Browse our Leptin Proteins (LEP)

Full name:
Leptin Proteins (LEP)
On www.antibodies-online.com are 199 Leptin (LEP) Proteins from 21 different suppliers available. Additionally we are shipping Leptin Antibodies (607) and Leptin Kits (192) and many more products for this protein. A total of 1035 Leptin products are currently listed.
Synonyms:
LEPD, OB, obese, OBS
list all proteins Gene Name GeneID UniProt
LEP 16846 P41160
LEP 3952 P41159
LEP 25608 P50596

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Leptin Proteins (LEP) by Origin

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Top referenced Leptin Proteins

  1. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN1047336 : Zhang, Proenca, Maffei, Barone, Leopold, Friedman: Positional cloning of the mouse obese gene and its human homologue. in Nature 1994 (PubMed)
    Show all 4 references for 1047336

  2. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803917 : Moon, Chamberland, Diakopoulos, Fiorenza, Ziemke, Schneider, Mantzoros: Leptin and amylin act in an additive manner to activate overlapping signaling pathways in peripheral tissues: in vitro and ex vivo studies in humans. in Diabetes Care 2011 (PubMed)
    Show all 3 references for 803917

  3. Human Leptin Protein expressed in Escherichia coli (E. coli) - ABIN666843 : Anini, Brubaker: Role of leptin in the regulation of glucagon-like peptide-1 secretion. in Diabetes 2003 (PubMed)
    Show all 3 references for 666843

  4. Mouse (Murine) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN667698 : Hyogo, Roy, Paigen, Cohen: Leptin promotes biliary cholesterol elimination during weight loss in ob/ob mice by regulating the enterohepatic circulation of bile salts. in The Journal of biological chemistry 2002 (PubMed)
    Show all 3 references for 667698

  5. Rat (Rattus) Leptin Protein expressed in Escherichia coli (E. coli) - ABIN803914 : Castellano, Navarro, Fernández-Fernández, Roa, Vigo, Pineda, Dieguez, Aguilar, Pinilla, Tena-Sempere: Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats. in Diabetes 2006 (PubMed)

More Proteins for Leptin Interaction Partners

Mouse (Murine) Leptin (LEP) interaction partners

  1. High fat diet attenuates leptin signaling throughout the brain, but some brain regions maintain their ability to sense leptin. Weight loss restores leptin sensing to some degree in most (but not all) brain regions, while other brain regions display hypersensitivity to leptin following weight loss

  2. CNS-specific Tak1 (show NR2C2 Proteins) deletion prevented ER-stress-induced hypothalamic leptin resistance and hyperphagic obesity under a high-fat diet (HFD). Thus, TAK1 (show NR2C2 Proteins) is a crucial regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.

  3. These data further implicate IL-6 (show IL6 Proteins) in fatty liver disease modulation in the context of DIO, and indicate that continuous stimulation with IL-6 (show IL6 Proteins) attenuates the IL-6 (show IL6 Proteins)-receptor response, which is associated with high serum levels of leptin.

  4. these data unmasked a role for mitochondrial fission in leptin sensitivity and glucose sensing of POMC (show POMC Proteins) neurons.

  5. Obesity and leptin deficiency substantially decreased morphine metabolism and clearance.

  6. These findings suggest that by impairing the testicular LEP-JAK (show JAK3 Proteins)-STAT (show STAT1 Proteins) pathway, early-stage obesity inhibits the biosynthesis of testosterone and sexual development and reduces male reproductive potential. Long-term moderate and high-volume exercise can effectively reduce body fat and improve obesity-induced abnormalities in testicular leptin signal transduction, whereas only moderate-volume exercise can reverse the negativ

  7. genetic and pharmacological ablation of adult NG2 (show Vcan Proteins)-glia (also known as oligodendrocyte precursors), but not microglia, leads to primary leptin resistance and obesity in mice.

  8. a novel mechanism of leptin-induced fatty acid oxidation in muscle tissue; namely, this process is dependent on the activation of AMPK (show PRKAA1 Proteins) to induce the translocation of FAT/CD36 (show CD36 Proteins) to the plasma membrane, thereby stimulating fatty acid uptake.

