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Browse our anti-Leptin Receptor (LEPR) Antibodies

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anti-Leptin Receptor Antibodies (LEPR)
On are 229 Leptin Receptor (LEPR) Antibodies from 32 different suppliers available. Additionally we are shipping Leptin Receptor Kits (66) and Leptin Receptor Proteins (25) and many more products for this protein. A total of 329 Leptin Receptor products are currently listed.
CD295, db, diabetes, Fa, LEP-R, LEPR, Leprb, LEPRD, LEPROT, Modb1, Ob-R, ob-rb, OB-RGRP, Ob-RM, obese-like, obl, Obr, ObRb, Obrgrp, VPS55

Most Popular Reactivities for anti-Leptin Receptor (LEPR) Antibodies

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anti-Human Leptin Receptor Antibodies:

anti-Mouse (Murine) Leptin Receptor Antibodies:

anti-Rat (Rattus) Leptin Receptor Antibodies:

All available anti-Leptin Receptor Antibodies

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Top referenced anti-Leptin Receptor Antibodies

  1. Cow (Bovine) Polyclonal Leptin Receptor Primary Antibody for IHC, ELISA - ABIN1582193 : Bigford, Bracchi-Ricard, Nash, Bethea: Alterations in mouse hypothalamic adipokine gene expression and leptin signaling following chronic spinal cord injury and with advanced age. in PLoS ONE 2012 (PubMed)
    Show all 3 references for ABIN1582193

  2. Human Monoclonal Leptin Receptor Primary Antibody for FACS, IHC - ABIN4899702 : Francois, Roper, Goodman, Pei, Ghumman, Mourad, de Perez, Perez-Perez, Tseng, Blaser: The association of gastric leptin with oesophageal inflammation and metaplasia. in Gut 2007 (PubMed)
    Show all 3 references for ABIN4899702

  3. Human Polyclonal Leptin Receptor Primary Antibody for WB - ABIN267340 : Liu, Samad, Mueller: Local adipocytes enable estrogen-dependent breast cancer growth: Role of leptin and aromatase. in Adipocyte 2013 (PubMed)
    Show all 2 references for ABIN267340

  4. Human Monoclonal Leptin Receptor Primary Antibody for FACS - ABIN4896545 : Carbone, De Rosa, Carrieri, Montella, Bruzzese, Porcellini, Procaccini, La Cava, Matarese: Regulatory T cell proliferative potential is impaired in human autoimmune disease. in Nature medicine 2014 (PubMed)

  5. Human Polyclonal Leptin Receptor Primary Antibody for IHC (p), ELISA - ABIN214683 : Unglaub, Wolf, Kroeber, Dragu, Schwarz, Mittlmeier, Kloeters, Horch: Expression of leptin, leptin receptor, and connective tissue growth factor in degenerative disk lesions in the wrist. in Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association 2011 (PubMed)

  6. Human Polyclonal Leptin Receptor Primary Antibody for ELISA, WB - ABIN251477 : Snoussi, Strosberg, Bouaouina, Ben Ahmed, Helal, Chouchane: Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. in BMC cancer 2006 (PubMed)

  7. Human Polyclonal Leptin Receptor Primary Antibody for ELISA, WB - ABIN1533146 : Tartaglia, Dembski, Weng, Deng, Culpepper, Devos, Richards, Campfield, Clark, Deeds, Muir, Sanker, Moriarty, Moore, Smutko, Mays, Wool, Monroe, Tepper: Identification and expression cloning of a leptin receptor, OB-R. in Cell 1996 (PubMed)

  8. Human Polyclonal Leptin Receptor Primary Antibody for FACS, IF (p) - ABIN730303 : De Matteis, Grandoni, Scatà, Catizone, Reale, Crisà, Moioli: Evaluation of leptin receptor expression on buffalo leukocytes. in Veterinary immunology and immunopathology 2016 (PubMed)

More Antibodies against Leptin Receptor Interaction Partners

Human Leptin Receptor (LEPR) interaction partners

  1. leptin (show LEP Antibodies)-LepRb plays an important role in the pathogenesis and depression in gastric cancer

  2. In 2 unrelated girls with severe obesity, three novel LEPR mutations were detected. Longitudinal growth data show normal childhood growth, and in the older girl, a normal adult height despite hypogonadotropic hypogonadism and the lack of an obvious pubertal growth spurt (show BPIFA1 Antibodies).

  3. genetic variability in the LEPR gene is associated with idiopathic recurrent spontaneous abortion; more frequent LEPR genotype in patients - rs7516341 (nominal P=0.034, odds ratio [OR] 0.61, 95% confidence interval [CI] 0.38-0.97) and rs1137101 (nominal P=0.048, OR 1.66, 95% CI 1.00-2.80)

  4. our findings suggest that leptin (show LEP Antibodies) promoted the proliferation, migration and invasion of gallbladder cancer (GBC) cells by increasing OB-Rb expression through the SOCS3 (show SOCS3 Antibodies)/JAK2 (show JAK2 Antibodies)/p-STAT3 (show STAT3 Antibodies) signal pathway. Targeting the leptin (show LEP Antibodies)/OB-Rb axis could be an attractive therapeutic strategy for treatment of GBC.

