Browse our LIF Proteins (LIF)

Full name:
Leukemia Inhibitory Factor Proteins (LIF)
On are 88 Leukemia Inhibitory Factor (LIF) Proteins from 20 different suppliers available. Additionally we are shipping LIF Antibodies (152) and LIF Kits (80) and many more products for this protein. A total of 337 LIF products are currently listed.
A230075M04Rik, AW061234, CDF, DIA, HILDA, LIF, MLPLI
list all proteins Gene Name GeneID UniProt
LIF 16878 P09056
LIF 3976 P15018
LIF 60584  

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LIF Proteins (LIF) by Origin

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Top referenced LIF Proteins

  1. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2666883 : Souza, Palmqvist, Lundberg, Lundgren, Hänström, Souza, Conaway, Lerner: Interleukin-4 and interleukin-13 inhibit the expression of leukemia inhibitory factor and interleukin-11 in fibroblasts. in Molecular immunology 2012 (PubMed)
    Show all 6 references for 2666883

  2. Mouse (Murine) LIF Protein expressed in Escherichia coli (E. coli) - ABIN2666519 : Metcalfe: LIF in the regulation of T-cell fate and as a potential therapeutic. in Genes and immunity 2011 (PubMed)
    Show all 5 references for 2666519

  3. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN2018195 : Yu, Kastin, Pan: TNF reduces LIF endocytosis despite increasing NFkappaB-mediated gp130 expression. in Journal of cellular physiology 2007 (PubMed)
    Show all 2 references for 2018195

  4. Human LIF Protein expressed in Escherichia coli (E. coli) - ABIN667245 : Gillett, Lowe, Lu, Chan, Ferrara: Leukemia inhibitory factor expression in human carotid plaques: possible mechanism for inhibition of large vessel endothelial regrowth. in Growth factors (Chur, Switzerland) 1994 (PubMed)
    Show all 2 references for 667245

  5. Human LIF Protein expressed in Human Cells - ABIN2006356 : Salas, García-Barchino, Labiano, Shugay, Pérez-Encinas, Quinteiro, García-Delgado, Vizmanos, Novo: LIF, a Novel STAT5-Regulated Gene, Is Aberrantly Expressed in Myeloproliferative Neoplasms. in Genes & cancer 2011 (PubMed)

More Proteins for LIF Interaction Partners

Mouse (Murine) Leukemia Inhibitory Factor (LIF) interaction partners

  1. uterine expression of the LIFR (show LIFR Proteins) is essential for embryo implantation; this further define the components of the LIF signaling pathway necessary for effective implantation.

  2. LIF stimulates, in part, stem cell-derived cardiomyocyte regeneration by activating cardiac stem or precursor cells.

  3. Our data show that absence of SOCS2 (show SOCS2 Proteins) turns cardiomyocytes unresponsive to LIF-induced [Ca(2 (show CA2 Proteins)+)] raise, indicating that endogenous levels of SOCS2 (show SOCS2 Proteins) are crucial for full activation of LIF signaling in the heart.

  4. OSM (show OSM Proteins) (mOSM) signals mainly via an OSM (show OSM Proteins) receptor (OSMR (show OSMR Proteins))-gp130 (show LRPPRC Proteins) heterodimer and binds with only very low affinity to mLIFR.

  5. These results establish that Bcl3 (show BCL3 Proteins) positively regulates pluripotency genes and thus shed light on the mechanism of Bcl3 (show BCL3 Proteins) as a downstream molecule of LIF/STAT3 (show STAT3 Proteins) signaling in pluripotency maintenance.

  6. The role of LIF in acetylcholine synthesis via the STAT3 (show STAT3 Proteins), PI3 (show PI3 Proteins) kinases, or cAMP-protein kinase A pathways, are reported.

  7. Either LIF or EGF (show EGF Proteins) is needed during development of pre-implantation embryo.

  8. Our data suggest that LIF plays an important role in placentation in vivo and the maintenance of healthy pregnancy.

  9. Despite common signal transduction mechanisms (JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins), MAPK (show MAPK1 Proteins) and PI3K) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.

  10. Mechanistically, LIF activates STAT (show STAT1 Proteins), which binds to a Stat (show STAT1 Proteins) consensus sequence in the Six2 (show SIX2 Proteins) proximal promoter and sustains SIX2 (show SIX2 Proteins) levels.

Human Leukemia Inhibitory Factor (LIF) interaction partners

  1. Data suggest a 216-nucleotide proximal cis (show CISH Proteins)-element in LIF mRNA exhibits mRNA destabilizing potential; on exposure to carcinogen PMA (phorbol-12-myristate-13-acetate), this cis (show CISH Proteins)-element exhibits mRNA stabilizing activity. PMA induces nucleo-cytoplasmic translocation of both nucleolin (show NCL Proteins) and PCBP1 (show PCBP1 Proteins), 2 trans-acting factors that bind to and stabilize LIF mRNA. [LIF = leukemia inhibitory factor; PCBP1 (show PCBP1 Proteins) = poly(rC) binding protein 1 (show PCBP1 Proteins)]

  2. Leukemia inhibitory factor (LIF) - STAT3 (show STAT3 Proteins) transcription factor (STAT3 (show STAT3 Proteins)) signaling pathway is systemically dysregulated in in the endometrium of patients with recurrent/repeated implantation failure (RIFE).

