Browse our Oncostatin M Proteins (OSM)

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Oncostatin M Proteins (OSM)
On are 75 Oncostatin M (OSM) Proteins from 20 different suppliers available. Additionally we are shipping Oncostatin M Antibodies (208) and Oncostatin M Kits (63) and many more products for this protein. A total of 357 Oncostatin M products are currently listed.
OncoM, OSM
list all proteins Gene Name GeneID UniProt
OSM 5008 P13725
OSM 18413 P53347
OSM 289747 Q65Z15

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Oncostatin M Proteins (OSM) by Origin

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Top referenced Oncostatin M Proteins

  1. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN2666535 : Beigel, Friedrich, Probst, Sotlar, Göke, Diegelmann, Brand: Oncostatin M mediates STAT3-dependent intestinal epithelial restitution via increased cell proliferation, decreased apoptosis and upregulation of SERPIN family members. in PLoS ONE 2014 (PubMed)
    Show all 7 references for 2666535

  2. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN2667567 : Chen, Benveniste: Oncostatin M: a pleiotropic cytokine in the central nervous system. in Cytokine & growth factor reviews 2004 (PubMed)
    Show all 5 references for 2667567

  3. Human Oncostatin M Protein expressed in HEK-293 Cells - ABIN2181568 : Tanaka, Miyajima: Oncostatin M, a multifunctional cytokine. in Reviews of physiology, biochemistry and pharmacology 2003 (PubMed)
    Show all 3 references for 2181568

  4. Human Oncostatin M Protein expressed in HEK293 - ABIN2039658 : Yin, Chain: Suppression of lymphokine production in anti-minor histocompatibility antigen responses. in Cytokine 1991 (PubMed)
    Show all 3 references for 2039658

  5. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN413690 : Sen, Che, Rajamani, Zerboni, Sung, Ptacek, Arvin: Signal transducer and activator of transcription 3 (STAT3) and survivin induction by varicella-zoster virus promote replication and skin pathogenesis. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 references for 413690

  6. Human Oncostatin M Protein expressed in Escherichia coli (E. coli) - ABIN667495 : Nair, DeVico, Nakamura, Copeland, Chen, Patel, ONeil, Oroszlan, Gallo, Sarngadharan: Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. in Science (New York, N.Y.) 1992 (PubMed)
    Show all 2 references for 667495

More Proteins for Oncostatin M Interaction Partners

Human Oncostatin M (OSM) interaction partners

  1. OSM-induced plasticity was Signal Transducer and Activator of Transcription 3 (STAT3 (show STAT3 Proteins))-dependent, and also required a novel intersection with transforming growth factor-beta (TGF-beta)/SMAD (show SMAD1 Proteins) signaling. Removal of OSM or inhibition of STAT3 (show STAT3 Proteins) or SMAD3 (show SMAD3 Proteins) resulted in a marked reversion to a non-invasive, epithelial phenotype.

  2. Neutrophils are a major source of OSM-producing cells in patients with chronic rhinosinusitis and severe asthma.

  3. OSM and OSMR are highly expres (show TNF Proteins)sed in inflammatory bowel disease intestinal mucosa compared to control mucosa. OSM promotes inflammatory behavior in human intestinal stroma.

  4. Study showed that in atrial fibrillation (AF) with thrombus, the atrial tissue infiltration of M1 macrophages increased significantly; the OSM expression was also found to increase simultaneously; downstream tissue factor (show F3 Proteins) (TF) increased and tissue factor (show F3 Proteins) pathway inhibitors (TFPI (show TFPI Proteins))decreased, leading to an imbalance between TF and TFPI (show TFPI Proteins) eventually. OSM might be related to thrombosis in patients with AF mediated by TF and TFPI (show TFPI Proteins)

  5. a novel STAT3 (show STAT3 Proteins)/SMAD3 (show SMAD3 Proteins)-signaling axis is required for OSM-mediated senescence.

