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Browse our Leptin Proteins (LEP)

Full name:
Leptin Proteins (LEP)
On www.antibodies-online.com are 207 Leptin (LEP) Proteins from 20 different suppliers available. Additionally we are shipping Leptin Antibodies (599) and Leptin Kits (166) and many more products for this protein. A total of 1008 Leptin products are currently listed.
Synonyms:
LEPD, OB, obese, OBS
list all proteins Gene Name GeneID UniProt
LEP 16846 P41160
LEP 3952 P41159
LEP 25608 P50596

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Leptin Proteins (LEP) by Origin

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Top referenced Leptin Proteins

  1. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN1047336 : Zhang, Proenca, Maffei, Barone, Leopold, Friedman: Positional cloning of the mouse obese gene and its human homologue. in Nature 1994 (PubMed)
    Show all 4 references for ABIN1047336

  2. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN666843 : Anini, Brubaker: Role of leptin in the regulation of glucagon-like peptide-1 secretion. in Diabetes 2003 (PubMed)
    Show all 3 references for ABIN666843

  3. Mouse (Murine) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN667698 : Hyogo, Roy, Paigen, Cohen: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for ABIN667698

  4. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914 : Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006 (PubMed)

More Proteins for Leptin Interaction Partners

Mouse (Murine) Leptin (LEP) interaction partners

  1. geniposide may regulate tau phosphorylation through leptin signaling

  2. Activated FXR (show NR1H4 Proteins) inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy.

  3. this study shows that knockdown of leptin in hepatoma cells caused higher Treg activity and lower CD8 (show CD8A Proteins)+ T-cell response in the mouse hepatocellular carcinoma allograft model.

  4. Hexim1 (show HEXIM1 Proteins) selectively modulates leptin-mediated signal transduction pathways in the hypothalamus.

  5. The weight-reducing hypophagic effects of leptin are not augmented through its thermogenic effect.

  6. ime-specific changes in promoter associated DNA methyltransferases may be associated with the regulation of leptin expression.

  7. These data suggest that the heavy infiltration of adipocytes and the presence of leptin in the thymuses of tumor bearers may affect normal thymopoiesis, leading to the impairment of T cell development observed during tumor-induced thymic atrophy.

  8. Leptin resistance-induced obesity and diabetes accelerates the development of tau pathology

  9. Obese leptin-deficient (ob/ob) mice demonstrate defects in upper airway structural and neuromuscular control

  10. recent data showing that diet-induced obesity mice may conserve a cellular and physiological response to endogenous leptin, highlights the need to redefine the concept of "leptin resistance"--{REVIEW]

Human Leptin (LEP) interaction partners

  1. Study showed that adipokine leptin triggered macrophage- related cytokine IL-18 (show IL18 Proteins) production, possibly contributing to tumor progression in breast cancer cells.

  2. sebocyte-derived leptin may have a role in hyperseborrhea, ductal hypoxia, inflammation and comedogenesis in acne vulgaris [commentary]

  3. Genetic alterations in the leptin, LEPR and MC$R genes are associated with severe obesity.

  4. A higher degree of local tissue hypoxia and up-regulation of leptin expression in the perivascular adipose tissue, along with increased vascularization, inflammation, and fibrosis, may contribute to the increased atherosclerotic plaque burden in the coronary arteries compared to the internal mammary arteries.

  5. Effects of leptin and leptin receptor (show LEPR Proteins) SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.

  6. this study shows the role of LEP polymorphisms in the risk of multiple sclerosis and its severity in Iran

  7. Both leptin and ghrelin (show GHRL Proteins) used separately at the concentrations corresponding to trimesters II-III of pregnancy increase the number of CD56 (show NCAM1 Proteins)(bright) NK cells in mononuclear cell suspension; their combination also enhances the L-selectin (show SELL Proteins) expression on the surface of these cells in the culture. These hormones do not affect the production of TGF-beta1 (show TGFB1 Proteins), IL-17capital A, Cyrillic, or IFN-gamma (show IFNG Proteins) by NK cells, and they inhibit the ...

  8. leptin, resistin (show RETN Proteins), and obesity play important roles in the onset of preeclampsia; leptin and resistin (show RETN Proteins) may have some impacts on the fetal growth and development

  9. Asthma was associated with insulin (show INS Proteins) resistance and a systemic inflammatory response possibly mediated by adipokines, with leptin levels standing out among the participants with excess weight.

  10. maternal and neonatal LEP and LEPR polymorphisms are significantly associated with increased risk for preterm birth.

Pig (Porcine) Leptin (LEP) interaction partners

  1. A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.

  2. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  3. Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.

  4. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  5. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  6. Another funning discovery is ob-Rb (show LEPR Proteins) mRNA in porcine endometrium was mainly negative-regulated by leptin

  7. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance

  8. Leptin and leptin receptor (show LEPR Proteins) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

  9. The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.

  10. Locally produced leptin plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor (show LEPR Proteins) gene expression varies in the ovaries of pregnant and cyclic pigs.

Cow (Bovine) Leptin (LEP) interaction partners

  1. A leptin SNP (LEPg.978) was significantly associated with a weight at one year.

  2. The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.

  3. Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.

  4. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (show NPY Proteins) and insulin (show INS Proteins) signaling pathways.

  5. Leptin R25C genotype impacted most traits associated with fatness.

  6. The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.

  7. Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (show NPY Proteins)) release.

  8. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

  9. Results indicated that leptin R25C genotype impacted most traits associated with fatness whereas feeding zilpaterol for 21 d affected weight gain positively but impacted other variables negatively.

  10. There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y (show NPY Proteins), leptin, and IGF-1 (show IGF1 Proteins) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.

Goat Leptin (LEP) interaction partners

  1. polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production

Rabbit Leptin (LEP) interaction partners

  1. study suggests that increased CSF (show CSF2 Proteins) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (show IGF1 Proteins) after traumatic brain injury, leads to accelerated fracture healing

  2. We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (show GHRL Proteins).

  3. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (show PPARG Proteins) and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.

Horse (Equine) Leptin (LEP) interaction partners

  1. Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.

  2. Plasma levels of leptin (as well as glucose, insulin (show INS Proteins), and growth hormone (show GH1 Proteins)) are highly correlated with the duration of winter anovulatory phase.

  3. GHRL (show GHRL Proteins), LEP, ADIP (show SSX2IP Proteins), INS (show INS Proteins) and CORT (show CORT Proteins) concentrations were measured using radioimmunoassay

  4. positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares

Rhesus Monkey Leptin (LEP) interaction partners

  1. The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (show ADIPOQ Proteins), leptin, and resistin (show RETN Proteins) in a set of four chair-restraint habituated intact adult male rhesus monkeys.

  2. results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction

Leptin (LEP) Protein Profile

Protein Summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Alternative names and synonyms associated with Leptin (LEP)

  • leptin (Lep)
  • leptin (LEP)
  • leptin (lep)
  • LEPD protein
  • OB protein
  • obese protein
  • OBS protein

Protein level used designations for Leptin Proteins (LEP)

obesity factor , leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , obese protein , obese, mouse, homolog of , obese

GENE ID SPECIES
16846 Mus musculus
3952 Homo sapiens
25608 Rattus norvegicus
443534 Ovis aries
396832 Sus scrofa
280836 Bos taurus
100860794 Capra hircus
100008747 Oryctolagus cuniculus
373955 Gallus gallus
403616 Canis lupus familiaris
100034042 Equus caballus
493838 Felis catus
449638 Pan troglodytes
100716751 Cavia porcellus
698728 Macaca mulatta
548631 Takifugu rubripes
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