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The production of PRL by Mvarphis was increased by unknown components of rheumatoid arthritis and rheumatoid arthritis synovial fluid, where it could contribute to disease progression.
findings show that cysteine in the PRL catalytic site is endogenously phosphorylated as part of the catalytic cycle and that phosphocysteine levels change in response to Mg(2 (show MUC7 Proteins)+) levels.
Depression and anxiety in subfertile males are associated with higher secretion of PRL.
Prolactin rs1341239 T allele decreases the risk of brick tea fluorosis in the Inner Mongolia in China population.
In breast cancer, PRL hormone and its signaling pathway may play an important role in maintaining tumor differentiation state and in turn better patient outcome.
Data indicate 12 single nucleotide polymorphism (SNPs) associated with increased prolactin levels in both plasma and cerebrospinal fluid (CSF (show CSF2 Proteins)).
these data strongly support a critical interplay between prolactin and estrogen via PAK1 (show PAK1 Proteins) and suggest that ligand-independent activation of ERalpha (show ESR1 Proteins) through prolactin/PAK1 (show PAK1 Proteins) may impart resistance to anti-estrogen therapies.
These data provide insight into the mechanisms guiding PRL-mediated breast cancer cell motility and invasion and highlight a significant role for phosphoTyr-PAK1 (show PAK1 Proteins) in breast cancer metastasis.
changes in mRNA expression of selected toll (show TLR4 Proteins)-like receptors (TLR2, TLR4 (show TLR4 Proteins), TLR7 (show TLR7 Proteins)), stress cytokine prolactin (PRL), and proand anti-inflammatory cytokines (TNF-alpha (show TNF Proteins), IL-6 (show IL6 Proteins), IL-12 (show IL12A Proteins), IL-10 (show IL10 Proteins)) in peripheral blood monocytes of celiac disease patients, were investiagted.
The review focuses on the role of prolactin in breast development, bone homeostasis and in breast cancer to bone metastases. (Review)
Mechanistically, RL negatively regulates Stat5 (show STAT5A Proteins) phosphorylation and Elf5 (show ELF5 Proteins) expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 (show STAT5A Proteins) pathway.
Twenty-two separate mouse genes encode the placenta Prl-related hormones
Prolactin transport into mouse brain is independent of prolactin receptor (show PRLR Proteins).
Survivin (show BIRC5 Proteins) directly participates in PRL-mediated beta cell proliferation via Akt (show AKT1 Proteins), STAT5 (show STAT5A Proteins)-PIM (show PIM1 Proteins) and ERK (show EPHB2 Proteins) signalling pathways during pregnancy
the mechanism by which kisspeptin is suppressed during lactation involves a number of factors, including chronically elevated levels of prolactin
Over 24 hours, males displayed no oscillation in PRL level; virgin and lactating females showed large pulses. Peaks reached 30-40 ng/mL in lactating mice and rarely exceeded 10 ng/mL in virgin mice. Pulses in lactating mice were associated with suckling.
Prolactin induces apoptosis of lactotropes
N-terminal PRL fragment increases during the involution period, has a proapoptotic effect on mammary epithelial cells, and is mainly generated by secreted cathepsin D (show CTSD Proteins) in the extracellular space of mammary glands.
PRL constrains tumor-promoting liver inflammation.
Prolactin levels correlate with abnormal B cell maturation (show TNFRSF17 Proteins) in MRL and MRL/lpr (show FAS Proteins) mouse models of systemic lupus erythematosus-like disease.
Taken together, these results support novel functions of prolactin as a modulator of the innate immune response that do not involve the classical prolactin pathway.
The presence and localization of prolactin receptor (show PRLR Proteins) are consistent with expression data reported for other species, and the presence of PIP (show PIP Proteins) and prolactin in seminal fluid is consistent with data generated in humans.
Functionally reciprocal mutations of the prolactin signaling pathway define hairy and slick cattle.
The single nucleotide polymorphism rs42646708 of cattle XKR4 was significantly associated with serum prolactin concentrations and explained 2.45% of the phenotypic variation.
Five mutations were identified in exonic region and eleven in associated intronic regions in PRL gene in 100 cattle from four Pakistani cattle breeds.
this study identifies a biochemical mechanism for the regulation of SCFAs on bovine GH and PRL gene transcription in dairy cow anterior pituitary cells
These data suggest that PRL protects brain endothelial cells against methamphetamine-induced toxicity
Bovine prolactin improved the expression of human transferrin (show Tf Proteins) through such a possible mechanism that bovine prolactin activated STAT5a (show STAT5A Proteins) transcription expression.
There was no significant difference between 1134 locus and milk performance traits of 5'-UTR of PRL gene
Staphylococcus aureus infection inhibits nuclear factor kappa B activation mediated by prolactin in bovine mammary epithelial cells.
Prolactin and, to a lesser extent progesterone, which increase in early pregnancy, enhance basal and glucose-stimulated insulin (show INS Proteins) secretion in part by increasing glucokinase (show GCK Proteins) activity and amplifying cAMP levels.
iv infusion of prolactin primarily caused coronary, mesenteric, renal, and iliac vasoconstriction
despite a lack of clear relationship between PRL/C499T polymorphism in 5' UTR of the PRL gene and plasma prolactin cioncentration, gene polymorphism impact on reproductiove performance cannot be excluded
diameter. These results imply that the PRL gene polymorphism can be used as a molecular marker to improve fiber production without a negative effect on fiber diameter.
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein.
, prolactin, gene 3
, prolactin 2
, decidual prolactin
, prolactin family 1, subfamily a, member 1