  5. genetic association studies in population of children (ages 5-10 years) in Poland: Data suggest that SNPs in LEPR are associated with predisposition to weight loss while engaging in lifestyle modifications for treatment of pediatric obesity in the population studied; carriers of wild-type K665N and at least one minor Q223R allele indicate greatest likelihood of losing weight.

  6. The placental weight ratio exerted a positive effect on the placental mRNA expression of insulin- like growth factor-I (show IGF1 Antibodies) and the long isoform of the leptin receptor in malaria-infected pregnant women without fever or chill symptoms.

  7. Data showed that TNF-a and IL-6 polymorphisms were associated with overall and site-specific osteoporosis in both sexes, and that these associations were dependent on rs1805096 and rs1892534 genotypes of LEPR.

  8. Genetic alterations in the leptin, LEPR and MC$R genes are associated with severe obesity.

  9. Effects of leptin (show LEP Antibodies) and leptin receptor SNPs on clinical- and metabolic-related traits in apparent treatment-resistant hypertension.

  10. this study shows the role of LEPR polymorphisms in the risk of multiple sclerosis and its severity in Iran

Mouse (Murine) Leptin Receptor (LEPR) interaction partners

  1. Leptin receptor expressing neurons express phosphodiesterase-3B (show PDE3B Antibodies) (PDE3B (show PDE3B Antibodies)) and leptin (show LEP Antibodies) induces STAT3 (show STAT3 Antibodies) activation in PDE3B (show PDE3B Antibodies) neurons in the mouse hypothalamus.

  2. JAK-STAT and hormone biosynthesis pathways were involved in the follicular development and ovulation disorders caused by LepR deficiency in ovaries

  3. Global loss of the leptin receptor results in reduced viral clearance and worse outcomes following influenza A infection.

  4. Human and murine pancreatic cancer cell lines were found to express the short as well as the long form of the leptin receptor and functionally responded to leptin (show LEP Antibodies) induced activation through an increased phosphorylation of AKT473.

  5. leptin (show LEP Antibodies) of dermal white adipose tissue might regulate hair growth and, therefore, hair cycle progression via leptin receptor on the hair follicle epithelium

  6. absence of leptin receptor on thymic epithelial cells or T cells does not lead to the loss of thymic function, demonstrating the thymoprotective effect of leptin (show LEP Antibodies) is mediated by obesity suppression rather than signalling to the thymus.

  7. High LEPR expression is associated with onset of obesity.

  8. The newly recognized effect of the leptin receptor Q223R mutation on diminished neutrophil chemotaxis and the impact of this mutation on multiple infectious diseases suggest a broader impact of this mutation on susceptibility to disease.

  9. data suggest that both adipose and placenta-derived leptin (show LEP Antibodies) system are involved in the regulation of energy metabolism during fetal growth.

  10. LepR(+) cells are the major source of bone and adipocytes in adult bone marrow

Pig (Porcine) Leptin Receptor (LEPR) interaction partners

  1. LEPR showed a lower variability than LEP (show LEP Antibodies) in the different analysed populations, especially in the Iberian breed that showed no variability

  2. Superactive human leptin (show LEP Antibodies) antagonist reverses leptin (show LEP Antibodies)-induced excessive progesterone and testosterone secretion in porcine ovarian follicles by blocking leptin (show LEP Antibodies) receptors.

  3. The presence of leptin and ObR-b varies across parities and is more intense in the uterus, ovaries and hypothalamus of females that were cycling before culling than in those having cystic ovaries.

  4. These results suggest that LEPR, MC4R, PIK3C3 and VRTN are useful markers for accurately predicting breeding values in Duroc pigs.

  5. Data showing changes in expression patterns of LEP/LEPR in endometrium/chorioallantoic membrane during placentation/fetal development suggest role for LEP/LEPR complex at early stages of pregnancy, possibly affecting the attachment process.

  6. Another funning discovery is ob-Rb mRNA in porcine endometrium was mainly negative-regulated by leptin (show LEP Antibodies)

  7. Leptin (show LEP Antibodies) and leptin receptor are expressed in porcine luteal cells, and there is a modulatory effect of LH, estradiol (E) and progesterone (P) on leptin (show LEP Antibodies) mRNA expression as well as E and P on leptin (show LEP Antibodies) secretion by those cells obtained in early pregnancy.

  8. These data suggest that leptin (show LEP Antibodies) might have a direct effect on porcine follicles and plays an important role in the follicular development.

