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The Xenopus PIAS (show PIAS1 ELISA Kits) genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, high levels of PIAS2 in the notochord.
A direct interaction between Pold2 (show POLD2 ELISA Kits) and PIAS2 was confirmed by direct yeast two-hybrid.
Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1 (show GNB2L1 ELISA Kits).
regulates interleukin-7 receptor (show IL7R ELISA Kits) signaling at early commitment stages of B cell differentiation
a transcriptional cofactor for TFII-I (show GTF2I ELISA Kits)
Miz-1 (show ZBTB17 ELISA Kits) trans-actiates Nramp1 (show SLC11A1 ELISA Kits) in mice
Results show that Miz1 is required for early embryonic development during gastrulation.
Miz-1 has a role in inducing apoptosis along with MAGE-A4
study provides the first line of evidence that PIASxbeta is indispensable for osteoblast differentiation and matrix mineralization, and that this signaling molecule is located between Runx2 (show RUNX2 ELISA Kits) and osterix (show SP7 ELISA Kits).
strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1 (show ZBTB17 ELISA Kits)/BCL6 (show BCL6 ELISA Kits) and of Miz1 (show ZBTB17 ELISA Kits)/NAC1 (show NACC1 ELISA Kits) are reported
the expression of SENP8 (show SENP8 ELISA Kits), SAE1 (show SAE1 ELISA Kits), PIAS1 (show PIAS1 ELISA Kits), PIAS2 and ZMIZ1 (show ZMIZ1 ELISA Kits) is deregulated in the majority of PTC (show F9 ELISA Kits) tissues, likely contributing to the PTC (show F9 ELISA Kits) phenotype.
UXT (show UXT ELISA Kits) is a binding protein of PIAS2, and interaction between PIAS2 and UXT (show UXT ELISA Kits) may be important for the transcriptional activation of AR.
PIASxalpha is a novel SUMO E3 ligase for PTEN, and it positively regulates PTEN protein level in tumor suppression.
These findings suggest that SUMO-1 (show SUMO1 ELISA Kits) modification of MDA5 (show IFIH1 ELISA Kits) possibly via PIAS2beta may play a role in the MDA5 (show IFIH1 ELISA Kits)-mediated interferon (show IFNA ELISA Kits) response to viral infections.
PIASx may function as a co-repressor of Stat4 (show STAT4 ELISA Kits)
Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc (show MYC ELISA Kits), but not by 14-3-3eta and represses the expression of many genes
the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1 (show FLI1 ELISA Kits), identifying PIASxalpha as a novel corepressor of FLI-1 (show FLI1 ELISA Kits)
findings show that Epstein-Barr virus Rta (show RBM9 ELISA Kits) interacts and colocalizes with PIASxalpha and PIASxbeta in the nucleus; these interactions seem to enhance Rta (show RBM9 ELISA Kits) sumoylation
PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated.
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.
protein inhibitor of activated STAT, 2
, protein inhibitor of activated STAT X
, protein inhibitor of activated STAT2
, E3 SUMO-protein ligase PIAS2
, E3 SUMO-protein ligase PIAS2-like
, e3 SUMO-protein ligase PIAS2-like
, DAB2-interacting protein
, Msx-interacting-zinc finger
, androgen receptor-interacting protein 3
, msx-interacting zinc finger protein
, protein inhibitor of activated STAT x
, zinc finger, MIZ-type containing 4
, msx-interacting-zinc finger protein