  6. This result demonstrates that HPV16 oncoproteins upregulate oncostatin M and play an important role to promote oral squamous cell carcinoma development

  7. The identification of the OSM inflammatory pathway as an important mediator of epithelial mesenchymal transition in triple-negative breast cancer (TNBC) may provide a novel potential opportunity to improve therapeutic strategies.

  8. Nucleolin stabilizes oncostatin-M mRNA by binding to a GC-rich element in its 3'UTR.

  9. Oncostatin M and interleukin-31 (show IL31 Proteins): Cytokines, receptors, signal transduction and physiology.

  10. Oncostatin M can regulate airway smooth muscle responses alone or in synergy with IL-17A (show IL17A Proteins).

Mouse (Murine) Oncostatin M (OSM) interaction partners

  1. OSM mitigated the proliferation of Th17 cells and decreased the expression of IL-17 (show IL17A Proteins) and IL-21 (show IL21 Proteins); it promoted the activation of suppressor of cytokine signaling 3 (SOCS3 (show SOCS3 Proteins)), STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins); observations suggest that OSM can inhibit Th17 differentiation by reciprocally controlling SOCS3 (show SOCS3 Proteins), STAT3 (show STAT3 Proteins), and STAT5 (show STAT5A Proteins)

  2. In an animal model of anti-TNF (show TNF Proteins)-resistant intestinal inflammation, genetic deletion or pharmacological blockade of OSM significantly attenuates colitis.

  3. these results support the proinflammatory role of OSM when it is overexpressed in the skin. However, OSM expression was not required in the murine model of psoriasis induced by topical application of imiquimod, as demonstrated by the inflammatory phenotype of OSM-deficient mice or wild-type mice treated with anti-OSM antibodies.

  4. OSM (mOSM) signals mainly via an OSM receptor (OSMR (show OSMR PLURAL_@42467@))-gp130 (show LRPPRC PLURAL_@42467@) heterodimer and binds with only very low affinity to mLIFR.

  5. Loss of Oncostatin M Signaling in Adipocytes Induces Insulin (show INS Proteins) Resistance and Adipose Tissue Inflammation in Vivo.

  6. mechanism of OSM-induced cardiomyocyte dedifferentiation is associated with B-Raf (show SNRPE Proteins)/Mek (show MDK Proteins)/Erk (show EPHB2 Proteins) signaling pathway through the OSM receptor Obeta

  7. Oncostatin M and interleukin-31 (show IL31 Proteins): Cytokines, receptors, signal transduction and physiology.

  8. OSM plays multiple critical roles in the maintenance and development of the hematopoietic microenvironment in the bone marrow at a steady state as well as after injury.

  9. OSM treatment preserved cardiac function, inhibited apoptosis and fibrosis, and stimulated angiogenesis via upregulating VEGF (show VEGFA Proteins) and bFGF (show FGF2 Proteins) in infarct border zone of ischemic myocardium, indicating that OSM could be a novel therapeutic target for MI.

  10. The mechanism of Oncostatin M on cardiac ischemia/reperfusion injury is partly mediated by the Notch3 (show NOTCH3 Proteins)/Akt (show AKT1 Proteins) pathway.

Cow (Bovine) Oncostatin M (OSM) interaction partners

  1. Protein kinase R plays a pivotal role in oncostatin M and interleukin-1 signalling in bovine articular cartilage chondrocytes.

Oncostatin M (OSM) Protein Profile

Protein Summary

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.

Alternative names and synonyms associated with Oncostatin M (OSM)

  • oncostatin M (OSM)
  • oncostatin M (Osm)
  • oncostatin M-like (LOC100342491)
  • oncostatin-M-like (LOC100152038)
  • OncoM protein
  • OSM protein

Protein level used designations for Oncostatin M Proteins (OSM)

oncostatin M , oncostatin-M

736338 Pan troglodytes
5008 Homo sapiens
18413 Mus musculus
289747 Rattus norvegicus
319086 Bos taurus
100724699 Cavia porcellus
611921 Canis lupus familiaris
101122466 Ovis aries
100342491 Oryctolagus cuniculus
100152038 Sus scrofa
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