anti-Mouse (Murine) LIF antibody for Flow Cytometry

Recommended LIF Antibody (supplied by: Log in to see )

Antigen
Leukemia Inhibitory Factor (LIF) Antibodies
  • CDF
  • DIA
  • HILDA
  • MLPLI
  • A230075M04Rik
  • AW061234
  • LIF
  • leukemia inhibitory factor
  • leukemia inhibitory factor (cholinergic differentiation factor)
  • leukemia inhibitory factor receptor
  • Lif
  • LIF
  • Lifr
Reactivity
Human, Mouse (Murine)
148
84
31
11
7
6
5
2
2
2
1
1
Host
Rat
96
49
36
6
2
2
Clonality
Monoclonal
Conjugate
This LIF antibody is un-conjugated
7
6
6
6
6
5
5
4
3
3
3
3
3
3
3
3
3
3
2
2
1
1
Application
Flow Cytometry (FACS)
142
48
45
45
42
6
6
4
3
3
2
2
1
1
1
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Catalog No. ABIN2665228
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General

Antigen Leukemia Inhibitory Factor (LIF) Antibodies
Reactivity Human, Mouse (Murine)
(148), (84), (31), (11), (7), (6), (5), (2), (2), (2), (1), (1)
Host Rat
(96), (49), (36), (6), (2), (2)
Clonality (Clone)
Monoclonal   ( )
Conjugate This LIF antibody is un-conjugated
(7), (6), (6), (6), (6), (5), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (1), (1)
Application Flow Cytometry (FACS)
(142), (48), (45), (45), (42), (6), (6), (4), (3), (3), (2), (2), (1), (1), (1)
Pubmed 4 references available
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Product Details anti-LIF Antibody

Target Details LIF Application Details Handling References for anti-LIF antibody (ABIN2665228) Images
Purification The antibody was purified by affinity chromatography.
Clone M1506B09
Isotype IgG2a

Target Details LIF

Product Details anti-LIF Antibody Application Details Handling References for anti-LIF antibody (ABIN2665228) Images back to top
Antigen
Alternative Name LIF (LIF Antibody Abstract)
Background Leukemia inhibitory factor (LIF) is a pleiotropic cytokine that belongs to the IL-6 receptor family. It binds to a heterodimeric membrane receptor made up of a LIF-specific subunit, gp190, and the subunit gp130. The LIF complex receptor signals though STAT3 and JAK kinases. LIF expression has been observed in various tissues including the thymus, lung, and neuronal tissue. LIF displays diverse biological effects, but is best known for its ability to inhibit the differentiation of embryonic stem cells in mice and contributes to stem cell self-renewal. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, as well as the induction of neuronal cell differentiation. It also regulates mesenchymal to epithelial conversion during kidney development, and also may have a role in immune tolerance at the maternal-fetal interface. LIF can be upregulated by pro-inflammatory cytokines such as TNF-α and IL-17. Elevated levels of LIF have been found in cases of rheumatoid arthritis, neural injury, systemic inflammation, and tuberculosis.
Pathways JAK-STAT Signaling, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Stem Cell Maintenance, Growth Factor Binding

Application Details

Product Details anti-LIF Antibody Target Details LIF Handling References for anti-LIF antibody (ABIN2665228) Images back to top
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only

Handling

Product Details anti-LIF Antibody Target Details LIF Application Details References for anti-LIF antibody (ABIN2665228) Images back to top
Concentration 0.5 mg/mL
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment The antibody solution should be stored undiluted between 2°C and 8°C.

References for anti-LIF antibody (ABIN2665228)

Product Details anti-LIF Antibody Target Details LIF Application Details Handling Images back to top
Background publications

Metcalfe: "LIF in the regulation of T-cell fate and as a potential therapeutic." in: Genes and immunity, Vol. 12, Issue 3, pp. 157-68, 2011

Voyle, Haines, Pera, Forrest, Rathjen: "Human germ cell tumor cell lines express novel leukemia inhibitory factor transcripts encoding differentially localized proteins." in: Experimental cell research, Vol. 249, Issue 2, pp. 199-211, 1999

Tomida, Yamamoto-Yamaguchi, Hozumi: "Pregnancy associated increase in mRNA for soluble D-factor/LIF receptor in mouse liver." in: FEBS letters, Vol. 334, Issue 2, pp. 193-7, 1993

Moreau, Donaldson, Bennett, Witek-Giannotti, Clark, Wong: "Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells." in: Nature, Vol. 336, Issue 6200, pp. 690-2, 1989

Images

Product Details anti-LIF Antibody Target Details LIF Application Details Handling References for anti-LIF antibody (ABIN2665228) back to top
Supplier Images
Flow Cytometry (FACS) image for anti-Leukemia Inhibitory Factor (LIF) antibody (ABIN2665228) anti-Leukemia Inhibitory Factor (LIF) antibody
Western Blotting (WB) image for anti-Leukemia Inhibitory Factor (LIF) antibody (ABIN2665228) anti-Leukemia Inhibitory Factor (LIF) antibody (Image 2)