Browse our Prolactin Proteins (PRL)

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Prolactin Proteins (PRL)
On are 148 Prolactin (PRL) Proteins from 22 different suppliers available. Additionally we are shipping Prolactin Antibodies (529) and Prolactin Kits (140) and many more products for this protein. A total of 837 Prolactin products are currently listed.
AV290867, prl, Prl1a1, PRLB, PRLSD1, Prol, prolactin, RATPRLSD1, RNPROL
list all proteins Gene Name GeneID UniProt
PRL 5617 P01236
Rat PRL PRL 24683 P01237
Mouse PRL PRL 19109  

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Prolactin Proteins (PRL) by Origin

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Top referenced Prolactin Proteins

  1. Human Prolactin Protein expressed in Escherichia coli (E. coli) - ABIN2666567 : Ben-Jonathan, LaPensee, LaPensee: What can we learn from rodents about prolactin in humans? in Endocrine reviews 2008 (PubMed)
    Show all 7 references for 2666567

  2. Mouse (Murine) Prolactin Protein expressed in Baculovirus infected Insect Cells - ABIN2007718 : Tworoger, Hankinson: Prolactin and breast cancer risk. in Cancer letters 2006 (PubMed)

More Proteins for Prolactin Interaction Partners

Human Prolactin (PRL) interaction partners

  1. findings show that cysteine in the PRL catalytic site is endogenously phosphorylated as part of the catalytic cycle and that phosphocysteine levels change in response to Mg(2 (show MUC7 Proteins)+) levels.

  2. Depression and anxiety in subfertile males are associated with higher secretion of PRL.

  3. Prolactin rs1341239 T allele decreases the risk of brick tea fluorosis in the Inner Mongolia in China population.

  4. In breast cancer, PRL hormone and its signaling pathway may play an important role in maintaining tumor differentiation state and in turn better patient outcome.

  5. Data indicate 12 single nucleotide polymorphism (SNPs) associated with increased prolactin levels in both plasma and cerebrospinal fluid (CSF (show CSF2 Proteins)).

  6. these data strongly support a critical interplay between prolactin and estrogen via PAK1 (show PAK1 Proteins) and suggest that ligand-independent activation of ERalpha (show ESR1 Proteins) through prolactin/PAK1 (show PAK1 Proteins) may impart resistance to anti-estrogen therapies.

  7. These data provide insight into the mechanisms guiding PRL-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 (show PAK1 Proteins) in breast cancer metastasis.

  8. changes in mRNA expression of selected toll (show TLR4 Proteins)-like receptors (TLR2, TLR4 (show TLR4 Proteins), TLR7 (show TLR7 Proteins)), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12 (show IL12A Proteins), IL-10 (show IL10 Proteins)) in peripheral blood monocytes of celiac disease patients, were investiagted.

  9. The review focuses on the role of prolactin in breast development, bone homeostasis and in breast cancer to bone metastases. (Review)

  10. Study demonstrate that PRL is necessary for the survival of (retinal pigment epithelium) RPE (show RPE Proteins) under normal and advancing age conditions and, identified SIRT2 (show SIRT2 Proteins) and TRPM2 (show CLU Proteins) as molecular targets for the antioxidant and antiapoptotic actions of PRL in the RPE (show RPE Proteins).

Mouse (Murine) Prolactin (PRL) interaction partners

  1. Mechanistically, RL negatively regulates Stat5 (show STAT5A Proteins) phosphorylation and Elf5 (show ELF5 Proteins) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 (show STAT5A Proteins) pathway.

  2. Twenty-two separate mouse genes encode the placenta Prl-related hormones

  3. Prolactin transport into mouse brain is independent of prolactin receptor (show PRLR Proteins).

  4. Survivin (show BIRC5 Proteins) directly participates in PRL-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy

  5. the mechanism by which kisspeptin is suppressed during lactation involves a number of factors, including chronically elevated levels of prolactin

  6. Over 24 hours, males displayed no oscillation in PRL level; virgin and lactating females showed large pulses. Peaks reached 30-40 ng/mL in lactating mice and rarely exceeded 10 ng/mL in virgin mice. Pulses in lactating mice were associated with suckling.

