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Browse our PIAS4 (PIAS4) ELISA Kits

Full name:
Protein Inhibitor of Activated STAT, 4 ELISA Kits (PIAS4)
On are 2 Protein Inhibitor of Activated STAT, 4 (PIAS4) ELISA Kits from 2 different suppliers available. Additionally we are shipping PIAS4 Antibodies (102) and PIAS4 Proteins (4) and many more products for this protein. A total of 115 PIAS4 products are currently listed.
LOC100219439, Pias-gamma, pias4, Piasg, PIASY, wu:fc54c11, wu:fi18c10, wu:fi20e09, wu:fk93f11, zgc:66410, ZMIZ6
list all ELISA KIts Gene Name GeneID UniProt
PIAS4 59004 Q9JM05
PIAS4 51588 Q8N2W9
Rat PIAS4 PIAS4 362827  

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PIAS4 (PIAS4) ELISA Kits by Reactivity

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More ELISA Kits for PIAS4 Interaction Partners

Mouse (Murine) Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. PKA-induced SREBP1c (show SREBF1 ELISA Kits) sumoylation by PIASy.

  2. the SUMO E3 ligase (show PIAS1 ELISA Kits) PIASy (also known as PIAS4) was induced by hypoxia and prevented Sp1 (show SP1 ELISA Kits) from binding to the SIRT1 (show SIRT1 ELISA Kits) promoter.

  3. Piasy represses the synergistic activation of PITX2 (show PITX2 ELISA Kits) with interacting co-factors and Piasy represses Pias1 (show PIAS1 ELISA Kits) activation of PITX2 (show PITX2 ELISA Kits) transcriptional activity.

  4. Protein inhibitor of activated STAT (show STAT1 ELISA Kits), PIASy regulates alpha-smooth muscle actin (show ACTG2 ELISA Kits) expression by interacting with E12 (show ELSPBP1 ELISA Kits) in mesangial cells.

  5. PIASy negatively regulates both IFN transcription and IFN-stimulated gene expression through multiple mechanisms utilizing the function of different domains.

  6. Studies define an important role of PIASy in hypoxia signaling through promoting HIF1alpha (show HIF1A ELISA Kits) SUMOylation.

  7. PIASgamma as a transcriptional co-regulator of Nurr1 (show NR4A2 ELISA Kits) and suggest that this interaction may have a physiological role in regulating the expression of Nurr1 (show NR4A2 ELISA Kits) target genes.

  8. Piasy(-/-) mice appear phenotypically normal, activation of STAT1 (show STAT1 ELISA Kits) is not significantly perturbed, and sumoylation patterns for SUMO-1 (show SUMO1 ELISA Kits) or SUMO-3 (show SUMO3 ELISA Kits) modification are similar in wild-type and knockout mice

  9. Analysis of mice carrying a targeted mutation of the Piasy gene indicates that PIASy has a modest effect on cytokine and Wnt (show WNT2 ELISA Kits) signaling, suggesting its redundancy with other members of the PIAS (show PIAS1 ELISA Kits) family.

  10. analysis of gene regulatory interplay between TBP (show TBP ELISA Kits), PIAS1 (show PIAS1 ELISA Kits), PIAS3 (show PIAS3 ELISA Kits), PIASx, PIASy, ZFP523 (show ZNF76 ELISA Kits), and transcription factors

Human Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. these findings provide evidence for the effects of PIAsxalpha (show PIAS2 ELISA Kits) and its mechanism on osteosarcoma progression, which offers novel insight into sumoylation and the cell cycle in osteosarcoma.

  2. PIAS4 was identified as a candidate gene for abnormal head size in 13 patients with proximal 19p13.3 submicroscopic rearrangements .

  3. Our data reveal a novel and dynamic role for PIAS4 in the cellular-mediated restriction of herpesviruses and establish a new functional role for the PIAS family of SUMO ligases in the intrinsic antiviral immune response to DNA virus infection.

  4. PIAS4 activity are required for the AMPKalpha1 (show PRKAA1 ELISA Kits) SUMOylation and the inhibition of AMPKalpha1 (show PRKAA1 ELISA Kits) activity towards mTORC1 signalling.

  5. PIAS4 (rs735842) and VEGFA (show VEGFA ELISA Kits) (rs699947) were the most statistically significant variants associated in hypoxia pathway analysis.

  6. PIASgamma-dependent modification of tomosyn-1 (show STXBP5 ELISA Kits) with SUMO-2 (show SUMO2 ELISA Kits)/3 presents a novel mechanism to adapt secretory strength to the dynamic synaptic environment.