  9. Locally produced leptin (show LEP Antibodies) plays a role in the regulation of porcine reproduction at the ovarian level and exerts a direct effect on follicles. Differences in long isoform of leptin receptor gene expression varies in the ovaries of pregnant and cyclic pigs.

  10. results suggest the T alleles of both LEP g.1387C>T and LEPR c.1987C>T, which are fixed in the Iberian pigs, would lead to an increase in growth, fatness and saturated fatty acid content in fat, which could be explained by an increased feed intake

Cow (Bovine) Leptin Receptor (LEPR) interaction partners

  1. Here, the association between DGAT1 (show DGAT1 Antibodies) K232A, SCD1 (show SCD Antibodies) A293V, and LEPR T945M markers with milk fat composition in southern Chile was evaluated. We genotyped the SNPs and calculated allele frequencies and Hardy-Weinberg equilibrium. The most frequent variants for DGAT1 (show DGAT1 Antibodies), SCD1 (show SCD Antibodies), and LEPR polymorphisms were GC/GC (show GC Antibodies), C, and C, respectively.

  2. I3 DNA copy number variations exhibited a significant negative correlation with LEPR gene expression

  3. The results suggest that a mutation of SCD1 (show SCD Antibodies), but not LEPR or ABCG2 (show ABCG2 Antibodies), might be useful as a DNA marker to decrease reproductive problems and improve production traits in Iranian Holstein dairy cows.

  4. SNP LEP significantly affected milk, protein and fat yield (P<0.05), and age at first calving (P<0.01) in analyzed population of cows. SNP LEPR/T945M affected significantly calving interval (P<0.01) only

  5. The use of leptin (show LEP Antibodies), leptin receptor, and DGAT1 (show DGAT1 Antibodies) polymorphisms as markers within genetic selection programs to improve and adjust several compositional parameters.

  6. The leptin (show LEP Antibodies) and receptor gene markers would be useful for marker-assisted selection.

  7. The leptin receptor SNP (T945M) was only weakly associated with milk per day and days to first service.

  8. The presence of the leptin receptor in bull spermatozoa was analyzed by RT-PCR and Southern hybridization and perhaps exerts physiologic effects.

  9. the possible involvement of locally produced leptin (show LEP Antibodies)/Ob-R system in the bovine ovary, suggesting roles in the function and/or development of the CL and growth of small follicles in an autocrine/paracrine fashion.

  10. findings indicate that acetate and butyrate enhance leptin (show LEP Antibodies) expression in bovine, but not in rat anterior pituitary cells while butyrate suppresses leptin receptor expression in both rat and bovine pituitaries

Rhesus Monkey Leptin Receptor (LEPR) interaction partners

  1. A 2-day fast increased leptin receptor (Ob-R) expression in the ventromedial nucleus (VMN).

Horse (Equine) Leptin Receptor (LEPR) interaction partners

  1. These results indicate that horse major salivary glands, like those of humans, are likely targets of leptin (show LEP Antibodies) actions, suggesting a functional role of leptin (show LEP Antibodies) on these glands.

Leptin Receptor (LEPR) Antigen Profile

Antigen Summary

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).

Alternative names and synonyms associated with Leptin Receptor (LEPR)

  • leptin receptor (lepr) antibody
  • leptin receptor (LEPR) antibody
  • leptin receptor (Lepr) antibody
  • leptin receptor overlapping transcript (Leprot) antibody
  • Leptin receptor-like (LOC100351924) antibody
  • leptin receptor-like (LOC100069504) antibody
  • CD295 antibody
  • db antibody
  • diabetes antibody
  • Fa antibody
  • LEP-R antibody
  • LEPR antibody
  • Leprb antibody
  • LEPRD antibody
  • LEPROT antibody
  • Modb1 antibody
  • Ob-R antibody
  • ob-rb antibody
  • OB-RGRP antibody
  • Ob-RM antibody
  • obese-like antibody
  • obl antibody
  • Obr antibody
  • ObRb antibody
  • Obrgrp antibody
  • VPS55 antibody

Protein level used designations for anti-Leptin Receptor (LEPR) Antibodies

OB receptor , huB219 , B219 , LEP-R , leptin receptor gene-related protein , OB-R , Leptin receptor (fatty) , cytokine receptor , leptin receptor long insert isoform , OB-R gene-related protein

724071 Xenopus (Silurana) tropicalis
3953 Homo sapiens
450207 Canis lupus familiaris
16847 Mus musculus
396836 Sus scrofa
497205 Bos taurus
24536 Rattus norvegicus
100725434 Cavia porcellus
374223 Gallus gallus
443264 Ovis aries
574126 Macaca mulatta
230514 Mus musculus
100351924 Oryctolagus cuniculus
100069504 Equus caballus
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