  7. Prolactin induces apoptosis of lactotropes

  8. N-terminal PRL fragment increases during the involution period, has a proapoptotic effect on mammary epithelial cells, and is mainly generated by secreted cathepsin D (show CTSD Proteins) in the extracellular space of mammary glands.

  9. PRL constrains tumor-promoting liver inflammation.

  10. Prolactin levels correlate with abnormal B cell maturation (show TNFRSF17 Proteins) in MRL and MRL/lpr (show FAS Proteins) mouse models of systemic lupus erythematosus-like disease.

Cow (Bovine) Prolactin (PRL) interaction partners

  1. Taken together, these results support novel functions of prolactin as a modulator of the innate immune response that do not involve the classical prolactin pathway.

  2. The presence and localization of prolactin receptor (show PRLR Proteins) are consistent with expression data reported for other species, and the presence of PIP (show PIP Proteins) and prolactin in seminal fluid is consistent with data generated in humans.

  3. Functionally reciprocal mutations of the prolactin signaling pathway define hairy and slick cattle.

  4. The single nucleotide polymorphism rs42646708 of cattle XKR4 was significantly associated with serum prolactin concentrations and explained 2.45% of the phenotypic variation.

  5. Five mutations were identified in exonic region and eleven in associated intronic regions in PRL gene in 100 cattle from four Pakistani cattle breeds.

  6. this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL gene transcription in dairy cow anterior pituitary cells

  7. These data suggest that PRL protects brain endothelial cells against methamphetamine-induced toxicity

  8. Bovine prolactin improved the expression of human transferrin (show Tf Proteins) through such a possible mechanism that bovine prolactin activated STAT5a (show STAT5A Proteins) transcription expression.

  9. There was no significant difference between 1134 locus and milk performance traits of 5'-UTR of PRL gene

  10. Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.

Pig (Porcine) Prolactin (PRL) interaction partners

  1. Prolactin and, to a lesser extent progesterone, which increase in early pregnancy, enhance basal and glucose-stimulated insulin (show INS Proteins) secretion in part by increasing glucokinase (show GCK Proteins) activity and amplifying cAMP levels.

  2. iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction

  3. despite a lack of clear relationship between PRL/C499T polymorphism in 5' UTR of the PRL gene and plasma prolactin cioncentration, gene polymorphism impact on reproductiove performance cannot be excluded

Goat Prolactin (PRL) interaction partners

  1. diameter. These results imply that the PRL gene polymorphism can be used as a molecular marker to improve fiber production without a negative effect on fiber diameter.

Prolactin (PRL) Protein Profile

Protein Summary

This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein.

Alternative names and synonyms associated with Prolactin (PRL)

  • prolactin (PRL)
  • prolactin, gene 3 (prl.3)
  • prolactin (Prl)
  • prolactin (LOC100136792)
  • prolactin (LOC100136580)
  • prolactin-like (LOC101843376)
  • AV290867 protein
  • prl protein
  • Prl1a1 protein
  • PRLB protein
  • PRLSD1 protein
  • Prol protein
  • prolactin protein
  • RATPRLSD1 protein
  • RNPROL protein

Protein level used designations for Prolactin Proteins (PRL)

prolactin , prolactin, gene 3 , prolactin 2 , decidual prolactin , prolactin family 1, subfamily a, member 1 , preprolactin

100126745 Papio anubis
100310824 Xenopus laevis
5617 Homo sapiens
443317 Ovis aries
24683 Rattus norvegicus
19109 Mus musculus
280901 Bos taurus
488241 Canis lupus familiaris
751517 Felis catus
396453 Gallus gallus
100009394 Oryctolagus cuniculus
396965 Sus scrofa
100499538 Cavia porcellus
100034034 Equus caballus
707052 Macaca mulatta
100136792 Oncorhynchus mykiss
100136580 Salmo salar
100481524 Ailuropoda melanoleuca
100861193 Capra hircus
101843376 Mesocricetus auratus
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