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Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN1047336
Zhang, Proenca, Maffei, Barone, Leopold, Friedman: Positional cloning of the mouse obese gene and its human homologue. in Nature 1994
Show all 4 references for ABIN1047336
Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN666843
Anini, Brubaker: Role of leptin in the regulation of glucagon-like peptide-1 secretion. in Diabetes 2003
Show all 3 references for ABIN666843
Mouse (Murine) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN667698
Hyogo, Roy, Paigen, Cohen: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. in The Journal of biological chemistry 2002
Show all 3 references for ABIN667698
Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914
Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006
These findings suggest that by impairing the testicular LEP-JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway, early-stage obesity inhibits the biosynthesis of testosterone and sexual development and reduces male reproductive potential. Long-term moderate and high-volume exercise can effectively reduce body fat and improve obesity-induced abnormalities in testicular leptin signal transduction, whereas only moderate-volume exercise can reverse the negativ
genetic and pharmacological ablation of adult NG2 (show Vcan Proteins)-glia (also known as oligodendrocyte precursors), but not microglia, leads to primary leptin resistance and obesity in mice.
a novel mechanism of leptin-induced fatty acid oxidation in muscle tissue; namely, this process is dependent on the activation of AMPK (show PRKAA1 Proteins) to induce the translocation of FAT/CD36 (show CD36 Proteins) to the plasma membrane, thereby stimulating fatty acid uptake.
Results demonstrate that in white adipose tissue, leptin expression and secretion is promoted by Epac1 (show RAPGEF3 Proteins), hence regulating energy balance and glucose homeostasis.
may regulate growth hormone (show GH1 Proteins) expression in somatotropes through the stimulation of POU1F1 (show POU1F1 Proteins)
This study found that the expression of leptin and its receptor OB-R (show LEPR Proteins) in mouse models of Sjogren's syndrome are elevated both locally and systemically during Sjogren's syndrome progression.
obesity-associated elevation of leptin contributes to the increased susceptibility of asthma via modulation of pro-allergic lymphocyte responses.
Leptin stimulation led to TNFalpha (show TNF Proteins) production under both in vitro and in vivo conditions, and diurnal fluctuation of leptin concentrations in the cerebrospinal fluid predicted the circadian changes of TNFalpha (show TNF Proteins) gene expression in the hypothalamus.
geniposide may regulate tau phosphorylation through leptin signaling
Activated FXR (show NR1H4 Proteins) inhibits leptin signaling and counteracts tumor-promoting activities of cancer-associated fibroblasts in breast malignancy.
serum and lung adiponectin (show ADIPOQ Proteins), leptin, and resistin (show RETN Proteins) were measured in an atopic adult study population following exposure to allergen and diesel exhaust
Leptin -2548G/A polymorphism may play a role in male fertility and the AG genotype may have a protective effect by increasing sperm counts.
In the case of undernutrition, a decrease was observed in levels of leptin and in the lactonase activity (LAC (show LCT Proteins)) of paraoxonase, while adiponectin (show ADIPOQ Proteins) levels increased. Besides PINI, leptin was the only parameter that was independently related to undernutrition.
Serum leptin is strongly associated with obesity in Cameroon population.
Differences were found in the neonatal and maternal expression of leptin, adiponectin (show ADIPOQ Proteins), adropin (show ENHO Proteins), and endothelin-1 (show EDN1 Proteins) in intrauterine growth restricted mothers and neonates compared with a control group.
Leptin did not seem to be associated with IgE-mediated inflammation in atopic dermatitis. Obesity-associated high leptin differed between non-atopic atopic dermatitis and atopic atopic dermatitis subjects.
Plasma leptin was lowered in patients with systemic sclerosis.
Human CRP (show CRP Proteins) can impede the access of leptin to the CNS, and elevation of human CRP (show CRP Proteins) within the CNS can have a negative impact on the physiological actions of leptin.
In tissue samples, hypoxia-inducible factor 1-alpha (show HIF1A Proteins) messenger RNA and protein expression of leptin and leptin receptor (show LEPR Proteins) were high in oral squamous cell carcinoma cases. Serum leptin levels were increased in first clinical stages of the disease.
Leptin appears to be a predictor of body pain both within- and between-individuals and may be a driver of generalized pain states such as fibromyalgia.
The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.
A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.
The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.
Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.
These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.
Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.
Another funning discovery is ob-Rb (show LEPR Proteins) mRNA in porcine endometrium was mainly negative-regulated by leptin
Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance
Leptin and leptin receptor (show LEPR Proteins) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.
The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.
The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.
A leptin SNP (LEPg.978) was significantly associated with a weight at one year.
The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.
Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (show NPY Proteins) and insulin (show INS Proteins) signaling pathways.
Leptin R25C genotype impacted most traits associated with fatness.
The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (show NPY Proteins)) release.
SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only
Results indicated that leptin R25C genotype impacted most traits associated with fatness whereas feeding zilpaterol for 21 d affected weight gain positively but impacted other variables negatively.
polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production
study suggests that increased CSF (show CSF2 Proteins) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (show IGF1 Proteins) after traumatic brain injury, leads to accelerated fracture healing
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (show GHRL Proteins).
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (show PPARG Proteins) and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.
Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.
Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.
Plasma levels of leptin (as well as glucose, insulin (show INS Proteins), and growth hormone (show GH1 Proteins)) are highly correlated with the duration of winter anovulatory phase.
GHRL (show GHRL Proteins), LEP, ADIP (show SSX2IP Proteins), INS (show INS Proteins) and CORT (show CORT Proteins) concentrations were measured using radioimmunoassay
positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares
The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (show ADIPOQ Proteins), leptin, and resistin (show RETN Proteins) in a set of four chair-restraint habituated intact adult male rhesus monkeys.
results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction
This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
, leptin (murine obesity homolog)
, leptin (obesity homolog, mouse)
, obese protein
, obese, mouse, homolog of