Browse our PIAS3 Proteins (PIAS3)

On are 6 Protein Inhibitor of Activated STAT, 3 (PIAS3) Proteins from 4 different suppliers available. Additionally we are shipping PIAS3 Antibodies (66) and PIAS3 Kits (14) and many more products for this protein. A total of 95 PIAS3 products are currently listed.
PIAS3, Pias3l, ZMIZ5
list all proteins Gene Name GeneID UniProt
PIAS3 229615 O54714
PIAS3 10401 Q9Y6X2
PIAS3 83614 O70260

PIAS3 Proteins (PIAS3) by Origin

More Proteins for PIAS3 Interaction Partners

Rhesus Monkey Protein Inhibitor of Activated STAT, 3 (PIAS3) interaction partners

  1. Suppressed Th17 levels correlated with upregulated expression of negative regulatory genes, PIAS3, SHP2, and SOCS3 in CD4 T cells during acute SIV infection.

Mouse (Murine) Protein Inhibitor of Activated STAT, 3 (PIAS3) interaction partners

  1. Data indicate that PIAS3 (protein inhibitor of activated STAT3) interaction modulates EKLF (erythroid Kruppel-like factor (show KLF1 Proteins)) activity in a promoter-dependent and SUMO-independent manner.

  2. PIAS3 suppresses acute graft-versus-host disease by modulating effector T and B cell subsets through inhibition of STAT3 (show STAT3 Proteins) activation.

  3. These data indicate that tachypacing decreased ATBF1, leading to enhanced STAT3 (show STAT3 Proteins) DNA-binding activity due to the reduced formation of a binary complex of ATBF1 and PIAS3.

  4. MRL/lpr (show FAS Proteins) mice have significantly increased expressions of STAT3 (show STAT3 Proteins) mRNA and protein and decreased expression of mRNA PIAS3 in the kidneys compared with BALB/C mice.

  5. L97A, R99N and R99Q mutations of the PINIT domain (PIAS3(85-272) ) were found to abrogate binding to STAT3 (show STAT3 Proteins), suggesting that these residues were part of a potential binding surface.

  6. Our results indicate that Pias3-dependent SUMOylation of photoreceptor-specific transcription factors is a common mechanism that controls both rod and cone photoreceptor subtype specification, regulating distinct molecular targets in the two cell types

  7. there is an interaction between Zimp7 and PIAS (show PIAS1 Proteins) proteins with higher preference for PIAS3, in androgen receptor (show AR Proteins)-mediated transcription

  8. results indicate a potential role of PIAS3 as transcriptional modulator of TIF2 (show NCOA2 Proteins)-mediated signalling

  9. role in inducing SUMO-1 (show SUMO1 Proteins) modification and transcriptional repression of IRF-1 (show IRF1 Proteins)

  10. identified a novel conserved domain of 180 residues in PIAS (show PIAS1 Proteins) proteins and showed that its 'PINIT' motif as well as other conserved motifs (in the SAP (show APCS Proteins) box and in the RING domain) are independently involved in nuclear retention of PIAS3L

Human Protein Inhibitor of Activated STAT, 3 (PIAS3) interaction partners

  1. SHP2 (show PTPN11 Proteins), SOCS3 (show SOCS3 Proteins) and PIAS3 levels are reduced in medulloblastomas in vivo and in vitro, of which PIAS3 downregulation is more reversely correlated with STAT3 (show STAT3 Proteins) activation. In resveratrol-suppressed medulloblastoma cells with STAT3 (show STAT3 Proteins) downregulation and decreased incidence of STAT3 (show STAT3 Proteins) nuclear translocation, PIAS3 is upregulated, the SHP2 (show PTPN11 Proteins) level remains unchanged and SOCS3 (show SOCS3 Proteins) is downregulated.

  2. The results revealed that although the expression levels of SOCS1 (show SOCS1 Proteins), SOCS3 (show SOCS3 Proteins) and, in particular, pSHP2, tend to decrease in the four types of astrocytomas, PIAS3 downregulation is more negatively correlated with STAT3 (show STAT3 Proteins) activation in the stepwise progress of astrocytomas and would indicate an unfavorable outcome.

  3. 3-Formylchromone inhibits proliferation and induces apoptosis of multiple myeloma cells by abrogating STAT3 (show STAT3 Proteins) signaling through the induction of PIAS3.

  4. PIAS3 may serve as a biomarker for predicting hormone therapy stratification, although it is limited to those breast cancer patients receiving hormone therapy.

  5. Taken together, these results suggest that PIAS3 functions as a positive regulator of HIF-1alpha (show HIF1A Proteins)-mediated transcription by increasing its protein stability.

  6. PIAS3 suppression may be protective against joint destruction in rheumatoid arthritis by regulating synoviocyte migration, invasion, and activation.

  7. PIAS3 primes ATR for checkpoint activation.

  8. PIAS3 expression in squamous cell lung cancer is low and predicts overall survival

  9. Adenovirus E4-ORF3 targets PIAS3 and together with E1B (show BCKDHB Proteins)-55K remodels SUMO2/SUMO3 Interactions in the nucleus and at virus genome replication domains.

  10. Statistically significant positive correlation has been found between STAT5B (show STAT5B Proteins) and COX-2, and significant negative correlation between STAT5B (show STAT5B Proteins) and PIAS3.

PIAS3 Protein Profile

Protein Summary

This gene encodes a member of the PIAS

Alternative names and synonyms associated with PIAS3

  • protein inhibitor of activated STAT, 3 (PIAS3)
  • protein inhibitor of activated STAT, 3 (pias3)
  • protein inhibitor of activated STAT 3 (Pias3)
  • protein inhibitor of activated STAT, 3 (Pias3)
  • protein inhibitor of activated STAT, 3 (LOC100341019)
  • PIAS3 protein
  • Pias3l protein
  • ZMIZ5 protein

Protein level used designations for PIAS3

protein inhibitor of activated STAT, 3 , E3 SUMO-protein ligase PIAS3-like , e3 SUMO-protein ligase PIAS3-like , E3 SUMO-protein ligase PIAS3 , protein inhibitor of activated STAT protein 3 , zinc finger, MIZ-type containing 5 , KChAP , potassium channel regulatory protein KChAP , potassium channel-associated protein

457223 Pan troglodytes
706775 Macaca mulatta
100144644 Xenopus (Silurana) tropicalis
100401461 Callithrix jacchus
100461795 Pongo abelii
100483204 Ailuropoda melanoleuca
229615 Mus musculus
10401 Homo sapiens
83614 Rattus norvegicus
444507 Xenopus laevis
483160 Canis lupus familiaris
535312 Bos taurus
100511878 Sus scrofa
100341019 Oryctolagus cuniculus
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