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Browse our anti-PIAS4 (PIAS4) Antibodies

Full name:
anti-Protein Inhibitor of Activated STAT, 4 Antibodies (PIAS4)
On are 102 Protein Inhibitor of Activated STAT, 4 (PIAS4) Antibodies from 23 different suppliers available. Additionally we are shipping PIAS4 Proteins (4) and PIAS4 Kits (2) and many more products for this protein. A total of 115 PIAS4 products are currently listed.
LOC100219439, Pias-gamma, pias4, Piasg, PIASY, wu:fc54c11, wu:fi18c10, wu:fi20e09, wu:fk93f11, zgc:66410, ZMIZ6
list all antibodies Gene Name GeneID UniProt
PIAS4 59004 Q9JM05
PIAS4 51588 Q8N2W9
PIAS4 362827  

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anti-Mouse (Murine) PIAS4 Antibodies:

anti-Human PIAS4 Antibodies:

anti-Rat (Rattus) PIAS4 Antibodies:

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Top referenced anti-PIAS4 Antibodies

  1. Human Polyclonal PIAS4 Primary Antibody for ICC, IF - ABIN269501 : Tong, Shen, Wang, Kan, Wang, Li, Wang, Yang, Guo: DNA ploidy cytometry testing for cervical cancer screening in China (DNACIC Trial): a prospective randomized, controlled trial. in Clinical cancer research : an official journal of the American Association for Cancer Research 2009 (PubMed)
    Show all 6 references for ABIN269501

  2. Human Polyclonal PIAS4 Primary Antibody for IHC (p), WB - ABIN388061 : Imoto, Sugiyama, Muromoto, Sato, Yamamoto, Matsuda: Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3. in The Journal of biological chemistry 2003 (PubMed)
    Show all 5 references for ABIN388061

  3. Cow (Bovine) Polyclonal PIAS4 Primary Antibody for WB - ABIN2777708 : Zhang, Xu, Han, Wei, Shu: PIASy represses TRIF-induced ISRE and NF-kappaB activation but not apoptosis. in FEBS letters 2004 (PubMed)
    Show all 2 references for ABIN2777708

  4. Human Polyclonal PIAS4 Primary Antibody for EIA, IHC (p) - ABIN356771 : Chun, Itoh, Subramanian, Iñiguez-Lluhí, Nakao: Modification of GATA-2 transcriptional activity in endothelial cells by the SUMO E3 ligase PIASy. in Circulation research 2003 (PubMed)
    Show all 2 references for ABIN356771

  5. Human Polyclonal PIAS4 Primary Antibody for ICC, IF - ABIN441248 : Alshareeda, Negm, Green, Nolan, Tighe, Albarakati, Sultana, Madhusudan, Ellis, Rakha: SUMOylation proteins in breast cancer. in Breast cancer research and treatment 2014 (PubMed)

  6. Human Polyclonal PIAS4 Primary Antibody for EIA, WB - ABIN783598 : Shuai, Liu: Regulation of gene-activation pathways by PIAS proteins in the immune system. in Nature reviews. Immunology 2005 (PubMed)

  7. Human Polyclonal PIAS4 Primary Antibody for EIA, IHC (p) - ABIN356770 : Albor, El-Hizawi, Horn, Laederich, Frosk, Wrogemann, Kulesz-Martin et al.: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ... in The Journal of biological chemistry 2006 (PubMed)

More Antibodies against PIAS4 Interaction Partners

Mouse (Murine) Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. PKA-induced SREBP1c (show SREBF1 Antibodies) sumoylation by PIASy.

  2. the SUMO E3 ligase (show PIAS1 Antibodies) PIASy (also known as PIAS4) was induced by hypoxia and prevented Sp1 (show SP1 Antibodies) from binding to the SIRT1 (show SIRT1 Antibodies) promoter.

  3. Piasy represses the synergistic activation of PITX2 (show PITX2 Antibodies) with interacting co-factors and Piasy represses Pias1 (show PIAS1 Antibodies) activation of PITX2 (show PITX2 Antibodies) transcriptional activity.

  4. Protein inhibitor of activated STAT (show STAT1 Antibodies), PIASy regulates alpha-smooth muscle actin (show ACTG2 Antibodies) expression by interacting with E12 (show ELSPBP1 Antibodies) in mesangial cells.

  5. PIASy negatively regulates both IFN transcription and IFN-stimulated gene expression through multiple mechanisms utilizing the function of different domains.

  6. Studies define an important role of PIASy in hypoxia signaling through promoting HIF1alpha (show HIF1A Antibodies) SUMOylation.

  7. PIASgamma as a transcriptional co-regulator of Nurr1 (show NR4A2 Antibodies) and suggest that this interaction may have a physiological role in regulating the expression of Nurr1 (show NR4A2 Antibodies) target genes.

  8. Piasy(-/-) mice appear phenotypically normal, activation of STAT1 (show STAT1 Antibodies) is not significantly perturbed, and sumoylation patterns for SUMO-1 (show SUMO1 Antibodies) or SUMO-3 (show SUMO3 Antibodies) modification are similar in wild-type and knockout mice

  9. Analysis of mice carrying a targeted mutation of the Piasy gene indicates that PIASy has a modest effect on cytokine and Wnt (show WNT2 Antibodies) signaling, suggesting its redundancy with other members of the PIAS (show PIAS1 Antibodies) family.

