Protein level used designations for Leptin Proteins (LEP)

obesity factor , leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , obese protein , obese, mouse, homolog of , obese

16846 Mus musculus
3952 Homo sapiens
25608 Rattus norvegicus
443534 Ovis aries
396832 Sus scrofa
280836 Bos taurus
100860794 Capra hircus
100008747 Oryctolagus cuniculus
373955 Gallus gallus
403616 Canis lupus familiaris
100034042 Equus caballus
493838 Felis catus
449638 Pan troglodytes
100716751 Cavia porcellus
698728 Macaca mulatta
548631 Takifugu rubripes
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