  3. Endometrial expression of LIF and LIFR (show LIFR Proteins) is significantly reduced in the epithelial cells of infertile women.

  4. LIF SNP T/G (rs929271) seems to be a susceptibility biomarker capable of predicting implantation efficiency and pregnancy outcomes.

  5. Overexpression of LIF promotes Epithelial-mesenchymal transition and results in cancer.

  6. This review discusses the role of LIF and the recent analysis of its action on the uterine LE in regulating endometrial receptivity and implantation.

  7. Women with dormant genital tuberculosis were found to have decreased endometrial LIF-STAT3 (show STAT3 Proteins) signaling.

  8. Data show that leukemia inhibitory factor (LIF) signaling promote chemoresistance in cholangiocarcinoma by up-regulating myeloid cell factor-1 (Mcl-1 (show MCL1 Proteins)) via phosphatidylinositol 3-kinase (PI3K (show PIK3CA Proteins))/c-akt (show AKT1 Proteins) protein (AKT (show AKT1 Proteins))-dependent pathway.

  9. Despite common signal transduction mechanisms (JAK (show JAK3 Proteins)/STAT (show STAT1 Proteins), MAPK (show MAPK1 Proteins) and PI3K (show PIK3CA Proteins)) LIF can have paradoxically opposite effects in different cell types including stimulating or inhibiting each of cell proliferation, differentiation and survival.

  10. Taken together, we firstly demonstrate that LIF enhances the adhesion of trophoblastic cells to endometrial cells by up-regulating expression of integrin heterodimer alphaVbeta3 and alphaVbeta5.

Pig (Porcine) Leukemia Inhibitory Factor (LIF) interaction partners

  1. Cell cycle synchronization of leukemia inhibitory factor (LIF)-dependent porcine-induced pluripotent stem cells and the generation of cloned embryos.

  2. Studied effect of recombinant porcine leukemia inhibitory factor on in vitro maturation of porcine oocytes; p-STAT3 (show STAT3 Proteins) markedly increased in both cumulus cells and oocytes cultured in pLIF (show FTH1 Proteins)-supplemented media.

  3. LIF and IL-6 (show IL6 Proteins) are important components of embryo-uterine interactions during early pregnancy in the pig, and may contribute to successful conceptus implantation.

  4. Reprogramming pig fetal fibroblasts reveals a functional LIF signaling pathway.

  5. favorable effect on litter size in pigs of the A allele for a SNP within the LIF gene

  6. LIF (Leukemia inhibitory factor) mRNA was elevated in stented segments of coronary arteries; vascular smooth muscle cell proliferation was inhibited by LIF treatment in an in-vitro model of atherosclerosis

  7. study found significant association of two diallelic polymorphisms in the porcine genes for leukaemia inhibitory factor (LIF) and retinol-binding protein 4 (RBP4 (show RBP4 Proteins)) with number of piglets born alive (NBA) in two German pig lines

Cow (Bovine) Leukemia Inhibitory Factor (LIF) interaction partners

  1. Studied the effects of leukemia inhibitory factor (LIF) on bovine oocyte maturation and early embryo development in vitro.

  2. results suggest that leukemia inhibitory factor and macrophage-colony stimulating factor (show CSF2 Proteins) are produced in the endometrium and may play different roles in early and mid-pregnancy

LIF Protein Profile

Protein Summary

The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Alternative names and synonyms associated with LIF

  • leukemia inhibitory factor (Lif)
  • leukemia inhibitory factor (LIF)
  • leukemia inhibitory factor (cholinergic differentiation factor) (LIF)
  • leukemia inhibitory factor receptor (Lifr)
  • A230075M04Rik protein
  • AW061234 protein
  • CDF protein
  • DIA protein
  • HILDA protein
  • LIF protein
  • MLPLI protein

Protein level used designations for LIF

d factor , differentiation-stimulating factor , D factor , cholinergic differentiation factor , differentiation inhibitory activity , differentiation-inducing factor , hepatocyte-stimulating factor III , human interleukin in DA cells , melanoma-derived LPL inhibitor , leukemia inhibitory factor (cholinergic differentiation factor) , cholinergic neuronal differentiation factor , bLIF , leukemia inhibitory factor , D-factor/LIF receptor , LIF receptor , LIF-R , leukemia inhibitory factor receptor alpha chain , soluble differentiation-stimulating factor receptor

16878 Mus musculus
3976 Homo sapiens
427718 Gallus gallus
60584 Rattus norvegicus
399503 Sus scrofa
100713602 Cavia porcellus
101110180 Ovis aries
280840 Bos taurus
403449 Canis lupus familiaris
16880 Mus musculus
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