  10. analysis of gene regulatory interplay between TBP (show TBP Antibodies), PIAS1 (show PIAS1 Antibodies), PIAS3 (show PIAS3 Antibodies), PIASx, PIASy, ZFP523 (show ZNF76 Antibodies), and transcription factors

Human Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. these findings provide evidence for the effects of PIAsxalpha (show PIAS2 Antibodies) and its mechanism on osteosarcoma progression, which offers novel insight into sumoylation and the cell cycle in osteosarcoma.

  2. PIAS4 was identified as a candidate gene for abnormal head size in 13 patients with proximal 19p13.3 submicroscopic rearrangements .

  3. Our data reveal a novel and dynamic role for PIAS4 in the cellular-mediated restriction of herpesviruses and establish a new functional role for the PIAS family of SUMO ligases in the intrinsic antiviral immune response to DNA virus infection.

  4. PIAS4 activity are required for the AMPKalpha1 (show PRKAA1 Antibodies) SUMOylation and the inhibition of AMPKalpha1 (show PRKAA1 Antibodies) activity towards mTORC1 signalling.

  5. PIAS4 (rs735842) and VEGFA (show VEGFA Antibodies) (rs699947) were the most statistically significant variants associated in hypoxia pathway analysis.

  6. PIASgamma-dependent modification of tomosyn-1 (show STXBP5 Antibodies) with SUMO-2 (show SUMO2 Antibodies)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  7. SUMOylation of RXRalpha (show RXRA Antibodies) is significantly enhanced through PIAS4-mediated activity.

  8. High reactive oxygen speciesinduces oxidation and ubiquitin-mediated degradation of PIASgamma, thereby disrupting PIASgamma-IKKgamma (show IKBKG Antibodies) cross talk.

  9. Human melanoma patient samples and cell lines maintain p53 (show TP53 Antibodies) expression but PIASy and/or Tip60 (show KAT5 Antibodies) are frequently lost.

  10. PIAS4 was overexpressed in pancreatic cancer cells compared with normal pancreas; it interacts with the tumour suppressor von Hippel-Lindau (VHL) and leads to VHL (show VHL Antibodies) sumoylation, oligomerization and impaired function; study elucidates role of PIAS4 in regulation of pancreatic cancer cell growth

Xenopus laevis Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. Data suggest that PIASy exhibits a SIM (show SIM2 Antibodies) (SUMO-interacting motif) in addition to the SIM (show SIM2 Antibodies) identified in homologous proteins in other species; both SIMs are located near C terminus of PIASy, and both are required for full ligase activity of PIASy; hydrophobic core residues of the new SIM (show SIM2 Antibodies) are essential in binding to SUMO-3 (show SUMO3 Antibodies). (PIASy = protein inhibitors of activated STAT (show STAT1 Antibodies) y; SUMO-3 (show SUMO3 Antibodies) = small ubiquitin-like modifier 3 (show SUMO3 Antibodies))

  2. The Xenopus PIAS (show PIAS1 Antibodies) genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, strong expression of PIAS4 in the neural and neural crest derivatives.

  3. XPIASy functions as an essential negative regulator of the XSmad2 (show SMAD2 Antibodies) pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

  4. Data show that the Rod/Zw10 (show ZW10 Antibodies) complex interacts with the first 47 residues of PIASy which are important for mitotic SUMOylation, and that depletion of Rod compromises the centromeric localization of PIASy and SUMO2 (show SUMO2 Antibodies)/3 in mitosis.

Zebrafish Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. a PIAS4 homologue (zfPIAS4a) from the zebrafish model that shares many conserved structural hallmarks with the human and mammal PIAS4 proteins was successfully identified

PIAS4 Antigen Profile

Antigen Summary

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Alternative names and synonyms associated with PIAS4

  • protein inhibitor of activated STAT, 4 (PIAS4) antibody
  • protein inhibitor of activated STAT, 4 (pias4) antibody
  • protein inhibitor of activated STAT, 4 (LOC100219439) antibody
  • protein inhibitor of activated STAT 4 (Pias4) antibody
  • protein inhibitor of activated STAT, 4 (Pias4) antibody
  • protein inhibitor of activated STAT, 4a (pias4a) antibody
  • LOC100219439 antibody
  • Pias-gamma antibody
  • pias4 antibody
  • Piasg antibody
  • PIASY antibody
  • wu:fc54c11 antibody
  • wu:fi18c10 antibody
  • wu:fi20e09 antibody
  • wu:fk93f11 antibody
  • zgc:66410 antibody
  • ZMIZ6 antibody

Protein level used designations for PIAS4

protein inhibitor of activated STAT, 4 , protein inhibitor of activated STAT protein 4 , E3 SUMO-protein ligase PIAS4-like , e3 SUMO-protein ligase PIAS4-like , E3 SUMO-protein ligase PIAS4 , protein inhibitor of activated STAT PIASy , protein inhibitor of activated STAT protein gamma , PIAS-gamma , protein inhibitor of activated STAT protein PIASy , zinc finger, MIZ-type containing 6 , protein inhibitor of activated STAT 4

420095 Gallus gallus
496945 Xenopus (Silurana) tropicalis
736762 Pan troglodytes
100061365 Equus caballus
100219439 Taeniopygia guttata
100393272 Callithrix jacchus
100440650 Pongo abelii
100483638 Ailuropoda melanoleuca
100550652 Meleagris gallopavo
100624971 Sus scrofa
59004 Mus musculus
51588 Homo sapiens
494663 Xenopus laevis
485049 Canis lupus familiaris
534722 Bos taurus
362827 Rattus norvegicus
406712 Danio rerio
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