  7. SUMOylation of RXRalpha (show RXRA ELISA Kits) is significantly enhanced through PIAS4-mediated activity.

  8. High reactive oxygen speciesinduces oxidation and ubiquitin-mediated degradation of PIASgamma, thereby disrupting PIASgamma-IKKgamma (show IKBKG ELISA Kits) cross talk.

  9. Human melanoma patient samples and cell lines maintain p53 (show TP53 ELISA Kits) expression but PIASy and/or Tip60 (show KAT5 ELISA Kits) are frequently lost.

  10. PIAS4 was overexpressed in pancreatic cancer cells compared with normal pancreas; it interacts with the tumour suppressor von Hippel-Lindau (VHL) and leads to VHL (show VHL ELISA Kits) sumoylation, oligomerization and impaired function; study elucidates role of PIAS4 in regulation of pancreatic cancer cell growth

Xenopus laevis Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. Data suggest that PIASy exhibits a SIM (show SIM2 ELISA Kits) (SUMO-interacting motif) in addition to the SIM (show SIM2 ELISA Kits) identified in homologous proteins in other species; both SIMs are located near C terminus of PIASy, and both are required for full ligase activity of PIASy; hydrophobic core residues of the new SIM (show SIM2 ELISA Kits) are essential in binding to SUMO-3 (show SUMO3 ELISA Kits). (PIASy = protein inhibitors of activated STAT (show STAT1 ELISA Kits) y; SUMO-3 (show SUMO3 ELISA Kits) = small ubiquitin-like modifier 3 (show SUMO3 ELISA Kits))

  2. The Xenopus PIAS (show PIAS1 ELISA Kits) genes are expressed throughout early development and have overlapping and distinct expression patterns, with, for example, strong expression of PIAS4 in the neural and neural crest derivatives.

  3. XPIASy functions as an essential negative regulator of the XSmad2 (show SMAD2 ELISA Kits) pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

  4. Data show that the Rod/Zw10 (show ZW10 ELISA Kits) complex interacts with the first 47 residues of PIASy which are important for mitotic SUMOylation, and that depletion of Rod compromises the centromeric localization of PIASy and SUMO2 (show SUMO2 ELISA Kits)/3 in mitosis.

Zebrafish Protein Inhibitor of Activated STAT, 4 (PIAS4) interaction partners

  1. a PIAS4 homologue (zfPIAS4a) from the zebrafish model that shares many conserved structural hallmarks with the human and mammal PIAS4 proteins was successfully identified

PIAS4 Antigen Profile

Antigen Summary

Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.

Alternative names and synonyms associated with PIAS4

  • protein inhibitor of activated STAT, 4 (PIAS4) Elisa Kit
  • protein inhibitor of activated STAT, 4 (pias4) Elisa Kit
  • protein inhibitor of activated STAT, 4 (LOC100219439) Elisa Kit
  • protein inhibitor of activated STAT 4 (Pias4) Elisa Kit
  • protein inhibitor of activated STAT, 4 (Pias4) Elisa Kit
  • protein inhibitor of activated STAT, 4a (pias4a) Elisa Kit
  • LOC100219439 Elisa Kit
  • Pias-gamma Elisa Kit
  • pias4 Elisa Kit
  • Piasg Elisa Kit
  • PIASY Elisa Kit
  • wu:fc54c11 Elisa Kit
  • wu:fi18c10 Elisa Kit
  • wu:fi20e09 Elisa Kit
  • wu:fk93f11 Elisa Kit
  • zgc:66410 Elisa Kit
  • ZMIZ6 Elisa Kit

Protein level used designations for PIAS4

protein inhibitor of activated STAT, 4 , protein inhibitor of activated STAT protein 4 , E3 SUMO-protein ligase PIAS4-like , e3 SUMO-protein ligase PIAS4-like , E3 SUMO-protein ligase PIAS4 , protein inhibitor of activated STAT PIASy , protein inhibitor of activated STAT protein gamma , PIAS-gamma , protein inhibitor of activated STAT protein PIASy , zinc finger, MIZ-type containing 6 , protein inhibitor of activated STAT 4

420095 Gallus gallus
496945 Xenopus (Silurana) tropicalis
736762 Pan troglodytes
100061365 Equus caballus
100219439 Taeniopygia guttata
100393272 Callithrix jacchus
100440650 Pongo abelii
100483638 Ailuropoda melanoleuca
100550652 Meleagris gallopavo
100624971 Sus scrofa
59004 Mus musculus
51588 Homo sapiens
494663 Xenopus laevis
485049 Canis lupus familiaris
534722 Bos taurus
362827 Rattus norvegicus
406712 Danio rerio
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