  9. Results demonstrate that in white adipose tissue, leptin expression and secretion is promoted by Epac1 (show RAPGEF3 Proteins), hence regulating energy balance and glucose homeostasis.

  10. may regulate growth hormone (show GH1 Proteins) expression in somatotropes through the stimulation of POU1F1 (show POU1F1 Proteins)

Human Leptin (LEP) interaction partners

  1. Leptin, at concentrations with minimal or no activating effects on astrocytoma cells, enhanced growth and migration promoted by low doses of sPLA2-IIA (show PLA2G2A Proteins). sPLA2-IIA (show PLA2G2A Proteins) alone induced a transient phosphorylation pattern in the Src (show SRC Proteins)/ERK (show EPHB2 Proteins)/Akt (show AKT1 Proteins)/mTOR (show FRAP1 Proteins)/p70S6K (show RPS6KB1 Proteins)/rS6 pathway through EGFR (show EGFR Proteins) transactivation

  2. a novel mechanism by which compromised HDLECs maintain their homeostasis during inflammation mediated by leptin and IL-6 (show IL6 Proteins)

  3. In this study of a predominantly minority population, no association between premorbid leptin levels and cancer incidence was demonstrated

  4. Centenarians had significant higher serum levels of leptin compared with controls (p<0.001), whereas no significant differences were observed for adiponectin (show ADIPOQ Proteins).

  5. Studies suggest that metformin treatment was not associated with a decrease in blood leptin levels, or increases in blood ghrelin (show GHRL Proteins) levels in patients with type 2 diabetes mellitus (T2DM).

  6. higher prediagnostic levels of plasma leptin were associated with an elevated risk of pancreatic cancer among men, but not among women

  7. Leptin levels are not significantly associated with incident atrial fibrillation in women.

  8. Results found an association between DNA methylation (show HELLS Proteins) in each CpG site of the gene LEP, measured in saliva (show RAG1AP1 Proteins), and obesity-related measures in 431 children aged 10- 15 years old. This association differed by sex and obesity status, with a much stronger association in obese boys.

  9. Data suggest caloric restriction modifies response of ovarian granulosa cells to leptin on cell proliferation/apoptosis, MAP kinase (show MAPK1 Proteins) signaling, and release of hormones (estradiol and IGFI (show IGF1 Proteins)). The caloric restriction studies were conducted in rabbits; then, isolated rabbit granulosa cells were exposed to recombinant human leptin. (IGF1 (show IGF1 Proteins) = insulin-like growth factor I (show IGF1 Proteins))

  10. Data suggest that modest weight loss in overweight adults due to caloric restriction and exercise decreases serum leptin (LEP) and high molecular weight adiponectin (ADPN), and increases serum pentraxin-3 (PTX3 (show PTX3 Proteins)) in a manner that correlates with increased insulin (show INS Proteins) sensitivity.

Pig (Porcine) Leptin (LEP) interaction partners

  1. The lack of effect of heat stress on the expression of leptin suggests that this peptide may not be involved in the reduction of feed intake of HS acclimated pigs.

  2. A high variability of the LEP was detected in the different analysed populations providing new data for the existence of two domestication centres in Asia.

  3. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  4. Studied 3'UTR leptin polymorphism regulatory sequences' affect on gene expression and their association with production traits.

  5. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  6. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  7. Another funning discovery is ob-Rb (show LEPR Proteins) mRNA in porcine endometrium was mainly negative-regulated by leptin

  8. Characterization of a distinctive pattern of periovulatory leptin secretion and its relationship with ovulation rate and luteal function in swine with obesity/leptin resistance

  9. Leptin and leptin receptor (show LEPR Proteins) are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin mRNA expression as well as E and P on leptin secretion by those cells obtained in early pregnancy.

  10. The present study aimed to determine the effects of breed and sex on growth patterns and metabolic features of advanced-pregnancy foetuses from lean and obese/leptin resistant swine.

