Browse our PIAS2 Proteins (PIAS2)

On are 5 Protein Inhibitor of Activated STAT, 2 (PIAS2) Proteins from 3 different suppliers available. Additionally we are shipping PIAS2 Antibodies (126) and PIAS2 Kits (1) and many more products for this protein. A total of 156 PIAS2 products are currently listed.
6330408K17Rik, AI462206, ARIP3, AU018068, Dib, DIP, MGC83751, MIZ, MIZ1, PIAS2, PIASX, PIASX-ALPHA, PIASX-BETA, PIASxalpha, PIASxb, PIASxbeta, SIZ2, wu:fi05f09, ZMIZ4
list all proteins Gene Name GeneID UniProt
PIAS2 17344 Q8C5D8
PIAS2 9063 O75928
Rat PIAS2 PIAS2 83422 Q6AZ28

PIAS2 Proteins (PIAS2) by Origin

More Proteins for PIAS2 Interaction Partners

Xenopus laevis Protein Inhibitor of Activated STAT, 2 (PIAS2) interaction partners

  1. The Xenopus PIAS (show PIAS1 Proteins) genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, high levels of PIAS2 in the notochord.

Mouse (Murine) Protein Inhibitor of Activated STAT, 2 (PIAS2) interaction partners

  1. A direct interaction between Pold2 (show POLD2 Proteins) and PIAS2 was confirmed by direct yeast two-hybrid.

  2. Interaction of protein inhibitor of activated STAT 2 (PIAS2) with receptor of activated C kinase 1, RACK1 (show GNB2L1 Proteins).

  3. regulates interleukin-7 receptor (show IL7R Proteins) signaling at early commitment stages of B cell differentiation

  4. a transcriptional cofactor for TFII-I (show GTF2I Proteins)

  5. Miz-1 (show ZBTB17 Proteins) trans-actiates Nramp1 (show SLC11A1 Proteins) in mice

  6. Results show that Miz1 is required for early embryonic development during gastrulation.

  7. Miz-1 (show ZBTB17 Proteins) has a role in inducing apoptosis along with MAGE-A4 (show MAGEA4 Proteins)

  8. study provides the first line of evidence that PIASxbeta is indispensable for osteoblast differentiation and matrix mineralization, and that this signaling molecule is located between Runx2 (show RUNX2 Proteins) and osterix (show SP7 Proteins).

Human Protein Inhibitor of Activated STAT, 2 (PIAS2) interaction partners

  1. strategy for the purification of tethered POZ domains that form forced heterodimers is described, and crystal structures of the heterodimeric POZ domains of Miz1 (show ZBTB17 Proteins)/BCL6 (show BCL6 Proteins) and of Miz1 (show ZBTB17 Proteins)/NAC1 (show NACC1 Proteins) are reported

  2. the expression of SENP8 (show SENP8 Proteins), SAE1 (show SAE1 Proteins), PIAS1 (show PIAS1 Proteins), PIAS2 and ZMIZ1 is deregulated in the majority of PTC (show F9 Proteins) tissues, likely contributing to the PTC (show F9 Proteins) phenotype.

  3. UXT (show UXT Proteins) is a binding protein of PIAS2, and interaction between PIAS2 and UXT (show UXT Proteins) may be important for the transcriptional activation of AR.

  4. PIASxalpha is a novel SUMO E3 ligase for PTEN, and it positively regulates PTEN protein level in tumor suppression.

  5. These findings suggest that SUMO-1 (show SUMO1 Proteins) modification of MDA5 (show IFIH1 Proteins) possibly via PIAS2beta may play a role in the MDA5 (show IFIH1 Proteins)-mediated interferon (show IFNA Proteins) response to viral infections.

  6. PIASx may function as a co-repressor of Stat4 (show STAT4 Proteins)

  7. Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc (show MYC Proteins), but not by 14-3-3eta and represses the expression of many genes

  8. the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1 (show FLI1 Proteins), identifying PIASxalpha as a novel corepressor of FLI-1 (show FLI1 Proteins)

  9. findings show that Epstein-Barr virus Rta (show RBM9 Proteins) interacts and colocalizes with PIASxalpha and PIASxbeta in the nucleus; these interactions seem to enhance Rta (show RBM9 Proteins) sumoylation

  10. PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated.

PIAS2 Protein Profile

Protein Summary

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Isoforms of the encoded protein enhance the sumoylation of specific target proteins including the p53 tumor suppressor protein, c-Jun, and the androgen receptor. A pseudogene of this gene is located on the short arm of chromosome 4. The symbol MIZ1 has also been associated with ZBTB17 which is a different gene located on chromosome 1.

Alternative names and synonyms associated with PIAS2

  • protein inhibitor of activated STAT, 2 (pias2)
  • protein inhibitor of activated STAT, 2 (PIAS2)
  • protein inhibitor of activated STAT 2 (Pias2)
  • protein inhibitor of activated STAT, 2 (Pias2)
  • 6330408K17Rik protein
  • AI462206 protein
  • ARIP3 protein
  • AU018068 protein
  • Dib protein
  • DIP protein
  • MGC83751 protein
  • MIZ protein
  • MIZ1 protein
  • PIAS2 protein
  • PIASX protein
  • PIASX-ALPHA protein
  • PIASX-BETA protein
  • PIASxalpha protein
  • PIASxb protein
  • PIASxbeta protein
  • SIZ2 protein
  • wu:fi05f09 protein
  • ZMIZ4 protein

Protein level used designations for PIAS2

protein inhibitor of activated STAT, 2 , protein inhibitor of activated STAT X , protein inhibitor of activated STAT2 , E3 SUMO-protein ligase PIAS2 , E3 SUMO-protein ligase PIAS2-like , e3 SUMO-protein ligase PIAS2-like , DAB2-interacting protein , DIP , Msx-interacting-zinc finger , PIASxalpha6 , androgen receptor-interacting protein 3 , msx-interacting zinc finger protein , protein inhibitor of activated STAT x , zinc finger, MIZ-type containing 4 , ARIP3 , msx-interacting-zinc finger protein

432031 Xenopus laevis
455403 Pan troglodytes
564149 Danio rerio
696737 Macaca mulatta
100018269 Monodelphis domestica
100068879 Equus caballus
100073430 Ornithorhynchus anatinus
100391152 Callithrix jacchus
100466154 Ailuropoda melanoleuca
100584273 Nomascus leucogenys
100627995 Sus scrofa
17344 Mus musculus
9063 Homo sapiens
416383 Gallus gallus
480147 Canis lupus familiaris
83422 Rattus norvegicus
533403 Bos taurus
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