Cow (Bovine) Leptin (LEP) interaction partners

  1. Consistent with this, leptin enhanced GnRH (show GNRH1 Proteins)-induced secretion of LH measured by ELISA. We suggest that leptin enhances membrane expression of voltage-gated Na(+) and Ca(2 (show CA2 Proteins)+) channels, which results in a modulation of the action potential properties and an increase in hormone release from gonadotropes.

  2. The effects of a single nucleotide polymorphism of leptin on weight gain and body composition are reported.

  3. A leptin SNP (LEPg.978) was significantly associated with a weight at one year.

  4. The results of this study suggest that leptin physiology could be a candidate for mechanisms that contribute to feed intake and feed efficiency variation in beef cattle.

  5. Leptin concentrations could be a useful physiological marker for growth and feed efficiency of finishing beef cattle.

  6. Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin-NPY (show NPY Proteins) and insulin (show INS Proteins) signaling pathways.

  7. Leptin R25C genotype impacted most traits associated with fatness.

  8. The absence of A80V polymorphism (C --> T at position 95691973 bp of leptin gene) has been established in the genotypes of Ayrshire cattle as compared to Holstein cattle.

  9. Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin and hypothalamic neuropeptide Y (NPY (show NPY Proteins)) release.

  10. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

Goat Leptin (LEP) interaction partners

  1. polymorphisms of the LEP gene might be important genetic factors influencing growth traits, and these genetic markers may be useful for future marker-assisted selection programs in goat breeding and production

Rabbit Leptin (LEP) interaction partners

  1. study suggests that increased CSF (show CSF2 Proteins) leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 (show IGF1 Proteins) after traumatic brain injury, leads to accelerated fracture healing

  2. We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin (show GHRL Proteins).

  3. Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma (show PPARG Proteins) and CD36 (show CD36 Proteins) mRNA expression in hypercholesterolemic rabbits.

Horse (Equine) Leptin (LEP) interaction partners

  1. Positive correlations were found between leptin and total lipids, triglycerides, VLDLs, Total-Chol, and LDLs.

  2. Leptin metabolism in obese ponies following a return to free feeding after a period of food deprivation is reported.

  3. Plasma levels of leptin (as well as glucose, insulin (show INS Proteins), and growth hormone (show GH1 Proteins)) are highly correlated with the duration of winter anovulatory phase.

  4. GHRL (show GHRL Proteins), LEP, ADIP (show SSX2IP Proteins), INS (show INS Proteins) and CORT (show CORT Proteins) concentrations were measured using radioimmunoassay

  5. positive correlation between leptin and estradiol led us to suggest that leptin hormone plays an important role in ovulation of the first postpartum estrus in mares

Rhesus Monkey Leptin (LEP) interaction partners

  1. The effects of exogenous human kisspeptin-10 (KP10) were studied on three important adipokines, namely, adiponectin (show ADIPOQ Proteins), leptin, and resistin (show RETN Proteins) in a set of four chair-restraint habituated intact adult male rhesus monkeys.

  2. results do not support a role for reduced leptin secretion in anovulation induced by dietary restriction

Leptin (LEP) Protein Profile

Protein Summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.

Alternative names and synonyms associated with Leptin (LEP)

  • leptin (Lep)
  • leptin (LEP)
  • leptin (lep)
  • LEPD protein
  • OB protein
  • obese protein
  • OBS protein

Protein level used designations for Leptin Proteins (LEP)

obesity factor , leptin (murine obesity homolog) , leptin (obesity homolog, mouse) , obese protein , obese, mouse, homolog of , obese

GENE ID SPECIES
16846 Mus musculus
3952 Homo sapiens
25608 Rattus norvegicus
443534 Ovis aries
396832 Sus scrofa
280836 Bos taurus
100860794 Capra hircus
100008747 Oryctolagus cuniculus
373955 Gallus gallus
403616 Canis lupus familiaris
100034042 Equus caballus
493838 Felis catus
449638 Pan troglodytes
100716751 Cavia porcellus
698728 Macaca mulatta
548631 Takifugu rubripes
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